Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Pingwah Tang"'
Publikováno v:
European Journal of Medicinal Chemistry. 157:1526-1540
A series of new carbamodithioates compounds has been successfully synthesized. All the carbamodithioate derivatives of SFE and SFA with benzenethiols (substituted or unsubstituted) exhibited, in general, higher percentages of inhibition than their pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521cdf4a56bc366c0e25da6af64d2d1e
https://doi.org/10.1016/j.ejmech.2018.07.038
https://doi.org/10.1016/j.ejmech.2018.07.038
Publikováno v:
Current Organic Synthesis. 15:256-266
Aim and Objective: α-Arylglycines belong to an important class of non-proteinogenic amino acids. Petasis 3-component, one-pot reaction lends itself to be suitable for the synthesis of α-Arylglycines. Because of the low reactivity, Petasis reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1df1899065118a6e609546ddc64cdcc
https://doi.org/10.2174/1570179414666170821115834
https://doi.org/10.2174/1570179414666170821115834
Publikováno v:
MedChemComm. 9:344-352
Histone deacetylases (HDACs) play a key role not only in gene expression but also in DNA repair. Herein, we report the rational design and characterization of a compound named chlordinaline containing nitrogen mustard and 2-aminobenzamide moieties as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66ff4751a47ea55a53dc1263a6d4457
https://doi.org/10.1039/c7md00476a
https://doi.org/10.1039/c7md00476a
Publikováno v:
European Journal of Medicinal Chemistry. 143:320-333
A novel series of 2-aminobenzamides with dithiocarbamate as cap group were designed and synthesized as histone deacetylase (HDAC) inhibitors. Most newly synthesized compounds displayed potent antiproliferative activity against diverse human tumor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b77e671c2a0d6aed1cfc1c468eb7da5
https://doi.org/10.1016/j.ejmech.2017.08.041
https://doi.org/10.1016/j.ejmech.2017.08.041
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4415-4420
Histone deacetylases (HDACs) play a pivotal role not only in gene expression but also in DNA repair. Herein, we report the successful design, synthesis and evaluation of a chlorambucil derivative named vorambucil with a hydroxamic acid tail as a DNA/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f199f823da49e57c3ca387d56d6a61c2
https://doi.org/10.1016/j.bmcl.2017.08.011
https://doi.org/10.1016/j.bmcl.2017.08.011
Autor:
Fan Yun, Yao Yue, Pingwah Tang, Xinying Wu, Qipeng Yuan, Rui Xie, Liu Xia, Chunhui Cheng, Chen Guangyao
Publikováno v:
European Journal of Medicinal Chemistry. 134:1-12
Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, we designed and synthesized two series of hydroxamates and 2-aminobenzam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b227866ea08fd27e16175e102e0d2d
https://doi.org/10.1016/j.ejmech.2017.03.038
https://doi.org/10.1016/j.ejmech.2017.03.038
Publikováno v:
Synthesis. 49:1583-1596
A novel and facile boric acid catalyzed direct amidation between amino-azaarene compounds and carboxylic acids has been developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::097071dd5ce7ef5bcaa2b1c0023662e7
https://doi.org/10.1055/s-0036-1588126
https://doi.org/10.1055/s-0036-1588126
Autor:
Chunhui Cheng, Ming Yang, Rui Xie, Liu Xia, Qipeng Yuan, Xinying Wu, Jinghua Shi, Fan Yun, Pingwah Tang
Publikováno v:
Medicinal Chemistry. 12:767-774
A novel, green, and atom-economical boric acid catalyzed direct amidation without the use of any coupling agents for the preparation of suberoylanilide hydroxamic acid (SAHA) and SAHA-based inhibitors targeting anti-proliferation of cancer cells is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66acbc6f336abc7088740762faf08d14
https://doi.org/10.2174/1573406412666160404125551
https://doi.org/10.2174/1573406412666160404125551
Autor:
Chunhui Cheng, Qipeng Yuan, Rui Xie, Jingxuan Li, Jing Zhang, Chen Guangyao, Pingwah Tang, Fan Yun
Publikováno v:
Tetrahedron Letters. 57:3916-3919
We have discovered that trifluoroacetic acid is an efficient catalyst to accelerate the Petasis three-component, one-pot process, reducing reaction times, and offering good to excellent yields. A series of azaarene-derived glycines have been successf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aefd2e00bbae6c76de9cf8de57aeb7d
https://doi.org/10.1016/j.tetlet.2016.07.054
https://doi.org/10.1016/j.tetlet.2016.07.054
Publikováno v:
Food Chemistry. 199:301-306
Sulforaphene, a natural compound, has been investigated as a potential anticancer agent. However, the stability of sulforaphene, in various solvents, and its degradation pathway have not been appropriately reported. This instability impairs the prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b39fc643aeeeea08f2a02c8af354b8
https://doi.org/10.1016/j.foodchem.2015.12.018
https://doi.org/10.1016/j.foodchem.2015.12.018