Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Piotr, Wlaź"'
Autor:
Mateusz Pieróg, Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Małgorzata Samorek-Pieróg, Piotr Wlaź
Publikováno v:
Molecules, Vol 28, Iss 9, p 3810 (2023)
In contrast to the other components of the medium-chain triglycerides ketogenic diet (MCT KD), i.e., caprylic acid (CA8), a comprehensive evaluation of caproic (CA6) and lauric acids’ (CA12) properties in standard chemical and electrical seizure te
Externí odkaz:
https://doaj.org/article/865b190ff2b3427693b829fd7330aba0
Autor:
Urszula Doboszewska, Katarzyna Socała, Mateusz Pieróg, Dorota Nieoczym, Jan Sawicki, Adam Sajnóg, Bernadeta Szewczyk, Katarzyna Mlyniec, Ireneusz Sowa, Danuta Barałkiewicz, Piotr Wlaź
Publikováno v:
Cells, Vol 12, Iss 2, p 264 (2023)
The G-protein coupled receptor 39 (GPR39) is gaining increasing attention as a target for future drugs, yet there are gaps in the understanding of its pharmacology. Zinc is an endogenous agonist or an allosteric modulator, while TC-G 1008 is a synthe
Externí odkaz:
https://doaj.org/article/c36f91fdef304a0fb82be45243d9ce0b
Autor:
Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Marta Andres-Mach, Aleksandra Szewczyk, Gniewomir Latacz, Bartłomiej Szulczyk, Katarzyna Socała, Dorota Nieoczym, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
Cells, Vol 11, Iss 12, p 1862 (2022)
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, KA-104, that was previously discovered by our group. Consequently,
Externí odkaz:
https://doaj.org/article/9d34a801f4aa4feab4747cefcea04a31
Autor:
Urszula Doboszewska, Jan Sawicki, Adam Sajnóg, Aleksandra Szopa, Anna Serefko, Katarzyna Socała, Mateusz Pieróg, Dorota Nieoczym, Katarzyna Mlyniec, Gabriel Nowak, Danuta Barałkiewicz, Ireneusz Sowa, Piotr Wlaź
Publikováno v:
Cells, Vol 11, Iss 13, p 1987 (2022)
Several ligands have been proposed for the GPR39 receptor, including the element zinc. The relationship between GPR39 and magnesium homeostasis has not yet been examined, nor has such a relationship in the context of seizures/epilepsy. We used sample
Externí odkaz:
https://doaj.org/article/20242a421730498b8f200ea8c90c72d7
Publikováno v:
Molecules, Vol 26, Iss 16, p 4841 (2021)
Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects. Studies have revealed that EA may modulate seizure activity in che
Externí odkaz:
https://doaj.org/article/7228f5d331df4b79a82fedb328412274
Publikováno v:
Molecules, Vol 25, Iss 5, p 1204 (2020)
The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy. Salvinorin A is a potent plant-derived hallucinogen that acts as a highly selective κ-
Externí odkaz:
https://doaj.org/article/6f276fc1e93846e59d71a199f2e39af4
Autor:
Urszula Doboszewska, Katarzyna Socała, Mateusz Pieróg, Dorota Nieoczym, Jan Sawicki, Małgorzata Szafarz, Kinga Gawel, Anna Rafało-Ulińska, Adam Sajnóg, Elżbieta Wyska, Camila V. Esguerra, Bernadeta Szewczyk, Marzena Maćkowiak, Danuta Barałkiewicz, Katarzyna Mlyniec, Gabriel Nowak, Ireneusz Sowa, Piotr Wlaź
The pharmacological activation of the GPR39 receptor has been proposed as a novel strategy for treating seizures; however, this hypothesis has not been verified experimentally. TC-G 1008 is a small molecule agonist increasingly used to study GPR39 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dda598c23b230d670f39e7c602decfb
https://ruj.uj.edu.pl/xmlui/handle/item/311926
https://ruj.uj.edu.pl/xmlui/handle/item/311926
Autor:
Marta Andres-Mach, Mirosław Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Michał Abram, Marcin Jakubiec, Katarzyna Ciepiela, Katarzyna Socała, Piotr Wlaź, Gniewomir Latacz, Nadia Khan, Krzysztof Kaminski
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8302
Epilepsy is a neurological disorder involving a number of disease syndromes with a complex etiology. A properly matched antiseizure drug (ASD) gives remission in up to 70% of patients. Nevertheless, there is still a group of about 30% of patients suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53decfdbfce8268877ef7c4ee75db115
https://ruj.uj.edu.pl/xmlui/handle/item/311230
https://ruj.uj.edu.pl/xmlui/handle/item/311230
Autor:
Ewa Sajnaga, Katarzyna Socała, Agnieszka Kalwasińska, Piotr Wlaź, Adam Waśko, Monika Elżbieta Jach, Michał Tomczyk, Adrian Wiater
Publikováno v:
Food Chemistry. 417:135928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5a38ecb28af60399267b0b7079c61a8
https://doi.org/10.1016/j.foodchem.2023.135928
https://doi.org/10.1016/j.foodchem.2023.135928
Autor:
Małgorzata Szafarz, Agnieszka Zelek-Molik, Irena Nalepa, Dorota Nieoczym, Katarzyna Przejczowska-Pomierny, Piotr Wlaź, Elżbieta Wyska, Katarzyna Socała, Mateusz Pieróg
Publikováno v:
Psychopharmacology
Rationale Pterostilbene is the 3,5-dimethoxy derivative of resveratrol with numerous beneficial effects including neuroprotective properties. Experimental studies revealed its anticonvulsant action in the acute seizure tests. Objectives The purpose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82181542997ca4206a4ca46f4a216ffc
http://europepmc.org/articles/PMC8605980
http://europepmc.org/articles/PMC8605980