Výsledky vyhledávání - "Piret Michelson"

Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

Autor: Priit Kogerman, Alla Maloverjan, Torben Østerlund, Marko Piirsoo, Piret Michelson

Publikováno v: Experimental Cell Research. 316:627-637

The Hedgehog (Hh) signaling pathway plays crucial roles in embryonic development and is implicated in tissue homeostasis maintenance and neurogenesis in adults. Aberrant activation of Hh signaling is associated with various developmental abnormalitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13de499107975f0abc24f6fae8e78125
https://doi.org/10.1016/j.yexcr.2009.10.018

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Identification of the gene transcription repressor domain of Gli3

Autor: Piret Tiigimägi, Torben Østerlund, Piret Michelson, Robert Tsanev, Madis Metsis, Priit Kogerman

Publikováno v: Febs Letters

Gli transcription factors are downstream targets of the Hedgehog signaling pathway. Two of the three Gli proteins harbor gene transcription repressor function in the N-terminal half. We have analyzed the sequences and identified a potential repressor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2daf114e4bc1baaf9fcf0d5fa412e01
http://europepmc.org/articles/PMC2697317

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Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins

Autor: Piret Michelson, Priit Kogerman, Marina Dunaeva, Rune Toftgård

Publikováno v: Journal of Biological Chemistry. 278:5116-5122

The Hedgehog signaling pathway is involved in both development and cancer induction in a wide range of organisms. The end point of the Hedgehog signal-transduction cascade is the Gli/Ci, zinc-finger transcription factors. Proteins such as Fused, Supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75b87849c1ed983ecb3aca87fb73553
https://doi.org/10.1074/jbc.m209492200

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Missense mutations in the extracellular domain of the human neural cell adhesion molecule L1 reduce neurite outgrowth of murine cerebellar neurons

Autor: Piret Michelson, Christine Hartwig, Andres Veske, Melitta Schachner, Andreas Gal, Ulrich Finckh

Publikováno v: Human mutation. 20(6)

Mutations in L1CAM, the gene encoding the transmembrane multifunctional neuronal adhesion molecule L1, are associated with neurodevelopmental disorders including X-linked hydrocephalus and mental retardation. Some amino acid substitutions in various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e822422168b830b04c118b20c0386
https://pubmed.ncbi.nlm.nih.gov/12442287

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