Synthesis and Biological Activity of a New Series of N6-Arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-Carboxamido Derivatives of Adenosine-5‘-N-ethyluronamide as A1 and A3 Adenosine Receptor Agonists

Autor: Barbara Cacciari, G. Cristalli, G. Spalluto, Xiao-duo Ji, Pineda de Las Infantas Mj, Volpini R, R. Romagnoli, Kenneth A. Jacobson, Neli Melman, Stefano Costanzi, S. Vittori, Park Ks, Pier Giovanni Baraldi

Publikováno v: Journal of Medicinal Chemistry. 41:3174-3185

A new series of 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-d-ribofuranuronamide-bearing N-arylureas or N-arylcarboxamido groups at the purine 6 position and N-arylureas combined with halogens or alkynyl chains at the 2 position have been synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4be7bfe36dc02ac46bd2b35ea984bbc9
https://doi.org/10.1021/jm980147p

Pyridazine nucleus: a pharmacophoric moiety for bio-active compounds

Autor: Baraldi, Pier Giovanni, Cacciari, Barbara, Zaid, An, PINEDA DE LAS INFANTAS MJ, Romagnoli, Romeo, Spalluto, G.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3709::a75719cfc616e7aa28222e7ef6217124
http://hdl.handle.net/11392/1197622

Synthesis and screening of 6-alkoxy purine analogs as cell type-selective apoptotic inducers in Jurkat cells.

Autor: Lorente-Macías Á; Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry Applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Granada, Spain.; Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain., Iañez I; Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain., Jiménez-López MC; Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain., Benítez-Quesada M; Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry Applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Granada, Spain., Torres-Rusillo S; Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain., Díaz-Mochón JJ; Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry Applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Granada, Spain., Molina IJ; Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain., Pineda de Las Infantas MJ; Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry Applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Granada, Spain.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Oct; Vol. 354 (10), pp. e2100095. Date of Electronic Publication: 2021 Jun 15.

NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives.

Autor: López-Cara LC; Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain., Pineda de las Infantas MJ, Carrión MD, Camacho ME, Gallo MA, Espinosa A, Entrena A

Publikováno v: Magnetic resonance in chemistry : MRC [Magn Reson Chem] 2009 Dec; Vol. 47 (12), pp. 1101-9.

Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.

Autor: Baraldi PG; Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy. pgb@dns.unife.it, Fruttarolo F, Tabrizi MA, Romagnoli R, Preti D, Bovero A, Pineda de Las Infantas MJ, Moorman A, Varani K, Borea PA

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 Oct 21; Vol. 47 (22), pp. 5535-40.