Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Pingda Ren"'
Autor:
Xiaogen Yang, Zhiwen Li, Wenwen Xu, Guanming Zhu, Xiantong Feng, Jun Zhang, Hongbin Zhao, Yuyin Chen, Jianshe Kong, Wanping Mai, Lian-Sheng Li, Daniel J. Pippel, Pingda Ren, Xiaohu Deng
Publikováno v:
Organic Process Research & Development. 27:206-216
Autor:
Brett D. Allison, Xiaohu Deng, Lian-Sheng Li, Jimmy Liang, Neelakandha S. Mani, Pingda Ren, Zachary S. Sales
Publikováno v:
Organic Process Research & Development. 26:2926-2936
Autor:
Yi Liu, Pingda Ren, Anjali Babbar, Sarah J. Firdaus, Jeffrey H. Chen, Tess Ely, Jun Feng, Jeff M. Kucharski, Yuching Chen, Linda V. Kessler, Ulf Peters, Rasmus Hansen, Lian-Sheng Li, Matthew R. Janes, Matthew P. Patricelli
Supplementary Table 1. Biochemical and Cell engagement SAR. Supplementary Table 2. Data collection and refinement statistics (Molecular replacement). Supplementary Table 3. Selectivity of ARS-853 across KRAS isoforms and GTP vs. GDP states. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4c1da5f413c618429e4a216ba9b29
https://doi.org/10.1158/2159-8290.22531619
https://doi.org/10.1158/2159-8290.22531619
Publikováno v:
Organic Process Research & Development. 25:1664-1669
Publikováno v:
Organic Process Research & Development. 25:1637-1647
Autor:
Yi Wang, Yinwei Xie, Pingda Ren, Xiaohu Deng, Wanping Mai, Huazhen Chen, Hongbing Wu, Yuanyang Zhang
Publikováno v:
AAPS PharmSciTech. 22
Formulation development of KO-947-K mesylate injectable drug products was described. Solution formulations were initially attempted, and key parameters such as drug concentration, buffer, pH, complexing agent, and tonicity modifying agent were carefu
Autor:
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M. Linhares, Dong Chen, Gloria Jih, Eric Perkey, Huang Huang, Miao He, Bo Wen, Yi Wang, Ke Yu, Stanley Chun-Wei Lee, Gwenn Danet-Desnoyers, Winifred Trotman, Malathi Kandarpa, Anitria Cotton, Omar Abdel-Wahab, Hongwei Lei, Yali Dou, Monica Guzman, Luke Peterson, Tanja Gruber, Sarah Choi, Duxin Sun, Pingda Ren, Lian-Sheng Li, Yi Liu, Francis Burrows, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Publikováno v:
J Clin Invest
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin 1 (NPM1) gene. As a step toward clinical translatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a63bac5d71d2f2ceab7e25e535675
https://europepmc.org/articles/PMC6994154/
https://europepmc.org/articles/PMC6994154/
Autor:
Ulf Peters, Rasmus Hansen, Matthew R. Janes, Lian-Sheng Li, Patrick Parvis Zarrinkar, Anjali Babbar, Jun Feng, Yuching Chen, Pingda Ren, Yi Liu
Publikováno v:
Nature Structural & Molecular Biology. 25:454-462
Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the discovery of the covalent KRASG12C inhibitors ARS-853 and ARS-1620 has demonstrated that it
Autor:
Aixin Guo, Jianshe Kong, Pingda Ren, Xiaohu Deng, Lian-Sheng Li, Wanping Mai, Ma Rujian, Tao Wu, Jun Zhang, Yun Hu, Haiyu Wang, Yi Wang
Publikováno v:
Organic Process Research & Development. 22:97-102
We report a five-step synthesis of 2-cyano-5-formyl-4-methyl-1H-indole through sequential functionalization of readily available 4-methyl-1H-indole. Cyano and aldehyde functionalities are regioselectively installed at the 2 and 5 position, respective
Autor:
Rasmus, Hansen, Ulf, Peters, Anjali, Babbar, Yuching, Chen, Jun, Feng, Matthew R, Janes, Lian-Sheng, Li, Pingda, Ren, Yi, Liu, Patrick P, Zarrinkar
Publikováno v:
Nature structuralmolecular biology. 25(6)
Activating mutations in KRAS are among the most common tumor driver mutations. Until recently, KRAS had been considered undruggable with small molecules; the discovery of the covalent KRAS