Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Piotr Guga"'
Publikováno v:
Applied Sciences, Vol 11, Iss 24, p 12125 (2021)
This review summarizes the synthetic efforts on acyclic analogs of nucleic acids and provides information on the most interesting features of selected classes of such compounds. The selection includes the following types of analogs: Flexible (FNA), U
Externí odkaz:
https://doaj.org/article/7e7087c0f068499f81165c29e2fa9b08
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008193 (2019)
Mechanisms for highly efficient chromosome-associated equal segregation, and for maintenance of steady state copy number, are at the heart of the evolutionary success of the 2-micron plasmid as a stable multi-copy extra-chromosomal selfish DNA elemen
Externí odkaz:
https://doaj.org/article/cfba4029f87447f8b2a0a47221a698d3
Publikováno v:
Molecules, Vol 25, Iss 6, p 1465 (2020)
Many natural coumarins and their chemically synthesized analogs and derivatives exert diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with the latter being of the utmost importance. The widely used warfarin,
Externí odkaz:
https://doaj.org/article/36e3070f703049ad91887e80eda066a3
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7248 (2009)
BACKGROUND:Reactions of vaccinia topoisomerase and the tyrosine site-specific recombinase Flp with methylphosphonate (MeP) substituted DNA substrates, have provided important insights into the electrostatic features of the strand cleavage and strand
Externí odkaz:
https://doaj.org/article/e354a9ee22fa4a4d9b86c6204f6e37eb
Autor:
Katarzyna Jastrzębska, Anna Maciaszek, Rafał Dolot, Agnieszka Tomaszewska-Antczak, Barbara Mikołajczyk, Piotr Guga
Publikováno v:
RSC Advances. 12:26815-26824
P-Diastereomers 1 were used in the stereoretentive synthesis of chimeric [PS]-{DNA:(2′-OMe)-RNA/RNA} oligomers and the stability of their duplexes did not correlate with the P-stereochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba29b0c99e062448e9803c64c5e61f0
https://doi.org/10.1039/d2ra04855h
https://doi.org/10.1039/d2ra04855h
Autor:
Róża Pawłowska, Piotr Guga
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca5a6b00eb164e4ee5b62098fcc7952
https://doi.org/10.1007/978-981-16-1313-5_51-1
https://doi.org/10.1007/978-981-16-1313-5_51-1
Publikováno v:
RSC Advances. 10:22370-22376
The results of CD measurements indicate that 2-4 LNA units distributed along 12 nt P-stereodefined phosphorothioate [RP-PS]-(DNA#LNA) chimeras impose a C3′-endo conformation on the 2′-deoxyribonucleosides. Under neutral and slightly acidic condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55672ec446e39422503c2d0e4fd51889
https://doi.org/10.1039/d0ra03934a
https://doi.org/10.1039/d0ra03934a
Autor:
Renata Kaczmarek, Ewa Radzikowska, Barbara Mikołajczyk, Dariusz Korczyński, Kraig A. Wheeler, Barbara Nawrot, Agnieszka Krakowiak, Tomasz Pawlak, Janina Baraniak, Piotr Guga
Publikováno v:
RSC Advances. 10:35185-35197
3′-N-(2-Thio-1,3,2-oxathiaphospholane) derivatives of 5′-O-DMT-3′-amino-2′,3′-dideoxy-ribonucleosides (NOTP-N), that bear a 4,4-unsubstituted, 4,4-dimethyl, or 4,4-pentamethylene substituted oxathiaphospholane ring, were synthesized. Within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240413e3490a54231fe489d32382148d
https://doi.org/10.1039/d0ra04987e
https://doi.org/10.1039/d0ra04987e
Publikováno v:
Organic & Biomolecular Chemistry. 17:4611-4620
3'-O-(2-Thio-4,4-pentamethylene-1,3,2-oxathiaphospholane) derivatives of 5'-O-DMT-N6-methyl-deoxyadenosine and 5'-O-DMT-N2,N2-dimethyl-O6-diphenylcarbamoyl-deoxyguanosine (OTP-NY, NY = DMT-m6dA or DMT-m,m2dGDPC) were synthesized, resolved onto pure P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92f78d6a3433205b35f0cb63fbe24c8
https://doi.org/10.1039/c8ob03112f
https://doi.org/10.1039/c8ob03112f
Publikováno v:
Molecules, Vol 25, Iss 6, p 1465 (2020)
Molecules
Molecules
Many natural coumarins and their chemically synthesized analogs and derivatives exert diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with the latter being of the utmost importance. The widely used warfarin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b136788c04138f6a1218b54a24d1baf4
https://www.mdpi.com/1420-3049/25/6/1465
https://www.mdpi.com/1420-3049/25/6/1465