Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Pingyi, Xu"'
Autor:
Xingjian Li, Hanwen Zhu, Bik Tzu Huang, Xianting Li, Heesoo Kim, Haiyan Tan, Yuanxi Zhang, Insup Choi, Junmin Peng, Pingyi Xu, Ji Sun, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases, and their phosphorylation levels are elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the LRRK2-regulated RAB
Externí odkaz:
https://doaj.org/article/c6642f6ccf0b48588573ea27ac7e5236
Autor:
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Externí odkaz:
https://doaj.org/article/e15a20df902d4ceb826c7d921484d5b2
Autor:
Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng, Susma Gurung, Jiangang Huang, Jiayan Wu, Yijing Zhang, Arun Kumar Mahato, Mart Saarma, Mart Ustav, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Pingyi Xu, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeutics for obesity management. Here
Externí odkaz:
https://doaj.org/article/a29cc025e9664a529d8c924433238848
Autor:
Heng Huang, Lishan Lin, Tengteng Wu, Cheng Wu, Leping Zhou, Ge Li, Fengjuan Su, Fengyin Liang, Wenyuan Guo, Weineng Chen, Qiuhong Jiang, Yalun Guan, Xuejiao Li, Pingyi Xu, Yu Zhang, Wanli Smith, Zhong Pei
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Aquaporin-4 (AQP4) is essential for normal functioning of the brain’s glymphatic system. Impaired glymphatic function is associated with neuroinflammation. Recent clinical evidence suggests the involvement of glymphatic dysfunction in LRRK
Externí odkaz:
https://doaj.org/article/101cf4181b6947c9af12f66d347edaec
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/bf171edb5ad3469f9924f8933737d94f
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-5 (2023)
Abstract Background The glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 (LRRK2) genes are associated with the risk of sporadic Parkinson’s disease (PD). As an environmental factor, hypoxic insults may impair dopamine neurons in the substa
Externí odkaz:
https://doaj.org/article/3ce01f4b65814116b65a3eac5dbbd000
Autor:
Wenlong Zhang, Liuyan Ding, Huaqing Chen, Mengran Zhang, Runfang Ma, Shaohui Zheng, Junwei Gong, Zhiling Zhang, Huaxi Xu, Pingyi Xu, Yunlong Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-15 (2023)
Abstract Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk gene of autism, has been
Externí odkaz:
https://doaj.org/article/8837526eb4d64d928e375fc0f77843e4
Autor:
Lin Wang, Guihua Li, Chika F. Ezeana, Richard Ogunti, Mamta Puppala, Tiancheng He, Xiaohui Yu, Solomon S. Y. Wong, Zheng Yin, Aaron W. Roberts, Aryan Nezamabadi, Pingyi Xu, Adaani Frost, Robert E. Jackson, Stephen T. C. Wong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Healthcare regulatory agencies have mandated a reduction in 30-day hospital readmission rates and have targeted COPD as a major contributor to 30-day readmissions. We aimed to develop and validate a simple tool deploying an artificial neural
Externí odkaz:
https://doaj.org/article/55d2ff9979064e1482b81e7600ef8c13
Autor:
Lin Lu, Hengxu Mao, Miaomiao Zhou, Yuwan Lin, Wei Dai, Jiewen Qiu, Yousheng Xiao, Mingshu Mo, Xiaoqin Zhu, Zhuohua Wu, Zhong Pei, Wenyuan Guo, Pingyi Xu, Xiang Chen, Yuanyuan Ji
Publikováno v:
Chinese Medical Journal, Vol 135, Iss 13, Pp 1588-1596 (2022)
Background:. Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's dementia. Mitochondrial dysfunction is involved in the pathology of PD. Coiled-coil-helix-coiled-coil-helix domain-containing 2 (CHCHD2) was i
Externí odkaz:
https://doaj.org/article/73955be826874c989ba386e63d922a43
Autor:
Jiewen Qiu, Guoyou Peng, Yuting Tang, Shiyin Li, Zengfu Liu, Jiayun Zheng, Yunxin Wang, Hanqun Liu, Lijian Wei, Yilin Su, Yuwan Lin, Wei Dai, Zhiling Zhang, Xiang Chen, Liuyan Ding, Wenyuan Guo, Xiaoqin Zhu, Pingyi Xu, Mingshu Mo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disease with characteristic pathological abnormalities, including the loss of dopaminergic (DA) neurons, a dopamine-depleted striatum, and microglial activation. Lipid accumulati
Externí odkaz:
https://doaj.org/article/8fe1878752684e5a9a3762588b8bbd3d