Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Piperidines/pharmacology"'
1
Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making
Autor: Soghra Hesam, Abbas Haghparast, Enrike G. Argandoña, Gregor Rainer, Mojtaba Kermani, Abbas Khani
Publikováno v: Psychopharmacology, Vol. 232, No 12 (2015) pp. 2097-112
Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during cost-benefit decision making in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7143121d4609402146180aa43ec96151
http://doc.rero.ch/record/331752/files/213_2014_Article_3841.pdf
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2
Amalaki Rasayana improved memory and neuronal metabolic activity in AβPP-PS1 mouse model of Alzheimer’s disease
Autor: Jedy Jose, Pandichelvam Veeraiah, Subhash C. Lakhotia, Vivek Tiwari, Kamal Saba, Anant B. Patel
Publikováno v: Journal of Biosciences, 42(3), 363-371. Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive loss of memory and cognitive function. The cerebral metabolic rate of glucose oxidation has been shown to be reduced in AD. The present study evaluate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6ff524e184f5ad6bee5209ae2ae5c
https://doi.org/10.1007/s12038-017-9692-7
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3
Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study
Autor: Alice T. Shaw, Shirish M. Gadgeel, Solange Peters, S-H.I. Ou, Silvia Novello, Ali Zeaiter, Maurice Pérol, Anna Wrona, D.R. Camidge, Dong Wan Kim, Bogdana Balas, Eveline Nüesch, Ting Liu, Tony Mok, Rafael Rosell
Publikováno v: Annals of oncology, vol. 29, no. 11, pp. 2214-2222
The phase III ALEX study in patients with treatment-naive advanced anaplastic lymphoma kinase mutation-positive (ALK+) non-small-cell lung cancer (NSCLC) met its primary end point of improved progression-free survival (PFS) with alectinib versus criz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202d9467b40c9c8632a07affb6261137
https://pubmed.ncbi.nlm.nih.gov/30239586
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4
Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)
Autor: Rahman, Anisur, Lamberty, Yves, Schenker, Esther, Cella, Massimo, Languille, Solène, Bordet, Régis, Richardson, Jill, Pifferi, Fabien, Aujard, Fabienne
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
PLoS ONE, Vol 12, Iss 9, p e0184822 (2017)
PLoS ONE, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
International audience; The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Cur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5b74e29145b18039d08a2d3175427a8
https://pubmed.ncbi.nlm.nih.gov/28922421
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5
Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice
Autor: Inga Bauer, Sébastien Lenglet, Fabrizio Montecucco, Sabine Steffens, Franco Patrone, Nicolas Vuilleumier, Graziano Pelli, Fabienne Burger, Nikolaos Stergiopulos, Alessandra Quercioli, Rodrigo A. Fraga-Silva, Rafaela F. da Silva, Maria Bertolotto, Irene Caffa, Franco Dallegri, Sara Vazquez Calvo, Robson A.S. Santos, Mathias Fabre, Alessio Nencioni, François Mach, Katia Galan, Alberto Ballestrero, Santina Bruzzone, Mirko Magnone, Giovanna Sociali
Publikováno v: Thrombosis and Haemostasis; Vol 111
Thrombosis and Haemostasis, Vol. 111, No 2 (2014) pp. 308-322
Thrombosis and Haemostasis
Thrombosis and haemostasis
SummaryPharmacological treatments targeting CXC chemokines and the associated neutrophil activation and recruitment into atherosclerotic plaques hold promise for treating cardiovascular disorders. Therefore, we investigated whether FK866, a nicotinam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b375eb96d2dee546cb24fc9a6df1f1de
https://doi.org/10.1160/th13-07-0531
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6
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model
Autor: Laura Emionite, Santina Bruzzone, Federica Zamporlini, Nadia Raffaelli, Giovanna Bianchi, Aimable Nahimana, Laura Sturla, Mirko Magnone, Tiziana Vigliarolo, Giovanna Sociali, Alessio Nencioni, Lizzia Raffaghello
Publikováno v: Oncotarget, vol. 7, no. 3, pp. 2968-2984
Oncotarget
// Giovanna Sociali 1, * , Lizzia Raffaghello 2, * , Mirko Magnone 1 , Federica Zamporlini 3 , Laura Emionite 4 , Laura Sturla 1 , Giovanna Bianchi 2 , Tiziana Vigliarolo 1 , Aimable Nahimana 5 , Alessio Nencioni 6, 7 , Nadia Raffaelli 3 , Santina Br
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efff9d87d8a751a1e93561a5c11bfe4
https://serval.unil.ch/notice/serval:BIB_93788DFD2BBE
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7
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers
Autor: Fabienne Dulin, Noé Dumas, Céline Ballandonne, Christine Fossey, Thomas Cailly, Emmanuelle Dubost, Frédéric Fabis, Rosa Magnelli, Jana Sopkova de-Oliveira Santos, Sabrina Butt-Gueulle, Philippe Millet, Yves Charnay, Sylvain Rault, Daniel H. Caignard
Publikováno v: Journal of medicinal chemistry
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9693-9707. ⟨10.1021/jm300943r⟩
Journal of Medicinal Chemistry, Vol. 55, No 22 (2012) pp. 9693-9707
The work described herein aims at finding new potential ligands for the brain imaging of 5-HT(4) receptors (5-HT(4)Rs) using single-photon emission computed tomography (SPECT). Starting from the nonsubstituted phenanthridine compound 4a, exhibiting a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0bdc3552310c4e0bed411a9c10bb52
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8
Pharmacological Inhibition of CB1Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity
Autor: Norma P. Gerard, George Kunos, Partha Mukhopadhyay, Mohanraj Rajesh, Pal Pacher, Zsuzsanna K. Zsengellér, Sandor Batkai, Nora Czifra, Judith Harvey-White, Lucas Liaudet, György Haskó
Publikováno v: Journal of the American College of Cardiology, vol. 50, no. 6, pp. 528-36
Objectives We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity. Background Doxorubicin is one of the most potent antitumor agents avail
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08e21e52c6e63f9e617b62a6caa6651
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9
Coordination of Transcription Factor Phosphorylation and Histone Methylation by the P-TEFb Kinase during Human Immunodeficiency Virus Type 1 Transcription
Autor: Ajit Kumar, Fatah Kashanchi, Meisheng Zhou, Longwen Deng, Anne Pumfery, Hyeon Ung Park, Vincent Lacoste, John N. Brady
Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2004, 78 (24), pp.13522-13533. ⟨10.1128/JVI.78.24.13522-13533.2004⟩
The human immunodeficiency virus type 1 (HIV-1) Tat protein recruits positive transcription elongation factor b (P-TEFb) to the transactivation response (TAR) RNA structure to facilitate formation of processive transcription elongation complexes (TEC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c3252b2ce863e749e4d2792390dd08
https://doi.org/10.1128/jvi.78.24.13522-13533.2004
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10
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis
Autor: Somi Reddy Majjigapu, Anne Julie Cloux, Aimable Nahimana, Coralie Rummel, Julien Puyal, Alessio Nencioni, Michel A. Duchosal, Dominique Aubry, Vanessa Ginet, Caroline S. Breton, Pierre Vogel, Santina Bruzzone, Bernard Sordat
Publikováno v: Autophagy, vol. 10, no. 4, pp. 603-617
APO866, an inhibitor of NAD biosynthesis, exhibits potent antitumor properties in various malignancies. Recently, it has been shown that APO866 induces apoptosis and autophagy in human hematological cancer cells, but the role of autophagy in APO866-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3484b3dd6cf0f43f6f542c96649afd
https://pubmed.ncbi.nlm.nih.gov/24487122
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