Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Piotr Kozlowski"'
Autor:
Magdalena Ambrożek-Latecka, Piotr Kozlowski, Grażyna Hoser, Magdalena Bandyszewska, Karolina Hanusek, Dominika Nowis, Jakub Gołąb, Małgorzata Grzanka, Agnieszka Piekiełko-Witkowska, Luise Schulz, Franziska Hornung, Stefanie Deinhardt-Emmer, Ewa Kozlowska, Tomasz Skirecki
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Inflammasome assembly is a potent mechanism responsible for the host protection against pathogens, including viruses. When compromised, it can allow viral replication, while when disrupted, it can perpetuate pathological responses by IL-1 si
Externí odkaz:
https://doaj.org/article/98e3ed4e09be4e00bd7997b797d253b2
Autor:
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-t
Externí odkaz:
https://doaj.org/article/7f60fbce64114253a4fc70c967d52dd5
Autor:
Joanna Drozd-Sokolowska, Luuk Gras, Linda Koster, Rodrigo Martino, María Queralt Salas, Urpu Salmenniemi, Teresa Zudaire, Lucrecia Yañez, Mar Bellido, Matthew Collin, Martin Kaufmann, Piotr Kozlowski, Xavier Poiré, Christelle Ferra, Antònia Sampol, Keith M. O. Wilson, Anne Cairoli, Tobias Gedde-Dahl, Eric Deconinck, Milena Mirabile, Felipe Suarez, Kavita Raj, Michel van Gelder, Ibrahim Yakoub-Agha, Olivier Tournilhac, Donal P. McLornan
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/ad61bf4e936e49b5bf37ef1b596771db
Autor:
Paulina Galka-Marciniak, Zuzanna Kanduła, Adrian Tire, Wladyslaw Wegorek, Kinga Gwozdz-Bak, Luiza Handschuh, Maciej Giefing, Krzysztof Lewandowski, Piotr Kozlowski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract Recent data indicate that MIR142 is the most frequently mutated miRNA gene and one of the most frequently mutated noncoding elements in all cancers, with mutations occurring predominantly in blood cancers, especially diffuse large B-cell lym
Externí odkaz:
https://doaj.org/article/8863f654dec347469cfd96995acf5fdf
Autor:
Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase
Externí odkaz:
https://doaj.org/article/f64cd07c7c004a71a562cc8d487925a5
Autor:
Natalia Szóstak, Luiza Handschuh, Anna Samelak-Czajka, Katarzyna Tomela, Marcin Schmidt, Łukasz Pruss, Kaja Milanowska-Zabel, Piotr Kozlowski, Anna Philips
Publikováno v:
mSystems, Vol 8, Iss 2 (2023)
ABSTRACT Recent studies revealed a significant role of the gut fungal community in human health. Here, we investigated the content and variation of gut mycobiota among subjects from the European population. We explored the interplay between gut fungi
Externí odkaz:
https://doaj.org/article/9596680b8b944e82b6b461745fae6dda
Autor:
Piotr Kozlowski
Publikováno v:
Cells, Vol 12, Iss 20, p 2449 (2023)
ERH is a 100 to about 110 aa nuclear protein with unique primary and three-dimensional structures that are very conserved from simple eukaryotes to humans, albeit some species have lost its gene, with most higher fungi being a noteworthy example. Ini
Externí odkaz:
https://doaj.org/article/05e874c69a44452f8b0fb398d7ed14ff
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6443-6457 (2022)
MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate the expression of most genes. They are involved in regulating many physiological processes, and aberrations in the levels of different miRNAs play an important role in t
Externí odkaz:
https://doaj.org/article/475dee415b384f0bb2e9bc894f7d9536
Autor:
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic repro
Externí odkaz:
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101023- (2022)
Summary: Here, we present the miRMut protocol to annotate mutations found in miRNA genes based on whole-exome sequencing (WES) or whole-genome sequencing (WGS) results. The pipeline assigns mutation characteristics, including miRNA gene IDs (miRBase
Externí odkaz:
https://doaj.org/article/c93514aaded1443fa6b7b5e670ffd67d