Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Piotr Swiderski"'
Autor:
Jeremy Hall, Zhuoran Zhang, Supriyo Bhattacharya, Dongfang Wang, Marice Alcantara, Yong Liang, Piotr Swiderski, Stephen Forman, Larry Kwak, Nagarajan Vaidehi, Marcin Kortylewski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102137- (2024)
Decoy oligodeoxynucleotides (ODNs) allow targeting undruggable transcription factors, such as STAT3, but their limited potency and lack of delivery methods hampered translation. To overcome these challenges, we conjugated a STAT3-specific decoy to th
Externí odkaz:
https://doaj.org/article/131de0a661da4c95890883064a5927cd
Autor:
Bin Zhang, Dandan Zhao, Fang Chen, David Frankhouser, Huafeng Wang, Khyatiben V. Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang, Min-Hsuan Chen, Shu Tao, Hyejin Cho, Yong Liang, Danilo Perrotti, Sergio Branciamore, Russell Rockne, Xiwei Wu, Lucy Ghoda, Ling Li, Jie Jin, Jianjun Chen, Jianhua Yu, Michael A. Caligiuri, Ya-Huei Kuo, Mark Boldin, Rui Su, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34+CD38− blasts from BC CML patients than in t
Externí odkaz:
https://doaj.org/article/883dc5faaf3c4abe8121ce71d3dc31ce
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Autor:
Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Marie Gonzaga, Kokilah Muthaiyah, Piotr Swiderski, Karen S. Aboody, Marcin Kortylewski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 611-620 (2022)
Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and
Externí odkaz:
https://doaj.org/article/2c3ff6cf67da44afa64366d79036cbde
Autor:
Lianjun Zhang, Le Xuan Truong Nguyen, Ying-Chieh Chen, Dijiong Wu, Guerry J. Cook, Dinh Hoa Hoang, Casey J. Brewer, Xin He, Haojie Dong, Shu Li, Man Li, Dandan Zhao, Jing Qi, Wei-Kai Hua, Qi Cai, Emily Carnahan, Wei Chen, Xiwei Wu, Piotr Swiderski, Russell C. Rockne, Marcin Kortylewski, Ling Li, Bin Zhang, Guido Marcucci, Ya-Huei Kuo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
miR-126 is highly expressed in inv(16) Acute myeloid leukemia (AML) but its role is unclear. Here, the authors show that the aberrant expression of miR-126 in inv(16) AML is directly due to the CBFB-MYH11 fusion gene and that it can promote AML devel
Externí odkaz:
https://doaj.org/article/ba8150db19cd424e95fcc1bef2ef61ff
Autor:
Sorah Yoon, Kai-Wen Huang, Pinelopi Andrikakou, Daniel Vasconcelos, Piotr Swiderski, Vikash Reebye, Mikael Sodergren, Nagy Habib, John J. Rossi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 142-154 (2019)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease. In previous studies, small activating RNA against CCAAT/enhancer-binding
Externí odkaz:
https://doaj.org/article/f078dc1a190a446fbb68d265bc835522
Autor:
Silvia Nuzzo, Silvia Catuogno, Maria Capuozzo, Alfonso Fiorelli, Piotr Swiderski, Serena Boccella, Filomena de Nigris, Carla Lucia Esposito
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 256-263 (2019)
Non-small-cell lung cancer (NSCLC) accounts for 85%–90% of all cases of lung cancer that is the most deadly type of cancer. Despite advances in chemotherapy and radiotherapy, severe side effects and frequent drug resistance limit the success of the
Externí odkaz:
https://doaj.org/article/a85c657154e04d3d8811c3e693d25318
Autor:
Sorah Yoon, Kai-Wen Huang, Vikash Reebye, Duncan Spalding, Teresa M. Przytycka, Yijie Wang, Piotr Swiderski, Lin Li, Brian Armstrong, Isabella Reccia, Dimitris Zacharoulis, Konstantinos Dimas, Tomokazu Kusano, John Shively, Nagy Habib, John J. Rossi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 80-88 (2017)
Aptamer-drug conjugates (ApDCs) have the potential to improve the therapeutic index of traditional chemotherapeutic agents due to their ability to deliver cytotoxic drugs specifically to cancer cells while sparing normal cells. This study reports on
Externí odkaz:
https://doaj.org/article/f010d89398944530bdf4cfe7473aa72b
Publikováno v:
BioTechniques, Vol 33, Iss 1, Pp 129-138 (2002)
The error rate of conventional PCR is problematic when amplifying from single cells or amplifying segments for protein functional analysis by in vitro translation. We describe truncated amplification, a method for high-fidelity amplification in which
Externí odkaz:
https://doaj.org/article/726d750e93cd431da24ace5ebdf315c7
Autor:
Marcin Kortylewski, Sumanta K. Pal, Ronald A. DePinho, Xin Lu, Piotr Swiderski, Seok Voon White, Zhuoran Zhang, Yu-Lin Su, Xingli Zhao, Tomasz Adamus, Dayson Moreira
Different inhibitors of endocytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dc479ced682bbe023a9665263105d2
https://doi.org/10.1158/1078-0432.22470665
https://doi.org/10.1158/1078-0432.22470665
