Zobrazeno 1 - 10
of 1 634
pro vyhledávání: '"Piper M"'
Autor:
Elizabeth Gray, Kelly Hensley, Sean Allred, Robert Thurman, Katie Snead, Michelle Ulrich, Dannah Miller, Serena Wo, Angela Epp, Disha Sahetya, Julie Hahn, Chris Frantz, Natalya Nazarenko, Kellie Spahr, Patrick Younan, Li-Ya Huang, Kristen Gahnberg, Piper M Treuting, Esther S Trueblood, John J Gosink, Evgenia Jane Haass, Mary Padilla, Alyson J Smith, Jason P Schrum, Shyra J Gardai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl
Externí odkaz:
https://doaj.org/article/f885976e5e104e04a8016c6dbb713fb4
Autor:
Stacey M Meeker, Kevin S Mears, Naseer Sangwan, Mitchell J Brittnacher, Eli J Weiss, Piper M Treuting, Nicholas Tolley, Christopher E Pope, Kyle R Hager, Anh T Vo, Jisun Paik, Charles W Frevert, Hillary S Hayden, Lucas R Hoffman, Samuel I Miller, Adeline M Hajjar
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008251 (2020)
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI inflammation and nutrient malabsorptio
Externí odkaz:
https://doaj.org/article/a071568799924354a179ea30319fdea7
Autor:
Kathryn McGuckin Wuertz, Piper M Treuting, Emily A Hemann, Katharina Esser-Nobis, Annelise G Snyder, Jessica B Graham, Brian P Daniels, Courtney Wilkins, Jessica M Snyder, Kathleen M Voss, Andrew Oberst, Jennifer Lund, Michael Gale
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007899 (2019)
West Nile Virus (WNV), an emerging and re-emerging RNA virus, is the leading source of arboviral encephalitic morbidity and mortality in the United States. WNV infections are acutely controlled by innate immunity in peripheral tissues outside of the
Externí odkaz:
https://doaj.org/article/5b1fd2c0b9da4919aee0c9299e0572e0
Autor:
Audrey Seamons, Michael Haenisch, Stacey Meeker, Olesya Pershutkina, Thea Brabb, Piper M. Treuting, Jisun Paik
Publikováno v:
Nutrients, Vol 12, Iss 10, p 2927 (2020)
Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) reg
Externí odkaz:
https://doaj.org/article/88c5397063bc4ae6be8df4735e5d1bb6
Autor:
Carrie M Rosenberger, Rebecca L Podyminogin, Alan H Diercks, Piper M Treuting, Jacques J Peschon, David Rodriguez, Madhumati Gundapuneni, Mitchell J Weiss, Alan Aderem
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006305 (2017)
Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that suppress
Externí odkaz:
https://doaj.org/article/7f6a90ffdcf348dd84d598fa7874b765
Autor:
Jessica B Graham, Jessica L Swarts, Courtney Wilkins, Sunil Thomas, Richard Green, Aimee Sekine, Kathleen M Voss, Renee C Ireton, Michael Mooney, Gabrielle Choonoo, Darla R Miller, Piper M Treuting, Fernando Pardo Manuel de Villena, Martin T Ferris, Shannon McWeeney, Michael Gale, Jennifer M Lund
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005996 (2016)
Infection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV infection has precluded identification of the immune events contributing to persistent infectio
Externí odkaz:
https://doaj.org/article/1368135a2e7e452780f93435ca1dd3a6
Autor:
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith, Daniel Meza, Masanao Yajima, Richard P Beyer, Kathleen F Kerr, Daniel J Davis, Catherine H Gillespie, Jessica M Snyder, Piper M Treuting, Matt Kaeberlein
Publikováno v:
eLife, Vol 5 (2016)
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy
Externí odkaz:
https://doaj.org/article/789d01e84d514ea888c6cbb9326c49be
Autor:
Jessica B. Graham, Sunil Thomas, Jessica Swarts, Aimee A. McMillan, Martin T. Ferris, Mehul S. Suthar, Piper M. Treuting, Renee Ireton, Michael Gale, Jennifer M. Lund
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune responses to WNV infection have been well studied in C57BL/6J inbred mice, but this m
Externí odkaz:
https://doaj.org/article/65d31289859044929ba15da991eaaa1b
Autor:
Jessica M Snyder, Piper M Treuting, Lee Nagy, Cathy Yam, Jaehun Yi, Alicia Brasfield, Lisa Phuong Anh Nguyen, Adeline M Hajjar
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107257 (2014)
A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants. The mice developed a spontaneous immune-mediated phenotype prior to six months of age characterized by runting, lethargy, blepharitis, a
Externí odkaz:
https://doaj.org/article/90ba677b9f8549cda5fa2f8b33800789
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79182 (2013)
There are few mouse models that adequately mimic large bowel cancer in humans or the gastrointestinal inflammation which frequently precedes it. Dextran sodium sulphate (DSS)-induces colitis in many animal models and has been used in combination with
Externí odkaz:
https://doaj.org/article/6e37e64eeb1a4c248d72aa4afa729804