Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Piotr Tobiasz"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6155 (2024)
The synthesis of biphenylmethoxydibenzo[b,f]oxepine or photoswitchable fluorinated dibenzo[b,f]oxepine derivatives with one or three azo bonds, potential microtubule inhibitors, is described. Our studies provide a concise method for constructing deri
Externí odkaz:
https://doaj.org/article/6ff08ad5791f4d69ad18247942eab6ec
Publikováno v:
Cells, Vol 12, Iss 14, p 1866 (2023)
Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications. However, their main disadvantage is the lack
Externí odkaz:
https://doaj.org/article/89451c7953d34f2dbfb34efdc2c652ce
Publikováno v:
Molecules, Vol 28, Iss 8, p 3558 (2023)
Cancer is one of the most common causes of human death worldwide; thus, numerous therapies, including chemotherapy, have been and are being continuously developed. In cancer cells, an aberrant mitotic spindle—a microtubule-based structure necessary
Externí odkaz:
https://doaj.org/article/bbe36f7a633d428bb344c4e372463727
Publikováno v:
Molecules, Vol 27, Iss 18, p 5836 (2022)
Dibenzo[b, f]oxepine derivatives are an important scaffold in natural, medicinal chemistry, and these derivatives occur in several medicinally relevant plants. Two dibenzo[b, f]oxepines were selected and connected with appropriate fluorine azobenzene
Externí odkaz:
https://doaj.org/article/e5a712cf8cbe4e9baa40045f334fd009
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 110973- (2021)
Microtubules (composed of α- and β-tubulin heterodimers) ubiquitous cellular polymers are important components of the cytoskeleton and play diverse roles within the cell, such as maintenance of cell structure, protein trafficking or chromosomal seg
Externí odkaz:
https://doaj.org/article/aa3381a9c4214572b1a9a62c25cc1a89
Autor:
Damian Garbicz, Piotr Tobiasz, Filip Borys, Tomasz Pilżys, Michał Marcinkowski, Marcin Poterała, Elżbieta Grzesiuk, Hanna Krawczyk
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 123, Iss , Pp 109781- (2020)
In the present study, the synthesis and cytotoxic effect of six stilbenes and three oxepine derivatives against two cancerous – HeLa and U87, and two normal – EUFA30 and HEK293 cell lines has been reported. The results of cytotoxic assay and flow
Externí odkaz:
https://doaj.org/article/d750c2163e8544a5be79827be82252bd
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11033 (2021)
The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF
Externí odkaz:
https://doaj.org/article/3cbedd1bff24481a9e84ca60f829e8f4
Autor:
Piotr Tobiasz
Publikováno v:
Wiadomości Chemiczne. 75:1237-1257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2563cc60e622cfd65f9390f980bf4fcb
https://doi.org/10.53584/wiadchem.2021.12.5
https://doi.org/10.53584/wiadchem.2021.12.5
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss, Pp 110973-(2021)
Microtubules (composed of α- and β-tubulin heterodimers) ubiquitous cellular polymers are important components of the cytoskeleton and play diverse roles within the cell, such as maintenance of cell structure, protein trafficking or chromosomal seg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924bfc8afbf6d1f172611f59787d7d54
https://pubmed.ncbi.nlm.nih.gov/33378993
https://pubmed.ncbi.nlm.nih.gov/33378993
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11033, p 11033 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 11033, p 11033 (2021)
The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92af01ba93a5c46c5b7fdd9a4d782487
https://doi.org/10.3390/ijms222011033
https://doi.org/10.3390/ijms222011033