Phosphatidylinositol 3-kinase-δ up-regulates L-type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes.

Autor: Pinho, JF¹, Medeiros, MAA², Capettini, LSA¹, Rezende, BA¹, Campos, PP¹, Andrade, SP¹, Cortes, SF³, Cruz, JS², Lemos, VS¹, Pinho, J F¹ (AUTHOR), Medeiros, M A A (AUTHOR), Capettini, L S A (AUTHOR), Rezende, B A (AUTHOR), Campos, P P (AUTHOR), Andrade, S P (AUTHOR), Cortes, S F (AUTHOR), Cruz, J S (AUTHOR), Lemos, V S (AUTHOR)

Publikováno v: British Journal of Pharmacology. Dec2010, Vol. 161 Issue 7, p1458-1471. 14p.

Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment

Autor: Martino Bosco, Mauro M. Teixeira, Valeria Puntorieri, Emilio Hirsch, Fabricio O. Souto, V. Marco Ranieri, Virginia S. Lemos, Danielle G. Souza, Thomas Rückle, José C. Alves-Filho, Luisa Delsedime, Flávio A. Amaral, Barbara Assenzio, José Felippe Pinho, Fernando Q. Cunha, Caio T. Fagundes, Lorenzo Del Sorbo, Arthur S. Slutsky, E. L. Martin, Vito Fanelli

RATIONALE: Sepsis is a leading cause of death in the intensive care unit, characterized by a systemic inflammatory response (SIRS) and bacterial infection, which can often induce multiorgan damage and failure. Leukocyte recruitment, required to limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7e63739bb76f7205545b8aef378a25
http://hdl.handle.net/11585/663679

Augmentation index, a predictor of cardiovascular events, is increased in children and adolescents with primary nephrotic syndrome.

Autor: Alves C; Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil.; University Hospital of Medical Sciences, Belo Horizonte, MG, Brazil., Pinho JF; Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil., Dos Santos LM; Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil., Magalhães G; Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil., da Silva JM; University Hospital of Medical Sciences, Belo Horizonte, MG, Brazil., Fontes FL; Department of Pediatrics, Pediatric Nephrourology Unit, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Caligiorne SM; Mental Health Department, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Pinheiro S; Department of Pediatrics, Pediatric Nephrourology Unit, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Rodrigues-Machado MG; Medical Sciences Faculty of Minas Gerais, Post-Graduation Program in Health Sciences, Belo Horizonte, MG, Brazil. maria.machado@cienciasmedicasmg.edu.br.

Publikováno v: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2020 May; Vol. 35 (5), pp. 815-827. Date of Electronic Publication: 2019 Dec 16.

Vascular function in asthmatic children and adolescents.

Autor: Augusto LS; Faculdade Ciências Médicas-Minas Gerais, Pós-Graduação em Ciências da Saúde, 30130-110 Alameda Ezequiel Dias 275-Centro, Belo Horizonte, MG, Brazil., Silva GC; Departamento de Fisiologia e Biofísica da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Pinho JF; Faculdade Ciências Médicas-Minas Gerais, Pós-Graduação em Ciências da Saúde, 30130-110 Alameda Ezequiel Dias 275-Centro, Belo Horizonte, MG, Brazil., Aires RD; Departamento de Fisiologia e Biofísica da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Lemos VS; Departamento de Fisiologia e Biofísica da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Ramalho LF; Unidade de Referência de Saúde Saudade, Prefeitura de Belo Horizonte (URS Saudade- SUS BH), Belo Horizonte, MG, Brazil., Jentzsch NS; Departamento de Medicina, Faculdade Ciências Médicas-Minas Gerais, Belo Horizonte, MG, Brazil., Rodrigues-Machado MG; Faculdade Ciências Médicas-Minas Gerais, Pós-Graduação em Ciências da Saúde, 30130-110 Alameda Ezequiel Dias 275-Centro, Belo Horizonte, MG, Brazil. maria.machado@cienciasmedicasmg.edu.br.

Publikováno v: Respiratory research [Respir Res] 2017 Jan 17; Vol. 18 (1), pp. 17. Date of Electronic Publication: 2017 Jan 17.

Blocking the L-type Ca2+ channel (Cav 1.2) is the key mechanism for the vascular relaxing effect of Pterodon spp. and its isolated diterpene methyl-6α-acetoxy-7β-hydroxyvouacapan-17β-oate.

Autor: de Fátima Reis C; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., de Andrade DM; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., Junior Neves B; Laboratory for Molecular Modeling and Drug design, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., de Almeida Ribeiro Oliveira L; Laboratory of Natural Products Research, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., Pinho JF; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil., da Silva LP; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil., Dos Santos Cruz J; Laboratory of Excitable Membranes and Cardiovascular Biology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, UFMG, Brazil., Bara MT; Laboratory of Natural Products Research, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., Andrade CH; Laboratory for Molecular Modeling and Drug design, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil., Rocha ML; Laboratory of Cardiovascular Pharmacology, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO, Brazil. Electronic address: matheusroch@yahoo.com.br.

Publikováno v: Pharmacological research [Pharmacol Res] 2015 Oct; Vol. 100, pp. 242-9. Date of Electronic Publication: 2015 Aug 17.