Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Pires, Douglas"'
Autor:
Kenlay, Henry, Dreyer, Frédéric A., Kovaltsuk, Aleksandr, Miketa, Dom, Pires, Douglas, Deane, Charlotte M.
Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequ
Externí odkaz:
http://arxiv.org/abs/2403.17889
Publikováno v:
The NeurIPS 2023 Workshop on New Frontiers of AI for Drug Discovery and Development (AI4D3 2023), New Orleans, LA, USA, 2023
Designing reward functions that guide generative molecular design (GMD) algorithms to desirable areas of chemical space is of critical importance in AI-driven drug discovery. Traditionally, this has been a manual and error-prone task; the selection o
Externí odkaz:
http://arxiv.org/abs/2312.09865
Autor:
de Sá, Alex G. C., Gould, Daniel, Fedyukova, Anna, Nicholas, Mitchell, Dockrell, Lucy, Fletcher, Calvin, Pilcher, David, Capurro, Daniel, Ascher, David B., El-Khawas, Khaled, Pires, Douglas E. V.
The intensive care unit (ICU) comprises a complex hospital environment, where decisions made by clinicians have a high level of risk for the patients' lives. A comprehensive care pathway must then be followed to reduce p complications. Uncertain, com
Externí odkaz:
http://arxiv.org/abs/2309.13781
Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens. The effectiveness of antigen neutralisation and elimination hinges upon the strength, sensitivity, and specificity of the paratope-epitope interac
Externí odkaz:
http://arxiv.org/abs/2309.01122
We propose an approach for adapting the DeBERTa model for electronic health record (EHR) tasks using domain adaptation. We pretrain a small DeBERTa model on a dataset consisting of MIMIC-III discharge summaries, clinical notes, radiology reports, and
Externí odkaz:
http://arxiv.org/abs/2303.14920
Publikováno v:
BMC Bioinformatics 23, 4 (2022)
Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways. However, only 4% of PPIs are annotated with PTMs in biological knowledge databases such as IntAct, mainly performed through manual
Externí odkaz:
http://arxiv.org/abs/2201.02229
Publikováno v:
In Computational and Structural Biotechnology Journal December 2024 23:3030-3039
The proliferation of early diagnostic technologies, including self-monitoring systems and wearables, coupled with the application of these technologies on large segments of healthy populations may significantly aggravate the problem of overdiagnosis.
Externí odkaz:
http://arxiv.org/abs/2107.10399
Publikováno v:
In Current Opinion in Pharmacology February 2024 74
Publikováno v:
In Journal of Biomedical Informatics November 2023 147