Baricitinib therapy response in rheumatoid arthritis patients associates to STAT1 phosphorylation in monocytes

Autor: Gloria Tucci, Cristina Garufi, Ilenia Pacella, Marta Zagaglioni, Alessandra Pinzon Grimaldos, Fulvia Ceccarelli, Fabrizio Conti, Francesca Romana Spinelli, Silvia Piconese

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Baricitinib is a Janus kinase (JAK) 1 and 2 inhibitor approved for treating rheumatoid arthritis (RA). The JAK/STAT system is essential in the intracellular signaling of different cytokines and in the activation process of the monocyte lineage. This

Externí odkaz: https://doaj.org/article/caa3f6949ff2463799d10d5fd3f45ba9

The role of lipid metabolism in shaping the expansion and the function of regulatory T cells

Autor: Alessandra Pinzon Grimaldos, Simone Bini, Ilenia Pacella, Alessandra Rossi, Alessia Di Costanzo, Ilenia Minicocci, Laura D’Erasmo, Marcello Arca, Silvia Piconese

Publikováno v: Clin Exp Immunol

Metabolic inflammation, defined as a chronic low-grade inflammation, is implicated in numerous metabolic diseases. In recent years, the role of regulatory T cells (Tregs) as key controllers of metabolic inflammation has emerged, but our comprehension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b99dcfa8151accd2fe656a9c610bcc6
https://doi.org/10.1093/cei/uxab033

ANGPTL3 deficiency associates with the expansion of regulatory T cells with reduced lipid content

Autor: Alessandra Pinzon Grimaldos, Ilenia Pacella, Simone Bini, Gloria Tucci, Ilenia Cammarata, Alessia Di Costanzo, Ilenia Minicocci, Laura D'Erasmo, Marcello Arca, Silvia Piconese

Angiopoietin-like 3 (ANGPTL3) regulates lipid and glucose metabolism. Loss-of-function mutations in its gene, leading to ANGPTL3 deficiency, cause in humans the familial combined hypolipidemia type 2 (FHBL2) phenotype, characterized by very low conce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7829cdd8addfb041f3fdbb736e7cbad5
https://hdl.handle.net/11573/1659888

ANGPTL3 deficiency associates with expanded regulatory T cells with reduced lipid content

Autor: I. Pacella, Massimo Arcà, A. Di Costanzo, Simone Bini, Ilenia Minicocci, S. Piconese, Antonello Rossi, A. Pinzon Grimaldos, Laura D'Erasmo

Publikováno v: Atherosclerosis. 331:e12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6db9092ae1d66dd6f5d49ae40c2758e5
https://doi.org/10.1016/j.atherosclerosis.2021.06.040

Iron capture through CD71 drives perinatal and tumor-associated Treg expansion.

Autor: Pacella I; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pinzon Grimaldos A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Rossi A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Tucci G; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Zagaglioni M; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Potenza E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pinna V; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Rotella I; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Cammarata I; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Cancila V; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy., Belmonte B; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy., Tripodo C; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, Palermo, Italy., Pietropaolo G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Di Censo C; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Sciumè G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.; Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy., Licursi V; Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy, Sapienza University of Rome, Rome, Italy., Peruzzi G; Centre for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy., Antonucci Y; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Campello S; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Guerrieri F; Cancer Research Centre of Lyon (CRCL), UMR Inserm U1052/CNRS 5286, Lyon, France., Iebba V; Department of Medical, Surgical, and Health Sciences, University of Trieste, Trieste, Italy., Prota R; Department of Maternal and Child Health, Sapienza University of Rome, Rome, Italy., Di Chiara M; Department of Maternal and Child Health, Sapienza University of Rome, Rome, Italy., Terrin G; Department of Maternal and Child Health, Sapienza University of Rome, Rome, Italy., De Peppo V; Hepatobiliary and Pancreatic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Grazi GL; Hepatobiliary and Pancreatic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Barnaba V; Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.; Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Piconese S; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.; Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.; Unità di Neuroimmunologia, IRCCS Fondazione Santa Lucia, Rome, Italy.

Publikováno v: JCI insight [JCI Insight] 2024 Jul 02; Vol. 9 (15). Date of Electronic Publication: 2024 Jul 02.