Zobrazeno 1 - 10
of 129
pro vyhledávání: '"PingAr, Yang"'
Autor:
PingAr Yang, Jake Y. Chen, Peter D. Burrows, Shanrun Liu, Huixian Hong, John D. Mountz, Hui-Chen Hsu, Min Gao, Qi Wu, Hao Li, Daniel J. Cua
Publikováno v:
J Immunol
IL-23 promotes autoimmune disease, including Th17 CD4 T cell development and autoantibody production. In this study, we show that a deficiency of the p19 component of IL-23 in the autoimmune BXD2 (BXD2-p19−/−) mouse leads to a shift of the follic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa180bed6c4dd9ba4b13d8147e2dd44
https://doi.org/10.4049/jimmunol.2000280
https://doi.org/10.4049/jimmunol.2000280
Autor:
PingAr Yang, Shanrun Liu, Qi Wu, Hui-Chen Hsu, Bao Luo, John D. Mountz, Alexa L. Mattheyses, Jennie A Hamilton, Jun Li, Ignacio Sanz, W. Winn Chatham
Publikováno v:
The Journal of Immunology. 201:2203-2208
In systemic lupus erythematosus (SLE), type I IFNs promote induction of type I IFN–stimulated genes (ISG) and can drive B cells to produce autoantibodies. Little is known about the expression of distinct type I IFNs in lupus, particularly high-affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538f3c0766570d0dc2bfd1b6c1e6e2cc
https://doi.org/10.4049/jimmunol.1800791
https://doi.org/10.4049/jimmunol.1800791
Autor:
Shanrun Liu, PingAr Yang, Hui-Chen Hsu, John D. Mountz, Mark R. Walter, Bao Luo, Jennie A Hamilton, Jun Li, Eleanor N. Fish, Qi Wu, Huixian Hong
Publikováno v:
The Journal of Immunology. 199:2618-2623
The transitional stage of B cell development is a formative stage in the spleen where autoreactive specificities are censored as B cells gain immune competence, but the intrinsic and extrinsic factors regulating survival of transitional stage 1 (T1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234cdcd7d6943603cf14e94e7ef5409a
https://doi.org/10.4049/jimmunol.1700888
https://doi.org/10.4049/jimmunol.1700888
Autor:
Hui-Chen Hsu, Shanrun Liu, Bao Luo, Oluwagbemiga Ojo, PingAr Yang, John D. Mountz, Jennie A Hamilton, Qi Wu, W. Winn Chatham, Alex Essman
Publikováno v:
Abstracts.
Background Dysregulated responses to type I interferons (IFNs) is a hallmark of autoreactive B-cell development in SLE. This study investigated the source of IFN, the major type I IFN responsive B cells, and the disparities associated with B-cell IFN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7426d08c3b1478f2b4961af07143922
https://doi.org/10.1136/lupus-2019-lsm.192
https://doi.org/10.1136/lupus-2019-lsm.192
Publikováno v:
The Journal of Immunology. 204:218.8-218.8
We have recently identified that down-regulation of interleukin-4 receptor (IL-4R) is a novel hallmark of B-cell dysregulation in SLE patients. Single cell transcriptomics analysis revealed that elevation of IL4R in pre-switched B cells is the opposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538e36e440984a815e8e2bbf5e5b0a70
https://doi.org/10.4049/jimmunol.204.supp.218.8
https://doi.org/10.4049/jimmunol.204.supp.218.8
Autor:
John D. Mountz, Min Gao, Shanrun Liu, Zechen Chong, Qi Wu, PingAr Yang, W. Winn Chatham, Hui-Chen Hsu
Publikováno v:
The Journal of Immunology. 204:219.12-219.12
The most specific predictor for systemic lupus erythematosus (SLE) and lupus nephritis (LN) is the presence of anti-Smith (Sm) autoAb. Mechanisms leading to selection bias for anti-Sm development is unclear. We found that anti-Sm levels in SLE correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::130d900b732320cb8c6949d58e83110a
https://doi.org/10.4049/jimmunol.204.supp.219.12
https://doi.org/10.4049/jimmunol.204.supp.219.12
Autor:
Huixian Hong, Qi Wu, PingAr Yang, Wayne Duck, Casey D. Morrow, Jeremy B. Foote, Trenton R. Schoeb, Charles O. Elson, Hui-Chen Hsu, John D. Mountz
Publikováno v:
The Journal of Immunology. 204:141.3-141.3
The onset and severity of autoimmunity can be attributed to both genetic predisposition and environmental triggers including intestinal microbiota dysbiosis. To determine if development of spontaneous autoimmunity is dependent on gut microbiota, we g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f434dbdb9514605cc44bdfd20dd9de9
https://doi.org/10.4049/jimmunol.204.supp.141.3
https://doi.org/10.4049/jimmunol.204.supp.141.3
Autor:
PingAr Yang, William A Essman, John D. Mountz, Hui-Chen Hsu, Jun Li, W. Winn Chatham, Qi Wu, Bao Luo, Jennie A Hamilton, Shanrun Liu, Ojo Oluwagbemiga A
Publikováno v:
Innate Immunity.
Background Increased type I interferon (IFN) has been shown to affect survival and activation of B cells in SLE. This study investigated novel mechanisms of endogenous production and autocrine activity of IFNβ in SLE B cells at the single-cell level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::802f6c7df2f50bb764a37a1860fe6f92
https://doi.org/10.1136/lupus-2018-lsm.104
https://doi.org/10.1136/lupus-2018-lsm.104
Autor:
Jennie A Hamilton, John D. Mountz, PingAr Yang, Qi Wu, Bao Luo, Shanrun Liu, Iñaki Sanz, W. Winn Chatham, Hui-Chen Hsu, Jun Li
Publikováno v:
Auto Antibodies.
Background Dysregulated responses to type I interferons (IFNs) is a hallmark of autoreactive B cell development in SLE patients. High sera levels of type I IFN protein were recently shown to occur in the absence of increased circulating pDCs and in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c76bbf214117913165b9fbace19443
https://doi.org/10.1136/lupus-2018-lsm.24
https://doi.org/10.1136/lupus-2018-lsm.24
Autor:
Yanna Ding, Hui-Chen Hsu, John D. Mountz, Qi Wu, Bao Luo, Oliver Wildner, PingAr Yang, Allan J. Zajac, Jun Li
Publikováno v:
Arthritis & Rheumatology. 66:2601-2612
Objective Follicular regulatory T (Tfr) cells act as the regulatory counterpart of follicular helper T (Tfh) cells to suppress germinal center (GC) B cell differentiation. We recently showed that interleukin-21 (IL-21) promoted Tfh cell differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eabed664c99d101b512f9effe508ec61
https://doi.org/10.1002/art.38735
https://doi.org/10.1002/art.38735