Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Piotr Zimniak"'
Autor:
Colin T. Shearn, Kristofer S. Fritz, Alisabeth H. Shearn, Laura M. Saba, Kelly E. Mercer, Bridgette Engi, James J. Galligan, Piotr Zimniak, David J. Orlicky, Martin J. Ronis, Dennis R. Petersen
Publikováno v:
Redox Biology, Vol 7, Iss C, Pp 68-77 (2016)
Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by h
Externí odkaz:
https://doaj.org/article/a0c8a20508814e5c97a8857b03dd80be
The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.
Autor:
Billow A Ahmed, Irfan A Bukhari, Brandon C Jeffus, Justin T Harney, Sheeno Thyparambil, Endrit Ziu, Mony Fraer, Nancy J Rusch, Piotr Zimniak, Vladimir Lupashin, Dale Tang, Fusun Kilic
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4730 (2009)
BACKGROUND:The C-terminus of the serotonin transporter (SERT) contains binding domains for different proteins and is critical for its functional expression. In endogenous and heterologous expression systems, our proteomic and biochemical analysis dem
Externí odkaz:
https://doaj.org/article/e92dc1d42a694d39b32a7e31ed566e0d
Autor:
Alisabeth H. Shearn, David J. Orlicky, Bridgette Engi, Kelly E. Mercer, Dennis R. Petersen, Piotr Zimniak, Colin T. Shearn, James J. Galligan, Martin J. J. Ronis, Laura Saba, Kristofer S. Fritz
Publikováno v:
Redox Biology, Vol 7, Iss C, Pp 68-77 (2016)
Redox Biology
Redox Biology
Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf0472da6658abcc58ba6a17661d04c
http://www.sciencedirect.com/science/article/pii/S2213231715300148
http://www.sciencedirect.com/science/article/pii/S2213231715300148
Autor:
Kelly E. Mercer, David J. Orlicky, Bridgette Engi, Martin J. J. Ronis, Emanuele Albano, Piotr Zimniak, Dennis R. Petersen, Thomas M. Badger, Brenda M. Gannon, Colin T. Shearn
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G403-G415
To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4–4-null (GSTA4−/−) mice for 40 days. GSTA4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c8ec30492240ec2a97133efbde6bc7
https://doi.org/10.1152/ajpgi.00154.2014
https://doi.org/10.1152/ajpgi.00154.2014
Publikováno v:
Frontiers in bioscience : a journal and virtual library. 2
Transport mechanisms involved in the exclusion of xeno- and endobiotic toxins from the cellular environment play a crucial role in protecting cells from toxicity of these compounds. A transporter designated as dinitrophenyl S-glutathione ATPase (DNP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a27d9981347f1489f901ddc61cde08
https://pubmed.ncbi.nlm.nih.gov/28481204
https://pubmed.ncbi.nlm.nih.gov/28481204
Autor:
Dennis R. Petersen, Kelly E. Mercer, Casey F. Pulliam, Thomas M. Badger, Bridgette Engi, Martin J. J. Ronis, Colin T. Shearn, Piotr Zimniak, Leah Hennings
We established a mouse model of developmental nonalcoholic steatohepatitis (NASH) by feeding a high polyunsaturated fat liquid diet to female glutathione-S-transferase 4-4 (Gsta4−/−)/peroxisome proliferator activated receptor α (Ppara−/−) do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3047a13e81906d260e68077a38850b3
https://europepmc.org/articles/PMC5389362/
https://europepmc.org/articles/PMC5389362/
Autor:
John J. Thaden, Lulu Xu, Piotr Zimniak, Cagdas Tazearslan, Eric R. Siegel, Robert J. Shmookler Reis, Srinivas Ayyadevara, Ramani Alla, Puneet Bharill, Minho Chae, Hoonyong Lee
Publikováno v:
Aging. 3:125-147
Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability to produce free-radical chain reactions. For t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6c23a7a18e4a55b3fa0c414da1309c
https://doi.org/10.18632/aging.100275
https://doi.org/10.18632/aging.100275
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1800:16-22
Background Of the five human Alpha-class glutathione transferases, expression of hGSTA5 has not been experimentally documented, even though in silico the hGSTA5 sequence can be assembled into a mRNA and translated. The present work was undertaken to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b0512ece0266d826f2df29b874cfd5
https://doi.org/10.1016/j.bbagen.2009.07.025
https://doi.org/10.1016/j.bbagen.2009.07.025
Autor:
Yogesh C. Awasthi, Seema Dwivedi, Abha Sharma, Rajendra Sharma, Piotr Zimniak, Sanjay Awasthi
Publikováno v:
Biochemistry. 47:143-156
Previously, we have shown that 4-hydroxynonenal (4-HNE) induces Fas-mediated apoptosis in HLE B-3 cells through a pathway which is independent of FasL, FADD, procaspase 8, and DISC (Li, J., et al. (2006) Biochemistry 45, 12253-12264). The involvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0717ccbd43ede227f0a5213a5bac0a24
https://doi.org/10.1021/bi701559f
https://doi.org/10.1021/bi701559f
Autor:
Ying Mu, David Toma, Haibiao Gong, Jung Hoon Lee, S. P. S. Saini, Valerian E. Kagan, Billy W. Day, Shivendra V. Singh, Wen Xie, Sharda P. Singh, Piotr Zimniak, Songrong Ren
Publikováno v:
Molecular Endocrinology. 20:279-290
Efficient handling of oxidative stress is critical for the survival of organisms. The orphan nuclear receptor pregnane X receptor (PXR) is important in xenobiotic detoxification through its regulation of phase I and phase II drug-metabolizing/detoxif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05133ccf4f52ea5eca25b1e3ba41e416
https://doi.org/10.1210/me.2005-0205
https://doi.org/10.1210/me.2005-0205