Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pinar S. Gurel"'
Publikováno v:
eLife, Vol 6 (2017)
Despite extensive scrutiny of the myosin superfamily, the lack of high-resolution structures of actin-bound states has prevented a complete description of its mechanochemical cycle and limited insight into how sequence and structural diversification
Externí odkaz:
https://doaj.org/article/28df26c4926a470896c6253ed6523571
Autor:
Michael R. Bowl, Arik Shams, Zane G. Moreland, Matthew J. Reynolds, Santiago Reyes, Gregory M. Alushin, Fangfang Jiang, Jonathan E. Bird, Rui Gong, Pinar S. Gurel
SummaryThe motor protein myosin-15 is necessary for the development and maintenance of mechanosensory stereocilia, and myosin-15 mutations cause profound deafness. In a companion study, we report that myosin-15 nucleates actin filament (“F-actin”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f42218725ff63a7bec8fd7ab787a2a
https://doi.org/10.1101/2021.07.09.451843
https://doi.org/10.1101/2021.07.09.451843
Autor:
Laura Y. Kim, Clarence Yu Cheng, Paul V. Ruijgrok, Rhiju Das, Gregory M. Alushin, Zev Bryant, Tosan Omabegho, Pinar S. Gurel
Publikováno v:
Nature nanotechnology
Engineering biomolecular motors can provide direct tests of structure-function relationships and customized components for controlling molecular transport in artificial systems or in living cells. In previous work, synthetic nucleic acid motors have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175bf568dc721dac6b367e7df3e3d5df
https://doi.org/10.1038/s41565-017-0005-y
https://doi.org/10.1038/s41565-017-0005-y
Academic research institutes have a responsibility to train the next generation of scientists in safe, inclusive environments. However, recent data has shown an increasingly worrying trend of early career researchers (ECRs), particularly underreprese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878354234563ac14ad71e671efc17fba
Autor:
Laura Y. Kim, Paul V. Ruijgrok, Zev Bryant, Tosan Omabegho, Pinar S. Gurel, Gregory M. Alushin
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Despite extensive scrutiny of the myosin superfamily, the lack of high-resolution structures of actin-bound states has prevented a complete description of its mechanochemical cycle and limited insight into how sequence and structural diversification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78f7ade6f1eaf7b6689228a078c7889
http://europepmc.org/articles/PMC5762158
http://europepmc.org/articles/PMC5762158
Publikováno v:
Current Biology. 24(14):R660-R672
A tendency in cell biology is to divide and conquer. For example, decades of painstaking work have led to an understanding of endoplasmic reticulum (ER) and Golgi structure, dynamics, and transport. In parallel, cytoskeletal researchers have revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bfb8238fbd47f3c2477c3746657c53
Autor:
Shivani Sharma, JungReem Woo, Emil Reisler, Pinar S. Gurel, Henry N. Higgs, Elena E. Grintsevich, James K. Gimzewski
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids, vol 30, iss 25
Sharma, S; Grintsevich, EE; Woo, J; Gurel, PS; Higgs, HN; Reisler, E; et al.(2014). Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopy. Langmuir, 30(25), 7533-7539. doi: 10.1021/la501748x. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9w0375s9
Langmuir
Sharma, S; Grintsevich, EE; Woo, J; Gurel, PS; Higgs, HN; Reisler, E; et al.(2014). Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopy. Langmuir, 30(25), 7533-7539. doi: 10.1021/la501748x. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9w0375s9
Langmuir
Self-organization of cytoskeletal proteins such as actin and tubulin into filaments and microtubules is frequently assisted by the proteins binding to them. Formins are regulatory proteins that nucleate the formation of new filaments and are essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae234a9d137a96870e8a687438793c5
https://doi.org/10.1021/la501748x
https://doi.org/10.1021/la501748x
Publikováno v:
Journal of Biological Chemistry. 287:34234-34245
INF2 (inverted formin 2) is a formin protein with unusual biochemical characteristics. As with other formins, the formin homology 2 (FH2) domain of INF2 accelerates actin filament assembly and remains at the barbed end, modulating elongation. The uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc12b9f5d2759ff8412bfc705ccf05f6
https://doi.org/10.1074/jbc.m112.365122
https://doi.org/10.1074/jbc.m112.365122
Autor:
Michael W. Davidson, Gregory M. Alushin, Hawa Racine Thiam, Colleen T. Skau, Anthony T. Tubbs, Patricia S. Steeg, Pinar S. Gurel, Matthieu Piel, Michelle A. Baird, Clare M. Waterman, Robert S. Fischer, André Nussenzweig
Publikováno v:
Cell. 173:529
Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9e12f54463fccbbc9071cf34aaf2d7
https://doi.org/10.1016/j.cell.2018.03.058
https://doi.org/10.1016/j.cell.2018.03.058