Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma.

Autor: Fernandez EG; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Mai WX; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Song K; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA., Bayley NA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Kim J; Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, Los Angeles, California, USA., Zhu H; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Pioso M; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Young P; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Andrasz CL; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Department of Human Genetics, University of California, Los Angeles, CA, 90095-7088, USA., Cadet D; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA., Liau LM; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Li G; Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, Los Angeles, California, USA., Yong WH; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Rodriguez FJ; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, 94305, USA., Souers AJ; AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL, 60064, USA., Li JJ; Department of Biostatistics, Jonathan and Karin Fielding School of Public Health, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, University of California, Los Angeles, CA, 90095-7088, USA.; Department of Computational Medicine, University of California, Los Angeles, CA, 90095-1766, USA.; Department of Statistics and Data Science, University of California, Los Angeles, CA, 90095-1554, USA., Graeber TG; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; UCLA Metabolomics Center, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, 90095, USA., Cloughesy TF; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nathanson DA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. dnathanson@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. dnathanson@mednet.ucla.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 21; Vol. 15 (1), pp. 10089. Date of Electronic Publication: 2024 Nov 21.

A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML.

Autor: Drenberg CD; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA. guttke.1@osu.edu.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA. guttke.1@osu.edu., Shelat A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Dang J; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Cotton A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Orwick SJ; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Li M; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Jeon JY; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Fu Q; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Buelow DR; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Pioso M; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Hu S; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Inaba H; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Ribeiro RC; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Rubnitz JE; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Gruber TA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Guy RK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40506, USA., Baker SD; Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.

Publikováno v: Nature communications [Nat Commun] 2019 May 16; Vol. 10 (1), pp. 2189. Date of Electronic Publication: 2019 May 16.

Venetoclax Combined with Intensive Chemotherapy: A New Hope for Refractory and/or Relapsed Acute Myeloid Leukemia?

Autor: Rahmé, Ramy^1,2 (AUTHOR) ramy.rahme@aphp.fr, Braun, Thorsten^1,2 (AUTHOR) thorsten.braun@aphp.fr

Publikováno v: Journal of Clinical Medicine. Jan2024, Vol. 13 Issue 2, p549. 16p.

Resistance of Leukemia Cells to 5-Azacytidine: Different Responses to the Same Induction Protocol.

Autor: Šimoničová, Kristína¹ (AUTHOR) kristina.simonicova@savba.sk, Janotka, Lubos^1,2 (AUTHOR) lubos.janotka@savba.sk, Kavcova, Helena¹ (AUTHOR) helena.kavcova@savba.sk, Sulova, Zdena¹ (AUTHOR) zdena.sulova@savba.sk, Messingerova, Lucia^1,3 (AUTHOR) lucia.messingerova@stuba.sk, Breier, Albert^1,3 (AUTHOR) lucia.messingerova@stuba.sk

Publikováno v: Cancers. Jun2023, Vol. 15 Issue 11, p3063. 23p.

Targeting cellular mitophagy as a strategy for human cancers.

Autor: Yuming Dong, Xue Zhang

Publikováno v: Frontiers in Cell & Developmental Biology; 2024, p1-8, 8p