Impact of urbanization-driven changes of the riverbeds on its ecological status evidenced by diatom communities – The negative side of the Anthropocene

Autor: Ewelina Szczepocka, Joanna Żelazna-Wieczorek, Piotr K. Zakrzewski

Publikováno v: Ecological Indicators, Vol 159, Iss , Pp 111706- (2024)

Hydromorphological transformations, which are characteristic of the Anthropocene epoch display a strong negative impact on urban water ecosystems. Therefore, there is a need to take action to minimize their negative effect when planning spatial devel

Externí odkaz: https://doaj.org/article/89ce68fdf44248acb7e16d5d24db32a3

Mitochondrial O-GlcNAc Transferase Interacts with and Modifies Many Proteins and Its Up-Regulation Affects Mitochondrial Function and Cellular Energy Homeostasis

Autor: Tony Lefebvre, Anna Krześlak, Anne-Sophie Vercoutter-Edouart, Joanna Oracz, Fabrice Bray, Grażyna Budryn, Piotr Ciesielski, Karolina Kozal, Dorota Żyżelewicz, Stéphanie Flament, Paweł Jóźwiak, Piotr K. Zakrzewski

Publikováno v: Cancers
Volume 13
Issue 12
Cancers, Vol 13, Iss 2956, p 2956 (2021)
Cancers, MDPI, 2021, 13 (12), pp.2956. ⟨10.3390/cancers13122956⟩
Cancers, 2021, 13 (12), pp.2956. ⟨10.3390/cancers13122956⟩

Simple Summary O-GlcNAcylation is a dynamic post-translational modification of proteins involved in the control of intracellular signaling pathways in response to changes in nutrient availability, especially glucose concentration. To date, most resea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2657a5ac070570be5294e843a9a8204
http://europepmc.org/articles/PMC8231590

Betaglycan Gene (TGFBR3) Polymorphism Is Associated with Increased Risk of Endometrial Cancer

Autor: Andrzej Semczuk, Wanda M. Krajewska, Katarzyna Wójcik-Krowiranda, Ewa Forma, Adam I. Cygankiewicz, Magdalena Bryś, Andrzej Bieńkiewicz, Piotr K. Zakrzewski

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 10
Journal of Clinical Medicine, Vol 9, Iss 3082, p 3082 (2020)

We investigated single nucleotide polymorphism (SNP) of the betaglycan gene (TGFBR3) encoding the TGF&beta
co-receptor in endometrial cancer (EC) and its association with betaglycan expression. The study group included 153 women diagnosed with E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763dc51c9e56953867654fa2e22d134a

Novel orally available salvinorin A analog PR-38 protects against experimental colitis and reduces abdominal pain in mice by interaction with opioid and cannabinoid receptors

Autor: Radzisław Kordek, Marta Sobczak, Jakub Fichna, Wanda M. Krajewska, Piotr K. Zakrzewski, PR Polepally, Adam I. Cygankiewicz, Jordan K. Zjawiony, Maciej Sałaga

Publikováno v: Biochemical Pharmacology. 92:618-626

Background Salvinorin A (SA) is a potent anti-inflammatory diterpene isolated from the Mexican plant S. divinorum. Recently we showed that the novel SA analog, PR-38 has an inhibitory effect on mouse gastrointestinal (GI) motility mediated by opioid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4e2a161085683ec19176f7141ae8fb
https://doi.org/10.1016/j.bcp.2014.09.018

Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)

Autor: Radzisław Kordek, Jakub Fichna, Hubert Zatorski, Ewa Małecka-Panas, Anna Mokrowiecka, Martin Storr, Marta Sobczak, Wanda M. Krajewska, Piotr K. Zakrzewski, Maciej Sałaga, Emma Leishman, Heather B. Bradshaw, Adam I. Cygankiewicz

Publikováno v: Journal of Crohn's and Colitis. 8:998-1009

Pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBD) is currently one of the biggest challenge in the field of gastroenterology. Available therapies are mostly limited to overcoming the symptoms, but not the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872ed528e88e6ed712f4aadd26dc123c
https://doi.org/10.1016/j.crohns.2014.01.025