Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ping K. Yip"'
Autor:
Divyen K. Shah, Vennila Ponnusamy, Jane Evanson, Olga Kapellou, Georgia Ekitzidou, Neelam Gupta, Paul Clarke, Adina T. Michael-Titus, Ping K. Yip
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a604b1ec4ca5457aa2c4384a856dcb1d
Publikováno v:
Open Biology, Vol 13, Iss 12 (2023)
The mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are poorly understood. The normal plasma protein, serum amyloid P component (SAP), which is normally rigorously excluded from the brain, is directly neurocytotoxic f
Externí odkaz:
https://doaj.org/article/7091460bda894d59b4dd0f7551b04262
Autor:
Simon C. Dyall, Isabell Nessel, Jennine A. Sharpe, Ping K. Yip, Adina T. Michael-Titus, Divyen K. Shah
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Hypoxic–ischemic encephalopathy (HIE) is a major cause of neonatal morbidity and mortality. Although therapeutic hypothermia is an effective treatment, substantial chronic neurological impairment often persists. The long-chain omega-3 polyunsaturat
Externí odkaz:
https://doaj.org/article/a36c9e28fe004dd38b288466668671cb
Autor:
Manuel H. Janeiro, Maite Solas, Josune Orbe, Jose A. Rodríguez, Leyre Sanchez de Muniain, Paula Escalada, Ping K. Yip, Maria J. Ramirez
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17557 (2023)
In this study, the plausible role of trimethylamine N-oxide (TMAO), a microbiota metabolite, was investigated as a link between peripheral inflammation and the inflammation of the central nervous system using different cell lines. TMAO treatment favo
Externí odkaz:
https://doaj.org/article/cb8d50dbe7244b758441202c8261c127
Autor:
Ping K. Yip, Michael Bremang, Ian Pike, Vennila Ponnusamy, Adina T. Michael-Titus, Divyen K. Shah
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1471 (2023)
Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality globally. Although mild therapeutic hypothermia (TH) may improve outcomes in selected babies, the mechanism of action is not fully understood. A proteomics discov
Externí odkaz:
https://doaj.org/article/5455a45f6e3141d7a65bdc0952f959dd
Autor:
Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Using next generation sequencing of dried blood spots and subsequent validation, Ponnusamy et al identify let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy. Using cell culture and murine models of perinatal brain in
Externí odkaz:
https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 603 (2022)
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system. Accura
Externí odkaz:
https://doaj.org/article/32f5ae84f38b4d6d9487f93e09cf48a1
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 518 (2022)
Traumatic brain injury (TBI) is an extremely complex disease and current systems classifying TBI as mild, moderate, and severe often fail to capture this complexity. Neuroimaging cannot resolve the cellular and molecular changes due to lack of resolu
Externí odkaz:
https://doaj.org/article/1b7c4ae3ef7a4df38e4be9dd8f301cbb
Autor:
Divyen K. Shah, Ping K. Yip, Akif Barlas, Pavithira Tharmapoopathy, Vennila Ponnusamy, Adina T. Michael-Titus, Philippa Chisholm
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Aim: To determine the predictive value of plasma neurofilament light protein (NfL) as a prognostic marker for outcomes in babies who have undergone therapeutic hypothermia (TH) for hypoxic ischemic encephalopathy (HIE).Method: NfL levels from three g
Externí odkaz:
https://doaj.org/article/fa118f3f1373492c86894a53dc1adcc8
Autor:
Zhuo-Hao Liu, Yin-Cheng Huang, Chang-Yi Kuo, Chi-Cheng Chuang, Ching-Chang Chen, Nan-Yu Chen, Ping K. Yip, Jyh-Ping Chen
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 321 (2022)
To restore lost functions while repairing the neuronal structure after spinal cord injury (SCI), pharmacological interventions with multiple therapeutic agents will be a more effective modality given the complex pathophysiology of acute SCI. Toward t
Externí odkaz:
https://doaj.org/article/7f212d6bb37c450f909757b3c4b969a9