Elevated rates of horizontal gene transfer in the industrialized human microbiome

Autor: Tommi Vatanen, Mathieu Groussin, Vanessa A. Juimo, Adwoa Agyei-Nkansah, Jeff Hooker, Jenni Lehtimäki, Lewis R. Roberts, Yaw Asante Awuku, Laure Ségurel, Amelie Plymoth, Mary Afihene, Roger E. Summons, Rihlat Said Mohamed, Alain Fezeu, Sophie Lafosse, Amoako Duah, Deborah Iqaluk, Mary Noel, Alain Froment, Ramnik J. Xavier, B. Jesse Shapiro, Audax Mabulla, Lasse Ruokolainen, Shadrack O. Asibey, Mathilde Poyet, Manuel Domínguez-Rodrigo, Sean M. Gibbons, Catherine Girard, Pinja P. Kettunen, Eric J. Alm, Shani Sigwazi, Katya Moniz, Charles A Onyekwere, Francis Ekwin Tabe, Kenneth Valles, Le Thanh Tu Nguyen, Sean M. Kearney, Ainara Sistiaga, Yvonne Ayerki Nartey

Publikováno v: Groussin, M, Poyet, M, Sistiaga, A, Kearney, S M, Moniz, K, Noel, M, Hooker, J, Gibbons, S M, Segurel, L, Froment, A, Mohamed, R S, Fezeu, A, Juimo, V A, Lafosse, S, Tabe, F E, Girard, C, Iqaluk, D, Nguyen, L T T, Shapiro, B J, Lehtimäki, J, Ruokolainen, L, Kettunen, P P, Vatanen, T, Sigwazi, S, Mabulla, A, Domínguez-Rodrigo, M, Nartey, Y A, Agyei-Nkansah, A, Duah, A, Awuku, Y A, Valles, K A, Asibey, S O, Afihene, M Y, Roberts, L R, Plymoth, A, Onyekwere, C A, Summons, R E, Xavier, R J & Alm, E J 2021, ' Elevated rates of horizontal gene transfer in the industrialized human microbiome ', Cell, vol. 184, no. 8, pp. 2053-2067.e18 . https://doi.org/10.1016/j.cell.2021.02.052
Elsevier
Cell
Cell, Elsevier, 2021, 184 (8), pp.2053-2067.e18. ⟨10.1016/j.cell.2021.02.052⟩

Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51491d434ae4f7bed377b0e8d992ebd1
https://pubmed.ncbi.nlm.nih.gov/33794144

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.

Autor: Wu YC; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland., Lehtonen Š; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland. sarka.lehtonen@uef.fi.; A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211, Kuopio, Finland. sarka.lehtonen@uef.fi., Trontti K; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland., Kauppinen R; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland., Kettunen P; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland., Leinonen V; NeuroCenter, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kuusisto J; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hovatta I; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Freude K; Department of Veterinary and Animal Sciences, University of Copenhagen, 1870, Frederiksberg, Denmark., Dhungana H; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland., Koistinaho J; Helsinki Institute of Life Science, University of Helsinki, 00014, Helsinki, Finland. jari.koistinaho@helsinki.fi.; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, 00014, Helsinki, Finland. jari.koistinaho@helsinki.fi., Rolova T; Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland. taisia.rolova@helsinki.fi.

Publikováno v: Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Sep 27; Vol. 21 (1), pp. 78. Date of Electronic Publication: 2024 Sep 27.

Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review.

Autor: Kettunen P; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Koistinaho J; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. jari.koistinaho@helsinki.fi., Rolova T; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2024 Jun 06; Vol. 21 (1), pp. 152. Date of Electronic Publication: 2024 Jun 06.

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice.

Autor: Jäntti H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.; Broad Institute, Cambridge, MA 02142, USA., Oksanen M; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Kettunen P; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland., Manta S; Centre de Recherches sur la Cognition Animale (CRCA), Université de Toulouse, CNRS, UPS, CEDEX 09, 31062 Toulouse, France.; Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France., Mouledous L; Centre de Recherches sur la Cognition Animale (CRCA), Université de Toulouse, CNRS, UPS, CEDEX 09, 31062 Toulouse, France.; Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France., Koivisto H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Ruuth J; Institute of Clinical Medicine, University of Eastern Finland, 70211 Kuopio, Finland., Trontti K; SleepWell Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.; Department of Psychology and Logopedics, University of Helsinki, 00014 Helsinki, Finland., Dhungana H; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland., Keuters M; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland., Weert I; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland., Koskuvi M; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland.; Department of Physiology and Pharmacology, Karolinska Institutet, 17165 Solna, Sweden., Hovatta I; SleepWell Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.; Department of Psychology and Logopedics, University of Helsinki, 00014 Helsinki, Finland., Linden AM; Department of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland., Rampon C; Centre de Recherches sur la Cognition Animale (CRCA), Université de Toulouse, CNRS, UPS, CEDEX 09, 31062 Toulouse, France.; Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 31062 Toulouse, France., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Tanila H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland., Koistinaho J; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland., Rolova T; Neuroscience Center, HILIFE, University of Helsinki, 00014 Helsinki, Finland.

Publikováno v: Cells [Cells] 2022 Dec 18; Vol. 11 (24). Date of Electronic Publication: 2022 Dec 18.