Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain and Modulation via Direct Interactions with DNA Abasic Sites: Understanding the Mechanisms Involved in Castration-Resistant Prostate Cancer

Autor: Shangze Xu, Matthew D. Kondal, Ayaz Ahmad, Ruidi Zhu, Lanyu Fan, Piotr Zaborniak, Katrina S. Madden, João V. de Souza, Agnieszka K. Bronowska

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 1270 (2023)

The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration-resistant prostate cancer (CRPC). A significant challenge in designing effective drugs lies in targeting constitutively active AR variants and, most

Externí odkaz: https://doaj.org/article/f97ec6fe8c5040408f164ec743092487

'Druggability' of the PAS domains of human PASK kinase, a therapeutic target for metabolic and liver disorders

Autor: Shangze Xu, Lanyu Fan, Piotr Zaborniak, Ruidi Zhu, Haoyuan Ji, Katrina S. Madden, João V. de Souza, Agnieszka K. Bronowska

Publikováno v: QRB Discovery, Pp 1-21

Externí odkaz: https://doaj.org/article/8435fcc907da408ab36b5a9600348edc

Study on the Properties of Immobilized Biocatalysts with Lipase Activity Produced by Yarrowia lipolytica in Batch Culture

Autor: Agata Fabiszewska, I. Stolarzewicz, Ewa Białecka-Florjańczyk, Piotr Zaborniak

Publikováno v: Chemical and Biochemical Engineering Quarterly, Vol 31, Iss 3, Pp 251-259 (2017)
Chemical and Biochemical Engineering Quarterly
Volume 31
Issue 3

Three kinds of matrices (calcium alginate, gelatin, and PVA) were employed as supports to immobilize lipases from Y. lipolytica KKP 379 via physical adsorption. The stability of biocatalysts (free and immobilized) was evaluated by measuring the enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfab9e2c6825f55e63d2be07221971c
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