Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Pinar Coskun"'
Autor:
Kunal Thaker, Marilyn Chwa, Shari R. Atilano, Pinar Coskun, Javier Cáceres-del-Carpio, Nitin Udar, David S. Boyer, S. Michal Jazwinski, Michael V. Miceli, Anthony B. Nesburn, Baruch D. Kuppermann, M. Cristina Kenney
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 64-77 (2016)
Mitochondrial (mt) DNA haplogroups, defined by specific single nucleotide polymorphism (SNP) patterns, represent populations of diverse geographic origins and have been associated with increased risk or protection of many diseases. The H haplogroup i
Externí odkaz:
https://doaj.org/article/d6e560fb3fc94d71b46c7c8d58cb7872
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14200 (2010)
Down's syndrome (DS) is the most common genetic cause of mental retardation. Reduced number and aberrant architecture of dendritic spines are common features of DS neuropathology. However, the mechanisms involved in DS spine alterations are not known
Externí odkaz:
https://doaj.org/article/8edcf01576ea481d92c9e3b6026ecf08
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Externí odkaz:
https://doaj.org/article/215b45e0bb7e4eb1bb9306250566d3db
Publikováno v:
Stroke. 53
Background: Urinary Tract Infection (UTI) has been associated with increased cost of care and poor outcomes in stroke patients. Guidelines from the Infectious Disease Society of America do not support treating asymptomatic UTI in the absence of objec
Publikováno v:
Journal of Movement Disorders, Vol 14, Iss 2, Pp 173-175 (2021)
Journal of Movement Disorders
Journal of Movement Disorders
Autor:
Anthony B. Nesburn, Michael V. Miceli, David S. Boyer, S. Michal Jazwinski, Baruch D. Kuppermann, Marilyn Chwa, Shari R. Atilano, Kunal Thaker, Nitin Udar, Javier Cáceres-del-Carpio, Pinar Coskun, M. Cristina Kenney
Publikováno v:
Neurobiology of Disease, Vol 93, Iss, Pp 64-77 (2016)
Mitochondrial (mt) DNA haplogroups, defined by specific single nucleotide polymorphism (SNP) patterns, represent populations of diverse geographic origins and have been associated with increased risk or protection of many diseases. The H haplogroup i
Autor:
Pinar Coskun, Sergio A. Cannas, Emiliano Zamponi, Nahuel Zamponi, Pablo Helguera, Alfredo Lorenzo, Jorge Busciglio, Gonzalo Quassollo, Katheleen Gardiner, Gustavo Pigino, Dante R. Chialvo
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of reactive oxygen species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b894ecceb0cb89ba5e91dc15fc467058
Wiley Online Library
Wiley Online Library
Autor:
Pinar Coskun, Damien J. Keating, Michael D. Duffield, Claire F. Jessup, William C. Mobley, Sean L. McGee, Victor L. J. Tybulewicz, Tertius Hough, Pavel V. Belichenko, João Fadista, Amanda J Genders, Penelope Coates, Melanie April Pritchard, Jorge Busciglio, Ann Becker, Elizabeth M. C. Fisher, Heshan Peiris, Ross Laybutt
Publikováno v:
Diabetes. 64:A1-A100
Autor:
Jorge Busciglio, Ryan C. Bohannan, Pablo Helguera, Jean Thomas, Eric Doran, Schriner E. Samuel, Jocelyn Argueta, Zahra Nemati, Pinar Coskun, Douglas C. Wallace, Ira T. Lott
Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective: We hypothesized that peripheral cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2171022e7666a0906d14bb572d2c6820
https://www.ncbi.nlm.nih.gov/pubmed/27802222
https://www.ncbi.nlm.nih.gov/pubmed/27802222
Autor:
Ann Becker, Pinar Coskun, Petr Volkov, Vinder Kashmir, Nikolay Oskolkov, Claire F. Jessup, Heshan Peiris, Michael T. Ryan, William C. Mobley, Amanda J Genders, Nicholas M. Morton, Alyce M. Martin, D. Ross Laybutt, Michael D. Duffield, Michael A. Cousin, João Fadista, Jeng Yie Chan, Sean L. McGee, Leif Groop, Alexandros C. Kokotos, Victor L. J. Tybulewicz, Tertius Hough, Elizabeth M. C. Fisher, Melanie April Pritchard, Jorge Busciglio, P. Toby Coates, Roderick N. Carter, Charlotte Ling, Madiha Saiedi, Sijun Yang, Pavel V. Belichenko, Damien J. Keating
Publikováno v:
Peiris, H; Duffield, MD; Fadista, J; Jessup, CF; Kashmir, V; Genders, AJ; et al.(2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genetics, 12(5). doi: 10.1371/journal.pgen.1006033. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/69g1d108
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a79e00f46b9b13910b1e47b75ca457
http://www.escholarship.org/uc/item/69g1d108
http://www.escholarship.org/uc/item/69g1d108