Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Pingzheng, Zhou"'
Autor:
Xiaoyan Wu, Xin Yi, Boxin Zhao, Yuanxing Zhi, Ziwei Xu, Ying Cao, Xiong Cao, Jianxin Pang, Ken Kin Lam Yung, Shiqing Zhang, Shuwen Liu, Pingzheng Zhou
Publikováno v:
Pharmacological Research, Vol 198, Iss , Pp 107016- (2023)
The NLRP3 inflammasome is a supramolecular complex that is linked to sterile and pathogen-dependent inflammation, and its excessive activation underlies many diseases. Ion flux disturbance and cell volume regulation are both reported to mediate NLRP3
Externí odkaz:
https://doaj.org/article/d8d493bd9e1d4acd8d32e06aaa0de23a
Autor:
Ze’an Zhao, Yu Jiang, Lu Li, Yanyu Chen, Yongmei Li, Qunsheng Lan, Ting Wu, Cuiting Lin, Ying Cao, Kutty Selva Nandakumar, Pingzheng Zhou, Yuanxin Tian, Jianxin Pang
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 33421-33432 (2020)
Externí odkaz:
https://doaj.org/article/f36142f95466451aab36660a2fa61a10
Autor:
Xin Zhang, Xiulin Lin, Hui Luo, Yuanxing Zhi, Xin Yi, Xiaoyan Wu, Wendi Duan, Ying Cao, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106112- (2022)
Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In the present study, we fou
Externí odkaz:
https://doaj.org/article/9006914cad0e4935be71a309d68cb262
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases. Potassium efflux has been reported to be essential for NLRP3 inflammasom
Externí odkaz:
https://doaj.org/article/0030c12c946942378309b5719555ef33
Autor:
Fang Bai, Xiaoping Pi, Ping Li, Pingzheng Zhou, Huaiyu Yang, Xicheng Wang, Min Li, Zhaobing Gao, Hualiang Jiang
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Ion channels are important therapeutic targets, and their pharmacology is becoming increasingly important. However, knowledge of the mechanism of interaction of the activators and ion channels is still limited due to the complexity of the mechanisms.
Externí odkaz:
https://doaj.org/article/c7346be566b94751a8dafbb424f95ffd
Autor:
Yanyu Chen, Ying Cao, Yu Jiang, Yang Yang, Cuiting Lin, Lu Li, Jianxin Pang, Pingzheng Zhou, Jia-Yin Guo, Yongmei Li, Yuanxin Tian, Ting Wu, Zean Zhao, Qunsheng Lan
Publikováno v:
Acta Pharmacol Sin
Urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) are important targets for the development of uric acid-lowering drugs. We previously showed that the flexible linkers of URAT1 inhibitors could enhance their potency. In this study we desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b213413944822903e4e3390016c31c
https://doi.org/10.1038/s41401-021-00640-5
https://doi.org/10.1038/s41401-021-00640-5
Autor:
Yu Jiang, Pingzheng Zhou, Lu Li, Jianxin Pang, Qunsheng Lan, Yuanxin Tian, Kutty Selva Nandakumar, Ting Wu, Yanyu Chen, Ying Cao, Yongmei Li, Cuiting Lin, Zean Zhao
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 33421-33432 (2020)
ACS Omega
ACS Omega
Background: Human urate transporter 1 (hURAT1) is the most pivotal therapeutic target for treating hyperuricemia. However, the molecular interactions between uric acid and URAT1 are still unknown due to lack of structural details. Methods: In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d085117fef4c79e73cfe8d822f5d9f
https://doaj.org/article/f36142f95466451aab36660a2fa61a10
https://doaj.org/article/f36142f95466451aab36660a2fa61a10
Autor:
Xin, Zhang, Xiulin, Lin, Hui, Luo, Yuanxing, Zhi, Xin, Yi, Xiaoyan, Wu, Wendi, Duan, Ying, Cao, Jianxin, Pang, Shuwen, Liu, Pingzheng, Zhou
Publikováno v:
Pharmacological research. 177
Emerging data have demonstrated the critical roles of potassium efflux in the innate immune system. However, the role of potassium efflux in TLR3/4 activation and type I interferon (IFN) responses are not well elucidated. In the present study, we fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93f5fa1e95b13a068ebb39b18744e157
https://pubmed.ncbi.nlm.nih.gov/35370059
https://pubmed.ncbi.nlm.nih.gov/35370059
Autor:
Ting Wu, Ying Cao, Lijun Kang, Ziwei Xu, Xiaoyan Wu, Ken Kin Lam Yung, Jing Ren, Jin-yan Lv, Shiqing Zhang, Jianxin Pang, Xiong Cao, Yemei Liang, Qunsheng Lan, Pingzheng Zhou, Ka Li Lin
Publikováno v:
ACS Chemical Neuroscience. 10:2786-2793
K2P potassium channels stabilize the resting membrane potential in nearly all cells and have been implicated in several neuronal, cardiovascular, and immune diseases. DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3255c22c075400027f2bbaf15186bcf7
https://doi.org/10.1021/acschemneuro.9b00010
https://doi.org/10.1021/acschemneuro.9b00010
Autor:
Yuanxing, Zhi, Jin, Liu, Peihua, Kuang, Xin, Zhang, Ziwei, Xu, Yanshan, Chen, Xiuling, Lin, Xiaoyan, Wu, Pingzheng, Zhou, Jianjun, Chen
Publikováno v:
Biochemical Pharmacology. 199:114988
The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA and catalyzes the formation of 2'3'-cyclic-GMP-AMP (cGAMP), which in turn triggers interferon (IFN) production. Inappropriate activation of cGAS and production of cGAMP have been linked t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88855cd37da8f98632b01de28dec924
https://doi.org/10.1016/j.bcp.2022.114988
https://doi.org/10.1016/j.bcp.2022.114988