Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Piotr Leonczak"'
Autor:
Piet Herdewijn, Piotr Leonczak, Guy Schepers, Omprakash Bande, Puneet Srivastava, Eveline Lescrinier
Publikováno v:
The Journal of Organic Chemistry. 84:13394-13409
In this report, we present the synthesis of N8-glycosylated 8-aza-2-methylhypoxanthine and 8-aza-6-thiohypoxanthine 2'-deoxynucleosides as well as methylated 2'-deoxynebularine derivatives. In vitro base pairing properties between each modified and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d261cfa544de67087ab69206c697679
https://doi.org/10.1021/acs.joc.9b01576
https://doi.org/10.1021/acs.joc.9b01576
Autor:
Guy Schepers, Piet Herdewijn, Vitor B. Pinheiro, Mikhail Abramov, Marleen Renders, Jef Rozenski, Donaat Kestemont, Piotr Leonczak
Publikováno v:
Chemical Communications
Chemical Communications, 2018, 54 (49), pp.6408-6411. ⟨10.1039/c8cc02414f⟩
Chemical Communications, Royal Society of Chemistry, 2018, 54 (49), pp.6408-6411. ⟨10.1039/c8cc02414f⟩
Chemical Communications, 2018, 54 (49), pp.6408-6411. ⟨10.1039/c8cc02414f⟩
Chemical Communications, Royal Society of Chemistry, 2018, 54 (49), pp.6408-6411. ⟨10.1039/c8cc02414f⟩
T4 DNA ligase is capable of ligating 2'OMe-RNA duplexes, HNA, LNA and FANA mixed sequences in the presence of 10% w/v PEG8000 and 3 M betaine. The enzymatic joining of oligonucleotides containing multiple consecutive XNA nucleotides at the ligation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a087d9bbace9a78cebbcff683135f9
https://doi.org/10.1039/c8cc02414f
https://doi.org/10.1039/c8cc02414f
Autor:
Piet Herdewijn, Elisabetta Groaz, Guy Schepers, Faten Jaziri, Min Luo, Mathy Froeyen, Philippe Marliere, Jef Rozenski, Valérie Pezo, Piotr Leonczak
A synthetic orthogonal polymer embracing a chiral acyclic-phosphonate backbone [(S)-ZNA] is presented that uniquely adds to the emerging family of xenobiotic nucleic acids (XNAs). (S)-ZNA consists of reiterating six-atom structural units and can be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704287e79f883af8e0cff24ab2e27b7f
https://lirias.kuleuven.be/handle/123456789/639912
https://lirias.kuleuven.be/handle/123456789/639912
Autor:
Min, Luo, Elisabetta, Groaz, Mathy, Froeyen, Valérie, Pezo, Faten, Jaziri, Piotr, Leonczak, Guy, Schepers, Jef, Rozenski, Philippe, Marlière, Piet, Herdewijn
Publikováno v:
Journal of the American Chemical Society. 141(27)
A synthetic orthogonal polymer embracing a chiral acyclic-phosphonate backbone [(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c032f75eccd366bbe3f9965d2bc17656
https://pubmed.ncbi.nlm.nih.gov/31251601
https://pubmed.ncbi.nlm.nih.gov/31251601
Autor:
Anna Teresa Ramadori, Piet Herdewijn, Jef Rozenski, Ling-Jie Gao, Steven De Jonghe, Piotr Leonczak, Eveline Lescrinier
Publikováno v:
ChemMedChem. 9:2587-2601
In recent years, DAPK-related apoptosis-inducing protein kinase 2 (DRAK2) has emerged as a promising target for the treatment of a variety of autoimmune diseases and for the prevention of graft rejection after organ transplantation. However, medicina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834f0af21a129bc153748fb3d66d7afb
https://doi.org/10.1002/cmdc.201402234
https://doi.org/10.1002/cmdc.201402234
Publikováno v:
RNA. 20:938-947
5-Taurinomethyluridine (τm5U) and 5-taurinomethyl-2-thiouridine (τm5s2U) are located at the wobble position of human mitochondrial (hmt) tRNALeu(UUR) and tRNALys, respectively. Both hypermodified units restrict decoding of the third codon letter to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39683f8e3cf8e7861497726ae6b0963d
https://doi.org/10.1261/rna.044412.114
https://doi.org/10.1261/rna.044412.114
Publikováno v:
Tetrahedron Letters. 53:1214-1217
We present a reproducible protocol for the site-specific incorporation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) into a model RNA fragment and, together with 2-methyladenosine (m2A), into the native sequence of the Escherichia coli tRNAGlu2 anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a9c6036ae416232587679a5b34a86d9
https://doi.org/10.1016/j.tetlet.2011.12.079
https://doi.org/10.1016/j.tetlet.2011.12.079
Autor:
Piotr Leonczak, Christa E. Müller, Sang-Yong Lee, Jef Rozenski, Theodor Hanck, Lei Chang, Piet Herdewijn, Steven De Jonghe
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels. To study the (patho)physiological roles of NPP1 potent and selective inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacdc13845d3b32057eb472104347993
https://lirias.kuleuven.be/handle/123456789/472342
https://lirias.kuleuven.be/handle/123456789/472342
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85853d7c55edc8079172cad87742c3f9
https://doi.org/10.1135/css201414408
https://doi.org/10.1135/css201414408
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 32(11)
In this paper, we discuss the usefulness of reductive amination of 5-formyl-2',3'-O-isopropylidene(-2-thio)uridine with glycine or taurine esters in the presence of sodium triacetoxyborohydride (NaBH(OAc)3) for the synthesis of the native mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bcff6926fdb9656d47ad017f092292
https://pubmed.ncbi.nlm.nih.gov/24138499
https://pubmed.ncbi.nlm.nih.gov/24138499