Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Piotr Topolewski"'
Publikováno v:
Cancer Research. 83:LB176-LB176
Introduction: Immune Checkpoint Inhibition (ICI) therapies have demonstrated significant clinical success in multiple cancer types. However, many patients do not develop durable responses to ICI treatments and the underlying mechanisms of action are
Autor:
Piotr Topolewski, Karolina E. Zakrzewska, Jarosław Walczak, Karol Nienałtowski, Gerhard Müller-Newen, Abhyudai Singh, Michał Komorowski
Publikováno v:
Science signaling. 15(721)
Cellular signaling responses show substantial cell-to-cell heterogeneity, which is often ascribed to the inherent randomness of biochemical reactions, termed molecular noise, wherein high noise implies low signaling fidelity. Alternatively, heterogen
Autor:
Michał Komorowski, Piotr Topolewski
Publikováno v:
Current Opinion in Systems Biology. 27:100352
An individual eukaryotic cell senses identity and quantity of ligands through molecular receptors and signaling pathways, dynamically activating signaling effectors. A distinct ligand often activates multiple different effectors, and a distinct effec
Publikováno v:
Mikrochimica Acta. 97:75-80
The dissociation constants of rutin in aqueous-methanol medium (60∶40 v/v), the values of which are pK1=−2.92±0.06, pK2=6.72±0.11, pK3=8.26±0.05, pK4=12.57±0.09, were estimated by using the spectrophotometric method. They were ascribed to the
Publikováno v:
Microchemical Journal. 35:145-152
A new spectrophotometric method for determining fluorine by rutin-zirconium(IV) complex was worked out. The optimum conditions of determination were established: aqueous-methanol medium (H 2 O:MeOH = 60:40( v / v )), containing HClO 4 at concentratio