Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Ping‐Yee Law"'
Autor:
Lining Liang, Jinlong Chen, Yuan Li, Xiaowei Lai, Hao Sun, Changpeng Li, Mengdan Zhang, Tingting Yang, Fei Meng, Ping-Yee Law, Horace H. Loh, Hui Zheng
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3625-3631.e6 (2020)
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction. However, the complex functions of opioids and the lo
Externí odkaz:
https://doaj.org/article/6536df257aa64bafb263e3ca5dd852f4
Autor:
Lei Zhang, Cherkaouia Kibaly, Yu‐Jun Wang, Chi Xu, Kyu Young Song, Patrick W McGarrah, Horace H Loh, Jing‐Gen Liu, Ping‐Yee Law
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 11, Pp 1521-1536 (2017)
Abstract Opiate withdrawal/negative reinforcement has been implicated as one of the mechanisms for the progression from impulsive to compulsive drug use. Increase in the intracellular cAMP level and protein kinase A (PKA) activities within the neuroc
Externí odkaz:
https://doaj.org/article/9497773952d5463cb90d28ececad52aa
Autor:
Hui Zheng, Horace H. Loh, Fei Meng, Ping-Yee Law, Lining Liang, Hao Sun, Yuan Li, Changpeng Li, Qian Li
Publikováno v:
Cellular and Molecular Neurobiology. 41:1031-1038
Opioids, like morphine and naloxone, regulate the proliferation and neuronal differentiation of neural stem cells (NSCs) in a receptor-independent and ten-eleven translocation methylcytosine dioxygenase (TET1)-dependent manner in vitro. Whether nalox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa4a01ad917578f6d4d3c192fea9921
https://doi.org/10.1007/s10571-020-00970-8
https://doi.org/10.1007/s10571-020-00970-8
Autor:
Qiaoran Xu, Duanqing Pei, Jingcai He, Yixin Zhang, Tingting Yang, Jinlong Chen, Hui Zheng, Lining Liang, Xiaowei Lai, Mengdan Zhang, Ping-Yee Law, Changpeng Li, Qian Li, Meiai He, Yuan Li, Horace H. Loh, Hao Sun, Fei Meng
Publikováno v:
The FASEB Journal. 34:5917-5930
The abilities of opioids to activate downstream signaling pathways normally depend on the binding between opioids and their receptors. However, opioids may also function in a receptor-independent manner, especially in neural stem cells (NSCs) in whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27843f4411e344aa68f004a5c8329404
https://doi.org/10.1096/fj.201902873r
https://doi.org/10.1096/fj.201902873r
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1153-1162 (2012)
Cholesterol regulates the signaling of µ-opioid receptor in cell models, but it has not been demonstrated in mice or humans. Whether cholesterol regulates the signaling by mechanisms other than supporting the entirety of lipid raft microdomains is s
Externí odkaz:
https://doaj.org/article/af1beb77427f4fb2a6768413e1a7ad94
Publikováno v:
The Scientific World Journal, Vol 2016 (2016)
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor c
Externí odkaz:
https://doaj.org/article/6b82881c9c6b45189db6a35020aaea0c
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153628 (2016)
The regulation of adult neurogenesis by opiates has been implicated in modulating different addiction cycles. At which neurogenesis stage opiates exert their action remains unresolved. We attempt to define the temporal window of morphine's inhibition
Externí odkaz:
https://doaj.org/article/4bb56e692f7e49969c3194553de62078
Autor:
Shu-Yu Lin, Ya-Wen Tien, Yi-Yu Ke, Yung-Chiao Chang, Hsiao-Fu Chang, Li-Chin Ou, Ping-Yee Law, Jing-Hua Xi, Pao-Luh Tao, Horace H. Loh, Yu-Sheng Chao, Chuan Shih, Chiung-Tong Chen, Shiu-Hwa Yeh, Shau-Hua Ueng
Publikováno v:
Bioorganic chemistry. 128
We identified, via high-throughput screening using a FLIPR® calcium assay, compound 1, which incorporated a dihydroquinolinyl-2-oxoethylsulfanyl-(1H,5H)-pyrimidinedione core and activated the μ-opioid receptor (MOR) in the presence of naloxone or n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a5add0e18ce226db7cddf6d10fe250
https://pubmed.ncbi.nlm.nih.gov/35710525
https://pubmed.ncbi.nlm.nih.gov/35710525
Autor:
Shau-Hua Ueng, Jing Hua Xi, Ya Wen Tien, Yu-Sheng Chao, Chuan Shih, Yi Yu Ke, Chiung-Tong Chen, Pao-Luh Tao, Shu Yu Lin, Wan Ting Chang, Ping-Yee Law, Hsiao Fu Chang, Horace H. Loh, Li Chin Ou, Yu Hsien Kuo, Shiu Hwa Yeh
Publikováno v:
European Journal of Medicinal Chemistry. 167:312-323
Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d01c192b0f1f728e3e8f374a361e466
https://doi.org/10.1016/j.ejmech.2019.01.063
https://doi.org/10.1016/j.ejmech.2019.01.063