Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Pirjo M, Apaja"'
Autor:
Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2023)
Abstract Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft
Externí odkaz:
https://doaj.org/article/e79655148af34996b2fadab1d06fecb9
Autor:
Ben B. Wang, Pirjo M. Apaja
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 260-263 (2022)
Protein quality control (PQC) is a conformational surveillance system critical to maintaining native protein composition in the cell. However, PQC mechanisms at the endo-lysosomal pathway especially toward membrane proteins and during cumulative endo
Externí odkaz:
https://doaj.org/article/abb59309d3204875bf19f066c72e1121
Autor:
Haijin Xu, Sandra Isenmann, Tania López-Hernández, Raúl Estévez, Gergely L. Lukacs, Pirjo M. Apaja
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The significance of crosstalks among constituents of plasma membrane protein clusters/complexes in cellular proteostasis and protein quality control (PQC) remains incompletely understood. Examining the glial (enriched) cell adhesion molecule
Externí odkaz:
https://doaj.org/article/eca27c5cd8744f3faa3f91b5a2225771
Autor:
Jalal M. Kazan, Guillaume Desrochers, Claire E. Martin, Hyeonju Jeong, Dmitri Kharitidi, Pirjo M. Apaja, Ariel Roldan, Nicole St. Denis, Anne-Claude Gingras, Gergely L. Lukacs, Arnim Pause
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103274- (2021)
Summary: Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms compl
Externí odkaz:
https://doaj.org/article/f8eb2fe20c114718a6151e5c0fe42afc
Autor:
Miklos Bagdany, Guido Veit, Ryosuke Fukuda, Radu G. Avramescu, Tsukasa Okiyoneda, Imad Baaklini, Jay Singh, Guy Sovak, Haijin Xu, Pirjo M. Apaja, Sara Sattin, Lenore K. Beitel, Ariel Roldan, Giorgio Colombo, William Balch, Jason C. Young, Gergely L. Lukacs
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The F508 deletion (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common CF causing mutation. Here the authors show that cytosolic chaperones shift the F508del channel conformation to the native fold by kinetic
Externí odkaz:
https://doaj.org/article/e14a35b0276c400f88eedbb10dd40d9d
Autor:
Dmitri Kharitidi, Pirjo M. Apaja, Sanaz Manteghi, Kei Suzuki, Elena Malitskaya, Ariel Roldan, Marie-Claude Gingras, Junichi Takagi, Gergely L. Lukacs, Arnim Pause
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 599-609 (2015)
Membrane trafficking of integrins plays a pivotal role in cell proliferation and migration. How endocytosed integrins are targeted either for recycling or lysosomal delivery is not fully understood. Here, we show that fibronectin (FN) binding to α5
Externí odkaz:
https://doaj.org/article/1e10c0e967634d08996299c6e5f36acf
Autor:
Guido Veit, Kathryn Oliver, Pirjo M Apaja, Doranda Perdomo, Aurélien Bidaud-Meynard, Sheng-Ting Lin, Jingyu Guo, Mert Icyuz, Eric J Sorscher, John L Hartman, Gergely L Lukacs
Publikováno v:
PLoS Biology, Vol 14, Iss 5, p e1002462 (2016)
The most common cystic fibrosis (CF) causing mutation, deletion of phenylalanine 508 (ΔF508 or Phe508del), results in functional expression defect of the CF transmembrane conductance regulator (CFTR) at the apical plasma membrane (PM) of secretory e
Externí odkaz:
https://doaj.org/article/2e5a3f66228046208e973fd23ba3f520
Autor:
Ben B. Wang, Haijin Xu, Sandra Isenmann, Cheng Huang, Xabier Elorza-Vidal, Grigori Y. Rychkov, Raúl Estévez, Ralf B. Schittenhelm, Gergely L. Lukacs, Pirjo M. Apaja
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
The cellular defense mechanisms against cumulative endo-lysosomal stress remain incompletely understood. Here, we identify Ubr1 as a protein quality control (QC) E3 ubiquitin-ligase that counteracts proteostasis stresses by facilitating endosomal car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0814e52774cb5563ac1b10f508903b95
http://hdl.handle.net/2445/184542
http://hdl.handle.net/2445/184542
Autor:
Ben B, Wang, Haijin, Xu, Sandra, Isenmann, Cheng, Huang, Xabier, Elorza-Vidal, Grigori Y, Rychkov, Raúl, Estévez, Ralf B, Schittenhelm, Gergely L, Lukacs, Pirjo M, Apaja
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(3)
The cellular defense mechanisms against cumulative endo-lysosomal stress remain incompletely understood. Here, we identify Ubr1 as a protein quality control (QC) E3 ubiquitin-ligase that counteracts proteostasis stresses by facilitating endosomal car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b39c29a9195ce11b2219f8b9f50428f
https://pubmed.ncbi.nlm.nih.gov/35233680
https://pubmed.ncbi.nlm.nih.gov/35233680
Autor:
Sandra Isenmann, Ralf B. Schittenhelm, Pirjo M. Apaja, Ben B. Wang, Cheng Huang, Xabier Elorza-Vidal, Haijin Xu, Gergely L. Lukacs, Grigori Y. Rychkov, Raúl Estévez
The defence mechanisms against endo-lysosomal homeostasis stress remain incompletely understood. Here, we identify Ubr1 as a protein quality control (QC) ubiquitin ligase that counteracts proteostasis stress by enhancing cargo selective autophagy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efadcbd4435faa807b9946a8a5e51134
https://doi.org/10.1101/2021.10.05.463117
https://doi.org/10.1101/2021.10.05.463117