Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Pingfu Feng"'
Objective To determine the effect of Bmal1 knockdown (KD) on sleep, activity, immobility, hypothalamic levels of orexin, corticotrophin-releasing hormone (CRH), and GABAergic glutamate decarboxylase (GAD). Methods We used Bmal1 siRNA, or control siRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040c97c63ebd91bf19ac51b1fb65c78f
https://europepmc.org/articles/PMC6490068/
https://europepmc.org/articles/PMC6490068/
Publikováno v:
Journal of Psychiatric Research. 69:110-119
Brain-derived neurotrophic factor (BDNF) binds to Tropomyosin-receptor-kinase B (TrkB) receptors that regulate synaptic strength and plasticity in the mammalian nervous system. 7,8-Dihydroxyflavone (DHF) is a recently identified small molecule Trk B
Publikováno v:
Journal of Psychiatric Research. 59:140-147
Decreased orexin level has been well demonstrated in patients suffering from narcolepsy, depression accompanied with suicide attempt; obstructive sleep apnea and comorbidity were also demonstrated in these diseases. As C57BL/6J (B6) mice are more “
Autor:
Vincent M. Monnier, Yufen Hu, Hyoung Gon Lee, Weiyi Feng, Yuxuan Fan, Pingfu Feng, Xingjun Fan, Mariana G. Rosca
Publikováno v:
Human molecular genetics. 26(7)
Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular glutathione (GSH) synthesis. The GSH concentration and GCL activity are declining with age in the central nervous system (CNS), and is accompanied by elevated reactive
Publikováno v:
Psychiatry research. 243
Neuroligins (NLGNs) regulate synaptic excitability, neuronal signaling and sleep. We hypothesize that alteration of NLGNs is involved in the pathology of depression and tested the hypothesis in a model of depression using Wistar Kyoto (WKy) rat and i
Publikováno v:
Sleep and Breathing. 16:1181-1191
Neonatal treatment with clomipramine (CLI) has been shown to have reliable behavioral and biological changes that mimic major symptomatic and biochemical changes found in depression. This paper further explores a common feature of depression, the com
Publikováno v:
ILAR Journal. 50:248-261
Sleep-disordered breathing comprises alterations in respiratory rate, rhythm, and depth that present during sleep and may or may not be recognizable in breathing during wakefulness. Primary disorders include repetitive apneas, near apneas (hypopneas)
Publikováno v:
Behavioural Brain Research. 182:95-102
Sleep/wake regulation is quite different during the neonatal and adult periods. Although cholinergic neurons have been recognized to be the major source of rapid eye movement (REM) sleep regulation in adulthood, their effect on neonatal REM sleep rem
Publikováno v:
Brain Research. 1154:163-172
Maternal deprivation (MD) is a neonatal stressor that leads to behavioral and molecular manifestations of chronic stress in adulthood. Recent evidence has suggested that stress may impact wake regulation through corticotropin-releasing hormone (CRH)
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 100:356-359
Although it has been proposed that exposure to lithium up-regulates brain-derived neurotrophic factor (BDNF), B-cell leukaemia/lymphoma 2 protein (Bcl-2) and cyclic AMP-response element-binding protein (CREB), and these molecules are involved in the