Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pingdewinde N, Sam"'
Autor:
Elizabeth Calzada, Erica Avery, Pingdewinde N. Sam, Arnab Modak, Chunyan Wang, J. Michael McCaffery, Xianlin Han, Nathan N. Alder, Steven M. Claypool
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Phosphatidylethanolamine (PE) is synthesized by four separate pathways, although surprisingly, perturbing mitochondrial PE synthesis compromises mitochondrial function. Here, the authors show that mitochondrial PE synthesis is required for Complex II
Externí odkaz:
https://doaj.org/article/ca5c4b849f3d4bd9ac4625fe961b2b19
Autor:
Pingdewinde N. Sam, Elizabeth Calzada, Michelle Grace Acoba, Tian Zhao, Yasunori Watanabe, Anahita Nejatfard, Jonathan C. Trinidad, Timothy E. Shutt, Sonya E. Neal, Steven M. Claypool
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102196- (2021)
Summary: Phosphatidylethanolamine (PE) made in mitochondria has long been recognized as an important precursor for phosphatidylcholine production that occurs in the endoplasmic reticulum (ER). Recently, the strict mitochondrial localization of the en
Externí odkaz:
https://doaj.org/article/5673c62c20164817be88580fb0fa27b1
Publikováno v:
ACS Chem Biol
Synthesis and regulation of lipid levels and identities is critical for a wide variety of cellular functions, including structural and morphological properties of organelles, energy storage, signaling, and stability and function of membrane proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa70fccb8c5d935e8237fd628296f88b
https://doi.org/10.1021/acschembio.9b00695
https://doi.org/10.1021/acschembio.9b00695
Autor:
J. Michael McCaffery, Steven M. Claypool, Arnab Modak, Chunyan Wang, Elizabeth Calzada, Erica Avery, Pingdewinde N. Sam, Xianlin Han, Nathan N. Alder
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Of the four separate PE biosynthetic pathways in eukaryotes, one occurs in the mitochondrial inner membrane (IM) and is executed by phosphatidylserine decarboxylase (Psd1). Deletion of Psd1 is lethal in mice and compromises mitochondrial function. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92c4d0e750afafa67e8a4f7d8d5facc
https://doaj.org/article/ca5c4b849f3d4bd9ac4625fe961b2b19
https://doaj.org/article/ca5c4b849f3d4bd9ac4625fe961b2b19
Autor:
Bridgette D Semple, Linda J Noble-Haeusslein, Yong Jun Kwon, Pingdewinde N Sam, A Matt Gibson, Sarah Grissom, Sienna Brown, Zahra Adahman, Christopher A Hollingsworth, Alexander Kwakye, Kayleen Gimlin, Elisabeth A Wilde, Gerri Hanten, Harvey S Levin, A Katrin Schenk
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103386 (2014)
Despite the life-long implications of social and communication dysfunction after pediatric traumatic brain injury, there is a poor understanding of these deficits in terms of their developmental trajectory and underlying mechanisms. In a well-charact
Externí odkaz:
https://doaj.org/article/c16fcecfa2c94e0998149ac92e4ded95
Autor:
Yasunori Watanabe, Timothy E. Shutt, Sonya E. Neal, Pingdewinde N. Sam, Anahita Nejatfard, Tian Zhao, Jonathan C. Trinidad, Steven M. Claypool, Elizabeth Calzada, Michelle Grace Acoba
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102196-(2021)
iScience
iScience
Summary Phosphatidylethanolamine (PE) made in mitochondria has long been recognized as an important precursor for phosphatidylcholine production that occurs in the endoplasmic reticulum (ER). Recently, the strict mitochondrial localization of the enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d815f955a613660962a1e79aaf1f194c
http://www.sciencedirect.com/science/article/pii/S2589004221001644
http://www.sciencedirect.com/science/article/pii/S2589004221001644
Autor:
Steven M. Claypool, Sonya E. Neal, Anahita Nejatfard, Michelle Grace Acoba, Elizabeth Calzada, Tian Zhao, Timothy E. Shutt, Pingdewinde N. Sam, Jonathan C. Trinidad, Yasunori Watanabe
SUMMARYPhosphatidylethanolamine made in mitochondria has long been recognized as an important precursor for phosphatidylcholine production that occurs in the endoplasmic reticulum (ER). Recently, the strict mitochondrial localization of the enzyme th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7803c54e0c468bfc671f6a9036dfd636
https://doi.org/10.1101/2020.12.10.416495
https://doi.org/10.1101/2020.12.10.416495
Autor:
Markus S. Spurlock, Deborah A. Shear, Stephanie W. Lee, Aminul I. Ahmed, Pingdewinde N. Sam, Karl Johe, Michael P. Hefferan, Frank C. Tortella, Karla N. Rivera, Ross Bullock, Shyam Gajavelli, Shoji Yokobori, Thomas G. Hazel
Publikováno v:
Journal of Neurotrauma. 34:1981-1995
Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread perilesional neurodegeneration, similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01f23c3703d2df7a78e8cbbb85ab377
https://doi.org/10.1089/neu.2016.4602
https://doi.org/10.1089/neu.2016.4602
PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes
Autor:
Tian Zhao, Caitlin Goedhart, Jillian S. Parboosingh, Jean E. Vance, Timothy E. Shutt, David S. Sinasac, Ryan E. Lamont, Adam J Cornish, A. Micheil Innes, Pingdewinde N. Sam, Steven M. Claypool, Rasha Sabouny, Susanne Lingrell, Francois P. Bernier
Publikováno v:
Life Science Alliance
This work demonstrates that pathogenic variants in PISD cause mitochondrial disease and suggests a novel mechanistic link whereby impaired lipid content in the inner mitochondrial membrane alters the activity of inner mitochondrial membrane proteases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1d342a9f16fc3f311f436a1ce6a477
http://europepmc.org/articles/PMC6412922
http://europepmc.org/articles/PMC6412922
PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes
Autor:
Jean E. Vance, Tian Zhao, Timothy E. Shutt, A. Micheil Innes, Caitlin Goedhart, Ryan E. Lamont, Pingdewinde N. Sam, Jillian S. Parboosingh, Adam J Cornish, David S. Sinasac, Steven M. Claypool, Susanne Lingrell, Francois P. Bernier
Exome sequencing of two sisters with congenital cataracts, short stature and white matter changes identified compound heterozygous variants in thePISDgene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine (PS) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23381be23b2612376a5e3d22e17e67eb