Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Piotr, Lewczuk"'
Autor:
Katharina Luttenberger, Beat Baggenstos, Charbel Najem, Charles Sifri, Piotr Lewczuk, Anne Radegast, Simon Rosenbaum
Publikováno v:
Conflict and Health, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background Mental health and psychosocial support (MHPSS) is increasingly considered vital for addressing the needs of displaced communities. The mental health of young people in Lebanon, including members of the host community and refugees,
Externí odkaz:
https://doaj.org/article/012f63bc7d1c477686ce241cd5a227dc
Autor:
Miriam Rabl, Leonardo Zullo, Piotr Lewczuk, Johannes Kornhuber, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Francesco Bavato, Boris B. Quednow, Erich Seifritz, Armin von Gunten, Christopher Clark, Julius Popp
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Neuropsychiatric symptoms (NPS) are common in older people, may occur early in the development of dementia disorders, and have been associated with faster cognitive decline. Here, our objectives were to investigate whether plasma
Externí odkaz:
https://doaj.org/article/0f38378ecba046c399aaa3cc26c9200c
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603
Autor:
Joanna Kamińska, Marzena Tylicka, Kinga Sutkowska, Karolina Marta Gacuta, Magdalena Maria Sawicka, Ewa Kowalewska, Magdalena Ćwiklińska-Dworakowska, Mateusz Maciejczyk, Tomasz Łysoń, Johannes Kornhuber, Piotr Lewczuk, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms. The aim o
Externí odkaz:
https://doaj.org/article/1dd7656346334efdb9736f8275e8f91d
Autor:
Lara Blömeke, Fabian Rehn, Victoria Kraemer‐Schulien, Janine Kutzsche, Marlene Pils, Tuyen Bujnicki, Piotr Lewczuk, Johannes Kornhuber, Silka D. Freiesleben, Luisa‐Sophie Schneider, Lukas Preis, Josef Priller, Eike J. Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy‐Kluth, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Luca Kleineidam, Melina Stark, Matthias Schmid, Frank Jessen, Oliver Bannach, Dieter Willbold, Oliver Peters
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain
Externí odkaz:
https://doaj.org/article/4bb37b34bcf7452db948167c1f2af3cc
Autor:
Anna-Lena Haas, Pauline Olm, Janine Utz, Eva-Maria Siegmann, Philipp Spitzer, Anna Florvaag, Manuel Alexander Schmidt, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstein, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is indicated by a decrease in amyloid beta 42 (Aβ42) level or the Aβ42/Aβ40 ratio, and by increased levels of Tau with phosphorylated threonine at position 181 (pTau181) in cerebrospinal fluid (CSF) years bef
Externí odkaz:
https://doaj.org/article/a0515777f9ec40f49d049a47a82ea07a
Autor:
Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Julius Popp
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background To assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer’s disease (AD) pathology and predict clinical progression in a memory clinic setting. Methods
Externí odkaz:
https://doaj.org/article/ee7d4c72b4584c7f915d617ccb44b4f4
Autor:
Sami Ouanes, Christopher Clark, Jonas Richiardi, Bénédicte Maréchal, Piotr Lewczuk, Johannes Kornhuber, Clemens Kirschbaum, Julius Popp
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionElevated cortisol levels have been reported in Alzheimer’s disease (AD) and may accelerate the development of brain pathology and cognitive decline. Dehydroepiandrosterone sulfate (DHEAS) has anti-glucocorticoid effects and it may be in
Externí odkaz:
https://doaj.org/article/bf2221bc2fb3420a8fb738ebc5780130
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2019)
Abstract The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzhe
Externí odkaz:
https://doaj.org/article/5fbce95f4d9a4e5c8ee924ac54ac8ef6
Autor:
Timo Jan Oberstein, Janine Utz, Philipp Spitzer, Hans Wolfgang Klafki, Jens Wiltfang, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ starting with A
Externí odkaz:
https://doaj.org/article/a2e902a0eca44304b3e443ee4eb7ea2e