Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Piotr, Kosson"'
Autor:
Bartłomiej Fedorczyk, Patrycja Redkiewicz, Joanna Matalińska, Radosław Piast, Piotr Kosson, Rafał Wieczorek
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 190 (2024)
The interaction of Neuropilin-1 (NRP-1) with vascular endothelial growth factor (VEGF) has been shown to promote angiogenesis under physiological and pathological conditions. Angiogenesis around tumors is a major factor allowing for their growth and
Externí odkaz:
https://doaj.org/article/c1d5d33be17848c0b805b58450319216
Autor:
Jolanta Dyniewicz, Stefan Mordalski, Piotr F. J. Lipiński, Andrzej J. Bojarski, Piotr Kosson, Joanna Matalińska, Aleksandra Misicka
Publikováno v:
Pharmacological Reports. 75:465-473
Background G protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d99e1280c0f243fb7220d618a72ccb
https://doi.org/10.1007/s43440-023-00457-5
https://doi.org/10.1007/s43440-023-00457-5
Autor:
Edyta Kopera, Konrad Zdanowski, Karolina Uranowska, Piotr Kosson, Violetta Sączyńska, Katarzyna Florys, Bogusław Szewczyk
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
H1N1 influenza virus is still regarded as a serious pandemic threat. The most effective method of protection against influenza virus and the way to reduce the risk of epidemic or pandemic spread is vaccination. Influenza vaccine manufactured in a tra
Externí odkaz:
https://doaj.org/article/aee2a74d290b4dd28b882a3654518ed3
Autor:
Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, Aleksandra Misicka
Publikováno v:
Molecules, Vol 25, Iss 15, p 3429 (2020)
In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties. The considered fragments were ba
Externí odkaz:
https://doaj.org/article/39883173ef5c421bbb4bd786df89b925
Publikováno v:
Molecules, Vol 25, Iss 10, p 2461 (2020)
TAPP (H-Tyr-d-Ala-Phe-Phe-NH2) is a potent, µ-selective opioid ligand. In order to gain further insights into pharmacophoric features of this tetrapeptide, we have performed a β2-Homo-amino acid (β2hAA) scan of the TAPP sequence. To this aim, 10 n
Externí odkaz:
https://doaj.org/article/10f8a62eab5c47a396d412f103c1e9fd
Autor:
Patrycja Redkiewicz, Anna Stachyra, Róz∙a Sawicka, Katarzyna Bocian, Anna Góra-Sochacka, Piotr Kosson, Agnieszka Sirko
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Influenza is one of the most important illnesses in the modern world, causing great public health losses each year due to the lack of medication and broadly protective, long-lasting vaccines. The development of highly immunogenic and safe vaccines is
Externí odkaz:
https://doaj.org/article/79518f4bff9c4997b65996be9db8a36f
Autor:
Edyta Kopera, Agnieszka Katarzyna Macioła, Maria Anna Pietrzak, Piotr Kosson, Mariusz Czarnocki-Cieciura, Krzysztof Śmietanka, Zenon Minta
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Hemagglutinin glycoprotein (HA) is a principle influenza vaccine antigen. Recombinant HA-based vaccines become a potential alternative for traditional approach. Complexity and variation of HA N-glycosylation are considered as the important factors fo
Externí odkaz:
https://doaj.org/article/026a648e1f374a3799f41197d9639305
Autor:
Piotr F. J. Lipiński, Piotr Kosson, Joanna Matalińska, Piotr Roszkowski, Zbigniew Czarnocki, Małgorzata Jarończyk, Aleksandra Misicka, Jan Cz. Dobrowolski, Joanna Sadlej
Publikováno v:
Molecules, Vol 24, Iss 4, p 740 (2019)
Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using experimental and theoretical methods. Their binding to μOR was assessed with radioligand competitive binding assay. A uniform set of binding affinity data cont
Externí odkaz:
https://doaj.org/article/d0d92795855649f1a53b628ab3091545
Autor:
Jolanta Dyniewicz, Adriana Muchowska, Joanna Matalińska, Piotr F. J. Lipiński, Agnieszka Kotlarz, Piotr Kosson
Publikováno v:
International Journal of Peptide Research and Therapeutics. 26:2603-2617
In the present contribution we report design, synthesis and evaluation of receptor affinity, analgesic activity and cytotoxicity of a hybrid peptide, AWL3020. The peptide includes two pharmacophores, one of δ-opioid receptor (δOR) agonists and one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6f6a4a7c91cab0a703096a8a9a2d0ba
https://doi.org/10.1007/s10989-020-10051-5
https://doi.org/10.1007/s10989-020-10051-5
Autor:
Marta Bochyńska-Czyż, Marek Konop, Patrycja Redkiewicz, Joanna Matalińska, Hanna Kozłowska, Piotr Kosson
Publikováno v:
Open Medicine, Vol 15, Iss 1, Pp 249-253 (2020)
Open Medicine
Open Medicine
Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion. The best result in poros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5840a6e349e747d2eb975bf36a9e294c
https://doi.org/10.1515/med-2020-0031
https://doi.org/10.1515/med-2020-0031