Výsledky vyhledávání - "Piotr Miziak"

1-Aminobenzocyclobutene-1-phosphonic Acid and Related Compounds as Inhibitors of Phenylalanine Ammonia-Lyase

Autor: Jerzy Zoń, Piotr Miziak

Publikováno v: Chemistry & Biodiversity. 14:e1600488

Five new geminal aminocycloalkanephosphonic acids (4 - 8) containing both an aromatic ring and a cycloalkane ring were synthesized and evaluated as potential inhibitors of buckwheat phenylalanine ammonia-lyase (PAL). Within the set of compounds which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70ae1b0ce37a92bb2817afbdf615a04
https://doi.org/10.1002/cbdv.201600488

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Inhibitors of phenylalanine ammonia-lyase (PAL): synthesis and biological evaluation of 5-substituted 2-aminoindane-2-phosphonic acids

Autor: Jerzy Zoń, Roman Gancarz, Piotr Miziak, Nikolaus Amrhein

Publikováno v: Chemistrybiodiversity. 2(9)

A series of 5-substituted derivatives of the potent phenylalanine ammonia-lyase (PAL) inhibitor 2-aminoindane-2-phosphonic acid (AIP; 2) were synthesized. The AIP analogues 3-7, with additional NO 2 , NH 2 , Me, Br, and OH groups, respectively, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8388d5db0cd6b7138561f3ee82f35aa8
https://pubmed.ncbi.nlm.nih.gov/17193201

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Inhibitors of phenylalanine ammonia-lyase: substituted derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid

Autor: Roman Gancarz, Nikolaus Amrhein, Jerzy Zoń, Piotr Miziak

Publikováno v: Phytochemistry. 68(4)

Six derivatives of 2-aminoindane-2-phosphonic acid and 1-aminobenzylphosphonic acid were synthesized. The compounds were tested both as inhibitors of buckwheat phenylalanine ammonia-lyase (in vitro) and as inhibitors of anthocyanin biosynthesis (in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877c6f9252d4db585c8fb7cc7baf0b55
https://pubmed.ncbi.nlm.nih.gov/17215011

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Experimental and ab initio calculated structures of 2-aminoindane-2-phosphonic acid, a potent inhibitor of phenylalanine ammonia-lyase, and theoretical studies of its binding to the model enzyme structureElectronic supplementary information (ESI) available: bond lengths and angles for 1 and 2, selected infrared frequencies and their assignment for 1 and 1D4, geometries of different conformations of 1 in various protonation states, optimized at different levels of theory. See http://www.rsc.org/suppdata/nj/b3/b307533h

Autor: Jerzy Zoń, Rafał Latajka, Borys Szefczyk, Wojciech Szczepanik, Wanda Sawka-Dobrowolska, Nikolaus Amrhein, Piotr Miziak, Maria Kucharska-Zon, Roman Gancarz

Publikováno v: New Journal of Chemistry. 28:1048

The structure of 2-aminoindane-2-phosphonic acid (AIP) was studied using X-ray crystallography, NMR spectroscopy, molecular modelling, IR spectroscopy, and potentiometric titration. In the solid state, a thermodynamically stable conformer of AIP is o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::422bdeae4c394ffd332b968da5ed129f
https://doi.org/10.1039/b307533h

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