Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Pinglong Xu"'
Autor:
An Shao, Lulu Jin, Yanni Ge, Ziqiang Ye, Mingyu Xu, Yifan Zhou, Yingyu Li, Linyan Wang, Pinglong Xu, Kai Jin, Zhengwei Mao, Juan Ye
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 392-405 (2024)
Retinal neovascularization (RNV), a typical pathological manifestation involved in most neovascular diseases, causes retinal detachment, vision loss, and ultimately irreversible blindness. Repeated intravitreal injections of anti-VEGF drugs were deve
Externí odkaz:
https://doaj.org/article/45b5147555d34f59bc7d8743357b48d0
Autor:
Xinran Li, Xiao Li, Cong Xiang, Jin Cao, Jiansheng Guo, Shilei Zhu, Jingyi Tan, Lijing Wang, Chun Gao, Shengduo Liu, Lifeng Zhao, Bo Yuan, Pinglong Xu, Bing Yang, Dali Li, Bin Zhao, Xin-Hua Feng
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114728- (2024)
Summary: Pyroptosis, a pro-inflammatory form of programmed cell death, is crucial for host defense against pathogens and danger signals. Proteolytic cleavage of gasdermin proteins B–E (GSDMB–GSDME) is well established as a trigger for pyroptosis,
Externí odkaz:
https://doaj.org/article/ab33ba34789240a5ae1368358e27c082
Autor:
Xinran Li, Cong Xiang, Shilei Zhu, Jiansheng Guo, Chang Liu, Ailian Wang, Jin Cao, Yan Lu, Dante Neculai, Pinglong Xu, Xin-Hua Feng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lysosomal Storage Disorders (LSDs), which share common phenotypes, including enlarged lysosomes and defective lysosomal storage, are caused by mutations in lysosome-related genes. Although gene therapies and enzyme replacement therapies have
Externí odkaz:
https://doaj.org/article/a1738fc17a174dfaa7178f18c93ad607
Autor:
Yingfeng Tu, Qin Yang, Min Tang, Li Gao, Yuanhao Wang, Jiuqiang Wang, Zhe Liu, Xiaoyu Li, Lejiao Mao, Rui zhen Jia, Yuan Wang, Tie-shan Tang, Pinglong Xu, Yan Liu, Lunzhi Dai, Da Jia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Liver kinase B1 (LKB1), an evolutionarily conserved serine/threonine kinase, is a master regulator of the AMPK subfamily and controls cellular events such as polarity, proliferation, and energy homeostasis. Functions and mechanisms of the LK
Externí odkaz:
https://doaj.org/article/1003e6c99c3f49bfa3199ad69e3c8016
Autor:
Chenlei Zheng, Junli Wang, Yu Zhou, Yi Duan, Rujia Zheng, Yuting Xie, Xiaobao Wei, Jiangchao Wu, Hang Shen, Mao Ye, Bo Kong, Yun-Hua Liu, Pinglong Xu, Qi Zhang, Tingbo Liang
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114088- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) features an immunosuppressive tumor microenvironment (TME) that resists immunotherapy. Tumor-associated macrophages, abundant in the TME, modulate T cell responses. Bone marrow stromal antigen 2-positi
Externí odkaz:
https://doaj.org/article/04b5de10b021431a8d3ab9b118ee35d3
Autor:
Ning Wang, Yu Jiang, Mengjie Li, Haofei Wang, Jie Pan, Yang Tang, Shaofang Xie, Yunyang Xu, Xu Li, Xuefei Zhou, Pinglong Xu, Wenlong Lin, Xiaojian Wang
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract Immunotherapy targeting PD‐L1 is still ineffective for a wide variety of tumors with high unpredictability. Deploying combined immunotherapy with alternative targeting is practical to overcome this therapeutic resistance. Here, the deficie
Externí odkaz:
https://doaj.org/article/8d4b8139261d460b99d832f6db8ea24a
Autor:
Lijing Wang, Shuchen Gu, Fenfang Chen, Yi Yu, Jin Cao, Xinran Li, Chun Gao, Yanzhen Chen, Shuchong Yuan, Xia Liu, Jun Qin, Bin Zhao, Pinglong Xu, Tingbo Liang, Hongyan Tong, Xia Lin, Xin-Hua Feng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers, best exemplified by loss-of-function mutations in genes encoding components of the TGF-β signaling pathway in colorectal and pancreatic cancers
Externí odkaz:
https://doaj.org/article/16bd1f9ced0a45acbc2dd8fe20b1fd71
Publikováno v:
Cancer Biology & Medicine, Vol 20, Iss 2, Pp 93-97 (2023)
Externí odkaz:
https://doaj.org/article/5dda9148812d448b9d63c0fffeb2de0d
Autor:
Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li, Wenqi Wang, Ruhong Zhou, Tianhua Zhou, Aifu Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cancer cells exploit immune checkpoint pathways, such as PD-1/PD-L1, to evade elimination by the immune system. Here, the authors demonstrate that TMUB1 regulates post-translational modifications of PD-L1 and that targeting the TMUB1/PD-L1 interactio
Externí odkaz:
https://doaj.org/article/5c9afa68434c4156b9404910dc8406e1
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mitochondria are versatile organelles and essential components of numerous biological processes such as energy metabolism, signal transduction, and cell fate determination. In recent years, their critical roles in innate immunity have come to the for
Externí odkaz:
https://doaj.org/article/322eb08f28f543978da18349203dd5e6