Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pinar Siyah"'
Autor:
Firat Baris Barlas, Bilge Olceroglu, Didem Ag Seleci, Zinar Pinar Gumus, Pinar Siyah, Meriam Dabbek, Georg Garnweitne, Frank Stahl, Thomas Scheper, Suna Timur
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Cancer remains a formidable global health challenge, currently affecting nearly 20 million individuals worldwide. Due to the absence of universally effective treatments, ongoing research explores diverse strategies to combat this
Externí odkaz:
https://doaj.org/article/2a9fadbe70834f90b979fcd9ee8ccbbd
Autor:
Pinar Siyah
Publikováno v:
Computation, Vol 12, Iss 11, p 222 (2024)
Synthetic lethality, involving the simultaneous deactivation of two genes, disrupts cellular functions or induces cell death. This study examines its role in cancer, focusing on focal adhesion kinase and Neurofibromin 2. Inhibiting FAK, crucial for s
Externí odkaz:
https://doaj.org/article/2b5b6233e6a34604963d03760b2e5ab6
Autor:
Nermin Basak Sentürk, Burcu Kasapoglu, Eray Sahin, Orhan Ozcan, Mehmet Ozansoy, Muzaffer Beyza Ozansoy, Pinar Siyah, Ugur Sezerman, Fikrettin Sahin
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1334 (2024)
Background/Objectives: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique elec
Externí odkaz:
https://doaj.org/article/71cbb018110d41b994073e5b9c9cbd23
Autor:
Ulviyye Nemetova, Pınar Si̇yah, Tuğçe Boran, Çiğdem Bi̇lgi̇, Mustafa Özyürek, Sibel Şahi̇nler Ayla
Publikováno v:
ACS Omega, Vol 9, Iss 38, Pp 39733-39742 (2024)
Externí odkaz:
https://doaj.org/article/ec3759e235b6471aa890e01c2d2c6b2a
Publikováno v:
RSC Med Chem
Eukaryotic elongation factor 2 kinase (eEF2K) has been shown to be an important molecular driver of tumorigenesis and validated as a potential novel molecular target in various solid cancers including triple negative breast cancer (TNBC). Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310d5f1a7d9b9e52fd77bc1201466e74
https://doi.org/10.1039/d2md00105e
https://doi.org/10.1039/d2md00105e
Publikováno v:
Biophysical Journal. 122:144a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c14ea4680597f83ce6f87fc2c4c815
https://doi.org/10.1016/j.bpj.2022.11.942
https://doi.org/10.1016/j.bpj.2022.11.942
Publikováno v:
The Biochemical journal. 478(18)
OTU proteases antagonize the cellular defense in the host cells and involve in pathogenesis. Intriguingly, P. falciparum, P. vivax, and P. yoelii have an uncharacterized and highly conserved viral OTU-like proteins. However, their structure, function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e985d32e16ed09c704ac40dfae9747b
https://pubmed.ncbi.nlm.nih.gov/34486667
https://pubmed.ncbi.nlm.nih.gov/34486667
Publikováno v:
Progress in Molecular Biology and Translational Science ISBN: 9780323853231
The CRISPR/Cas9 is a RNA-guided nuclease complex that can be specifically programmed to target a user-specified DNA sequence. It has been a powerful and effective tool of genome editing. However, off-target activity of the Cas9 nuclease limits its po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d99c707a727f00748e88410afd39dc
https://aperta.ulakbim.gov.tr/record/235844
https://aperta.ulakbim.gov.tr/record/235844
Publikováno v:
SSRN Electronic Journal.
OTU proteases are key proteins of intracellular parasites that antagonize the cellular defenses following the entry into the host cells. Intriguingly, three of the parasitic plasmodium species causing malaria have uncharacterized viral OTU protein-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d7efecf7c632f474245cd1a05531d2
https://doi.org/10.2139/ssrn.3773786
https://doi.org/10.2139/ssrn.3773786
Autor:
Raife Dilek Turan, Zafer Gulbas, Serdar Durdagi, Fatih Kocabas, Neslihan Meric, Galip Servet Aslan, Merve Uslu, Batuhan Mert Kalkan, Lamia Yazgi Alyazici, Esra Albayrak, Dogacan Yucel, Emre Can Tuysuz, Merve Aksoz, Pinar Siyah
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Meis1, which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors of MEIS1 remained unknown. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110638913d5b08f77ddb7852d16669a6
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8879
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8879