Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Piotr, Raubo"'
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Autor:
Linda Sundström, Susanna Myhre, Monika Sundqvist, Andrea Ahnmark, William McCoull, Piotr Raubo, Sam D Groombridge, Magnus Polla, Ann-Christin Nyström, Lisbeth Kristensson, Mats Någård, Maria Sörhede Winzell
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189060 (2017)
The mechanism behind the glucose lowering effect occurring after specific activation of GPR120 is not completely understood. In this study, a potent and selective GPR120 agonist was developed and its pharmacological properties were compared with the
Externí odkaz:
https://doaj.org/article/0ae7af91f78b4d848a82f18a857194db
Publikováno v:
Organic & Biomolecular Chemistry. 19:6274-6290
An efficient macrocyclisation approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodology allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of a significant num
Publikováno v:
Organicbiomolecular chemistry. 19(28)
An efficient macrocyclisation approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodology allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of a significant num
Autor:
Elisabetta Chiarparin, Amber Balazs, Martin J. Packer, Jeffrey W. Johannes, Nichola L. Davies, William McCoull, Graeme R. Robb, Piotr Raubo, Yu Dong, Alexander Hird, Rodrigo J. Carbajo, Michelle Lamb
Publikováno v:
Journal of Medicinal Chemistry. 62:9418-9437
The three-dimensional conformations adopted by a free ligand in solution impact bioactivity and physicochemical properties. Solution 1D NMR spectra inherently contain information on ligand conformational flexibility and three-dimensional shape, as we
Autor:
Piotr Raubo, Jonathan D. Beadle, Rebecca Notman, Eleanor S. Jayawant, Ina Wilkening, Michael Shipman, Ann M. Dixon
Peptide-based drugs combine advantages of larger biological therapeutics with those of small molecule drugs, but they generally display poor permeability and metabolic stability. Recently, we introduced a new type of peptide bond isostere, in which t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326bec79cda910845d6f2244132423fc
http://sro.sussex.ac.uk/id/eprint/108307/1/WRAP-macrocyclisation-small-peptides-enabled-oxetane-incorporation-Shipman-2018.pdf
http://sro.sussex.ac.uk/id/eprint/108307/1/WRAP-macrocyclisation-small-peptides-enabled-oxetane-incorporation-Shipman-2018.pdf
Autor:
Stefan Roesner, Leo K B Tam, Michael Shipman, Piotr Raubo, Guy J. Clarkson, Jonathan D. Beadle, Ina Wilkening
Publikováno v:
Organicbiomolecular chemistry. 18(28)
The synthesis and use of oxetane modified dipeptide building blocks in solution and solid-phase peptide synthesis (SPPS) is reported. The preparation of building blocks containing non-glycine residues at the N-terminus in a stereochemically controlle
Autor:
Andrew G. Jamieson, Jonathan D. Beadle, Laura McDougall, Dave J. Adams, Emily R. Draper, Piotr Raubo, Michael Shipman
Publikováno v:
Chemical Communications. 54:1793-1796
Low molecular weight gelators that are not easily degraded by enzymes have a range of potential applications. Here, we report new Fmoc-protected dipeptides in which the amide carbonyl group has been replaced by an oxetane ring. Remarkably one of thes
Autor:
Andrew G. Jamieson, Piotr Raubo, Michael Shipman, Astrid Knuhtsen, Alex Hoose, Jonathan D. Beadle
Publikováno v:
Organic Letters. 19:3303-3306
Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C=O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, the
Autor:
Nathan J. Patmore, Piotr Raubo, Joseph B. Sweeney, Ben Chappell, James J. Ryan, Lee Brown, Kirsty Adams, P. K. Tony Lo, James Birkett, Craig R. Rice, Anthony K. Ball, Duncan M. Gill
Publikováno v:
Nature Chemistry. 9:396-401
Heterocyclic architectures offer powerful creative possibilities to a range of chemistry end-users. This is particularly true of heterocycles containing a high proportion of sp3 -carbon atoms, which confer precise spatial definition upon chemical pro