ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation.

Autor: Junge M; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Liaukouskaya N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwarz N; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pinto-Espinoza C; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schaffrath AZ; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rissiek B; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rattay G; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mittrücker HW; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tomas NM; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Nicke A; Walther Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Haag F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meyer-Schwesinger C; Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wanner N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.

Origin, distribution, and function of three frequent coding polymorphisms in the gene for the human P2X7 ion channel.

Autor: Schäfer W; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Stähler T; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pinto Espinoza C; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Danquah W; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Knop JH; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rissiek B; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Haag F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2022 Nov 18; Vol. 13, pp. 1033135. Date of Electronic Publication: 2022 Nov 18 (Print Publication: 2022).

Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions.

Autor: Wilmes M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Pinto Espinoza C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Ludewig P; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Stabernack J; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Liesz A; Institute for Stroke and Dementia Research, University Medical Center, 813777, Munich, Germany.; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Nicke A; SyNergy Cluster for Systems Neurology, 81377, Munich, Germany., Gelderblom M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Gerloff C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Falzoni S; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Tolosa E; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Di Virgilio F; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Rissiek B; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Plesnilla N; Institute for Stroke and Dementia Research, University Medical Center, 813777, Munich, Germany., Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Magnus T; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. t.magnus@uke.de.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2022 Oct 12; Vol. 19 (1), pp. 256. Date of Electronic Publication: 2022 Oct 12.

A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo .

Autor: Gondé H; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France.; Rouen University Hospital, Department of Pharmacy, Rouen, France., Demeules M; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France., Hardet R; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France., Scarpitta A; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France., Junge M; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pinto-Espinoza C; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Varin R; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France.; Rouen University Hospital, Department of Pharmacy, Rouen, France., Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Boyer O; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France.; Rouen University Hospital, Department of Immunology and Biotherapy, Rouen, France., Adriouch S; Normandie University, UNIROUEN, INSERM U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative THERapies, Rouen, France.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Aug 19; Vol. 12, pp. 704408. Date of Electronic Publication: 2021 Aug 19 (Print Publication: 2021).

Novel biologics targeting the P2X7 ion channel.

Autor: Koch-Nolte F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: nolte@uke.de., Eichhoff A; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Normandie University, UNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies (PANTHER), 76000, Rouen, France., Pinto-Espinoza C; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwarz N; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schäfer T; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Menzel S; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Haag F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Demeules M; Normandie University, UNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies (PANTHER), 76000, Rouen, France., Gondé H; Normandie University, UNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies (PANTHER), 76000, Rouen, France., Adriouch S; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Normandie University, UNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular diseases and regenerative THERapies (PANTHER), 76000, Rouen, France. Electronic address: sahil.adriouch@univ-rouen.fr.

Publikováno v: Current opinion in pharmacology [Curr Opin Pharmacol] 2019 Aug; Vol. 47, pp. 110-118. Date of Electronic Publication: 2019 Apr 12.