Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Piotr, Bednarczyk"'
Autor:
Helmut Bischof, Selina Maier, Piotr Koprowski, Bogusz Kulawiak, Sandra Burgstaller, Joanna Jasińska, Kristian Serafimov, Monika Zochowska, Dominic Gross, Werner Schroth, Lucas Matt, David Arturo Juarez Lopez, Ying Zhang, Irina Bonzheim, Florian A Büttner, Falko Fend, Matthias Schwab, Andreas L Birkenfeld, Roland Malli, Michael Lämmerhofer, Piotr Bednarczyk, Adam Szewczyk, Robert Lukowski
Publikováno v:
eLife, Vol 12 (2024)
Alterations in the function of K+ channels such as the voltage- and Ca2+-activated K+ channel of large conductance (BKCa) reportedly promote breast cancer (BC) development and progression. Underlying molecular mechanisms remain, however, elusive. Her
Externí odkaz:
https://doaj.org/article/60f91b8d7664470fa1f56e117e4caef3
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-20 (2022)
Abstract Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). However, VDR-mediated transcriptional modulation does not fully explain vari
Externí odkaz:
https://doaj.org/article/75c5db1655544ff991224101ec85ace8
Publikováno v:
Membranes, Vol 13, Iss 9, p 763 (2023)
The cells of living organisms are surrounded by the biological membranes that form a barrier between the internal and external environment of the cells. Cell membranes serve as barriers and gatekeepers. They protect cells against the entry of undesir
Externí odkaz:
https://doaj.org/article/542bf39a26f244ceb35ac1e82001743d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The activation of mitochondrial large conductance calcium-activated potassium (mitoBKCa) channels increases cell survival during ischemia/reperfusion injury of cardiac cells. The basic biophysical and pharmacological properties of mitoBKCa c
Externí odkaz:
https://doaj.org/article/f49de50f2d0e446d8f6b5f2c3a700948
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010315 (2022)
The large conductance voltage- and Ca2+-activated K+ channels from the inner mitochondrial membrane (mitoBK) are modulated by a number of factors. Among them flavanones, including naringenin (Nar), arise as a promising group of mitoBK channel regulat
Externí odkaz:
https://doaj.org/article/cdea1e4f509d4160adc5982526c5854c
Autor:
Rafał P. Kampa, Lorenzo Flori, Aleksandra Sęk, Jacopo Spezzini, Simone Brogi, Adam Szewczyk, Vincenzo Calderone, Piotr Bednarczyk, Lara Testai
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1892 (2022)
Luteolin (LUT) is a well-known flavonoid that exhibits a number of beneficial properties. Among these, it shows cardioprotective effects, as confirmed by numerous studies. However, its effect on mitochondrial potassium channels, the activation of whi
Externí odkaz:
https://doaj.org/article/f4b9e1a05ead45e5b8be62f0e180bbf8
Autor:
Rafał P Kampa, Aleksandra Sęk, Piotr Bednarczyk, Adam Szewczyk, Vincenzo Calderone, Lara Testai
Publikováno v:
Journal of Pharmacy and Pharmacology. 75:466-481
Objectives Acute myocardial ischemia is one of the major causes of illness in western society. Reduced coronary blood supply leads to cell death and loss of cardiomyocyte population, resulting in serious and often irreversible consequences on myocard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216e6508ddf7bfda963da52a1cce3d49
https://doi.org/10.1093/jpp/rgac093
https://doi.org/10.1093/jpp/rgac093
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Process of inflammation and complex interactions between immune and cancer cells within tumor microenvironment are known to drive and shape the outcome of the neoplastic disease. Recent studies increasingly show that ion channels can be used as poten
Externí odkaz:
https://doaj.org/article/6eb2a5e66f0c4353b29cd78562aac890
Publikováno v:
Cells, Vol 10, Iss 6, p 1554 (2021)
Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover, mitochondria are involved in cardiac ischemia/reperfusion injury by opening the mitochondrial permeability transition pore which is the major cause of cell death. The
Externí odkaz:
https://doaj.org/article/347f8d767d4945c695a390c37194df3e
Publikováno v:
Molecules, Vol 26, Iss 11, p 3233 (2021)
Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane. Several hypotheses have b
Externí odkaz:
https://doaj.org/article/78d3141a59004be58d8f34d7012ce304