Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Piotr Trzonkowski"'
Autor:
Joanna Chmiel, Mariusz Stasiak, Maria Skrzypkowska, Lucjan Samson, Piotr Łuczkiewicz, Piotr Trzonkowski
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36512- (2024)
Cellular therapies utilizing regulatory T cells (Tregs) have flourished in the autoimmunity space as a new pillar of medicine. These cells have shown a great promise in the treatment of such devastating conditions as type 1 diabetes mellitus (T1DM),
Externí odkaz:
https://doaj.org/article/719b97bd43d54ce881f54fde55f1c5b9
Autor:
Samikshya Santosh Nirmala, Kayani Kayani, Mateusz Gliwiński, Yueyuan Hu, Dorota Iwaszkiewicz-Grześ, Magdalena Piotrowska-Mieczkowska, Justyna Sakowska, Martyna Tomaszewicz, José Manuel Marín Morales, Kavitha Lakshmi, Natalia Maria Marek-Trzonkowska, Piotr Trzonkowski, Ye Htun Oo, Anke Fuchs
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
The initial idea of a distinct group of T-cells responsible for suppressing immune responses was first postulated half a century ago. However, it is only in the last three decades that we have identified what we now term regulatory T-cells (Tregs), a
Externí odkaz:
https://doaj.org/article/ad7a91b69f724da59a68e02fb2a5ce33
Autor:
Katarzyna Stefańska, Małgorzata Kurkowiak, Karolina Piekarska, Elżbieta Chruściel, Dorota Zamkowska, Joanna Jassem-Bobowicz, Przemysław Adamski, Renata Świątkowska-Stodulska, Anna Abacjew-Chmyłko, Katarzyna Leszczyńska, Maciej Zieliński, Krzysztof Preis, Hanna Zielińska, Bogusław Tymoniuk, Piotr Trzonkowski, Natalia Maria Marek-Trzonkowska
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPreeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis. However, t
Externí odkaz:
https://doaj.org/article/aebcbb608f8a41dc8dcbb63964485d75
Autor:
Juliusz Maksymilian Walczak, Dorota Iwaszkiewicz-Grześ, Michalina Ziomkowska, Magdalena Śliwka-Kaszyńska, Mateusz Daśko, Piotr Trzonkowski, Grzegorz Cholewiński
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2725-2741 (2022)
The group of 18 new amide derivatives of mycophenolic acid (MPA) and selected heterocyclic amines was synthesised as potential immunosuppressive agents functioning as inosine-5′-monophosphate dehydrogenase (IMPDH) uncompetitive inhibitors. The synt
Externí odkaz:
https://doaj.org/article/498254b97d354c888722d7f34919fc29
Autor:
Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka, Maria Bieniaszewska, Piotr Trzonkowski, Jacek M. Witkowski, Andrzej Hellmann, Katarzyna Ruckemann-Dziurdzińska, Jan M. Zaucha
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-10 (2022)
Abstract Background Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual’s immune response, both humoral and ce
Externí odkaz:
https://doaj.org/article/790677aa1e104f1082b8b2d2dbae3fa0
Autor:
Katarzyna Sznurkowska, Anna Borkowska, Agnieszka Zagierska, Magdalena Malanowska, Maciej Zieliński, Maciej Zagierski, Piotr Trzonkowski, Marcin Łosin, Agnieszka Szlagatys-Sidorkiewicz
Publikováno v:
Children, Vol 11, Iss 1, p 114 (2024)
Background: The massive resection of the small intestine leading to short bowel syndrome (SBS) deprives an organism of many immunocompetent cells concentrated in gut-associated lymphoid tissue, the largest immune organ in humans. We have aimed to acc
Externí odkaz:
https://doaj.org/article/20ad24474a204690985d1526ad44954c
Autor:
Karolina Piekarska, Zuzanna Urban-Wójciuk, Małgorzta Kurkowiak, Iwona Pelikant-Małecka, Adriana Schumacher, Justyna Sakowska, Jan Henryk Spodnik, Łukasz Arcimowicz, Hanna Zielińska, Bogusław Tymoniuk, Alicja Renkielska, Janusz Siebert, Ewa Słomińska, Piotr Trzonkowski, Ted Hupp, Natalia Maria Marek-Trzonkowska
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Regulatory T (Treg) cells and mesenchymal stem cells (MSCs) are both cell populations capable of immune tolerance induction. Here the authors show that the transfer of mitochondria from mesenchymal stem cells to allogeneic Treg cells in an HLA-depend
Externí odkaz:
https://doaj.org/article/62cdf80d4462409aafc5bd481b4188f6
Autor:
Martyna Tomaszewicz, Anna Ronowska, Maciej Zieliński, Agnieszka Jankowska-Kulawy, Piotr Trzonkowski
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD4+CD25highFoxP3+ regulatory T cells (Tregs) constitute a small but substantial fraction of lymphocytes in the immune system. Tregs control inflammation associated with infections but also when it is improperly directed against its tissues or cells.
Externí odkaz:
https://doaj.org/article/7ccddd1bdad4494c9e63531c65d6245c
Publikováno v:
Diagnostics, Vol 13, Iss 16, p 2668 (2023)
(1) Background: Multiple sclerosis (MS) is an auto-immune, chronic, neuroinflammatory, demyelinating disease that affects mainly young patients. This progressive inflammatory process causes the chronic loss of brain tissue and results in a deteriorat
Externí odkaz:
https://doaj.org/article/2788e5f30994427e83fe8afd809d1362
Autor:
Magdalena Piotrowska, Maciej Zieliński, Leszek Tylicki, Bogdan Biedunkiewicz, Alicja Kubanek, Zuzanna Ślizień, Karolina Polewska, Piotr Tylicki, Marta Muchlado, Justyna Sakowska, Marcin Renke, Adam Sudoł, Małgorzata Dąbrowska, Monika Lichodziejewska-Niemierko, Tomasz Smiatacz, Alicja Dębska-Ślizień, Piotr Trzonkowski
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccination against COVID-19 in patients with end-stage renal disease (ESRD) on replacement therapy and kidney transplant recipients (KTRs) is particularly important due to the high mortality rate. Here, we tested the local and systemic immunity to t
Externí odkaz:
https://doaj.org/article/e0a8124145e443249b7fc06582c7e168