Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Piotr F. J. Lipiński"'
Publikováno v:
Acta Poloniae Pharmaceutica, Vol 80, Iss 3, Pp 363-372 (2023)
We were interested in finding smallest possible ligands of the NK1 receptor (NK1R). Based on structural considerations and molecular docking (scoring) we selected six simple (low molecular weight, MW) 3,5-bistrifluoromethylbenzene derivatives and tes
Externí odkaz:
https://doaj.org/article/205f630e627f425e90e4da8ebf17322e
Autor:
Piotr F. J. Lipiński, Krzysztof Łyczko
Publikováno v:
Crystals, Vol 14, Iss 4, p 342 (2024)
The crystal structure of 3,5-bistrifluoromethylhydrocinnamic acid [systematic name: 3-[3,5-bis(trifluoromethyl)phenyl]propanoic acid], C11H8F6O2, has been determined and described. The structure was subject to the Hirshfeld surface-analysis and CE-B3
Externí odkaz:
https://doaj.org/article/b1751934e0c2465b85fe8d0bb8f7ae80
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2766 (2022)
One of the strategies in the search for safe and effective analgesic drugs is the design of multitarget analgesics. Such compounds are intended to have high affinity and activity at more than one molecular target involved in pain modulation. In the p
Externí odkaz:
https://doaj.org/article/881831b528724e4182cd7d4c33ac576d
Autor:
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 607 (2022)
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed. Following this trend, we continued our evaluation of aprepitant-bas
Externí odkaz:
https://doaj.org/article/07bfb308c5454d1f949bdbfa1fc3e68e
Autor:
Ewa Witkowska, Magda Godlewska, Jowita Osiejuk, Sandra Gątarz, Beata Wileńska, Katarzyna Kosińska, Joanna Starnowska-Sokół, Anna Piotrowska, Piotr F. J. Lipiński, Joanna Matalińska, Jolanta Dyniewicz, Paweł K. Halik, Ewa Gniazdowska, Barbara Przewlocka, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 674 (2022)
Based on the mechanism of neuropathic pain induction, a new type of bifunctional hybrid peptidomimetics was obtained for potential use in this type of pain. Hybrids consist of two types of pharmacophores that are connected by different types of linke
Externí odkaz:
https://doaj.org/article/5ac1bbccccea45039db1a0643d59e8af
Autor:
Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1214 (2022)
Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far, the radiopharmaceuticals used in this approach have been based on the endogenous agonist of N
Externí odkaz:
https://doaj.org/article/ffe5387d92fe4ac696320f656da8fa88
Autor:
Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska, Renata Mikołajczak
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Background The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carcinoma (MTC)), thus ma
Externí odkaz:
https://doaj.org/article/1c6b973729cd436ea3c17cb4c7ead88c
Autor:
Karol Wtorek, Piotr F. J. Lipiński, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Jarosław Sukiennik, Alicja Kluczyk, Anna Janecka
Publikováno v:
Molecules, Vol 27, Iss 1, p 151 (2021)
Our formerly described pentapeptide opioid analog Tyr-c[D-Lys-Phe-Phe-Asp]NH2 (designated RP-170), showing high affinity for the mu (MOR) and kappa (KOR) opioid receptors, was much more stable than endomorphine-2 (EM-2) in the rat brain homogenate an
Externí odkaz:
https://doaj.org/article/c146faeb9cb8454185fcfe4226b71699
Autor:
Piotr Garnuszek, Urszula Karczmarczyk, Michał Maurin, Arkadiusz Sikora, Jolanta Zaborniak, Justyna Pijarowska-Kruszyna, Antoni Jaroń, Monika Wyczółkowska, Wioletta Wojdowska, Dariusz Pawlak, Piotr F. J. Lipiński, Renata Mikołajczak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2731 (2021)
A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, an
Externí odkaz:
https://doaj.org/article/f6b7c2b5e462446b879629d438b04ecd
Autor:
Joanna Matalińska, Piotr F. J. Lipiński, Piotr Kosson, Katarzyna Kosińska, Aleksandra Misicka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7738 (2020)
AA3266 is a hybrid compound consisting of opioid receptor agonist and neurokinin-1 receptor (NK1R) antagonist pharmacophores. It was designed with the desire to have an analgesic molecule with improved properties and auxiliary anticancer activity. Pr
Externí odkaz:
https://doaj.org/article/a8938db87c144b71b71c01e25fc83891