Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Pin-Kuang Lai"'
Autor:
Ibrahim Wichka, Pin-Kuang Lai
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3669-3679 (2024)
Celiac disease poses a significant health challenge for individuals consuming gluten-containing foods. While the availability of gluten-free products has increased, there is still a need for therapeutic treatments. The advancement of computational dr
Externí odkaz:
https://doaj.org/article/cf856de826aa42019b81ec5742025b4b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2220-2229 (2024)
Therapeutic antibody development faces challenges due to high viscosities and aggregation tendencies. The spatial charge map (SCM) and spatial aggregation propensity (SAP) are computational techniques that aid in predicting viscosity and aggregation,
Externí odkaz:
https://doaj.org/article/fadb7dbfba6a45bd8604a5eb6936ffd2
Autor:
Pin-Kuang Lai
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2143-2152 (2022)
Predicting high concentration antibody viscosity is essential for developing subcutaneous administration. Computer simulations provide promising tools to reach this aim. One such model is the spatial charge map (SCM) proposed by Agrawal and coworkers
Externí odkaz:
https://doaj.org/article/17fa73f9859340e29970e123fa131faa
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Machine learning has been recently used to predict therapeutic antibody aggregation rates and viscosity at high concentrations (150 mg/ml). These works focused on commercially available antibodies, which may have been optimized for stability. In this
Externí odkaz:
https://doaj.org/article/f4ca71bf37414333844364400a211ee9
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-10 (2018)
Abstract Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and DNAs for local and distant inte
Externí odkaz:
https://doaj.org/article/bc1b2a308f484050bc9b5aaf1ff9ce47
Autor:
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This
Externí odkaz:
https://doaj.org/article/944b83f5f34449e7a67f388df2b8013b
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies. The viscosity is determined by protein–protein interactions among many antibodies. Molecular simulation is a promising method to study protein–prot
Externí odkaz:
https://doaj.org/article/a8d3524eb652421da213579340202493
Autor:
Anthony Yan‐Tang Wu, Yun‐Chieh Sung, Yen‐Ju Chen, Steven Ting‐Yu Chou, Vanessa Guo, Jasper Che‐Yung Chien, John Jun‐Sheng Ko, Alan Ling Yang, Hsi‐Chien Huang, Ju‐Chen Chuang, Syuan Wu, Meng‐Ru Ho, Maria Ericsson, Wan‐Wan Lin, Chantal Hoi Yin Cheung, Hsueh‐Fen Juan, Koji Ueda, Yunching Chen, Charles Pin‐Kuang Lai
Publikováno v:
Advanced Science, Vol 7, Iss 19, Pp n/a-n/a (2020)
Abstract Extracellular particles (EPs) including extracellular vesicles (EVs) and exomeres play significant roles in diseases and therapeutic applications. However, their spatiotemporal dynamics in vivo have remained largely unresolved in detail due
Externí odkaz:
https://doaj.org/article/507974afa10f4003ae2bcbf96bda1580
Autor:
Pin-Kuang Lai, Yiannis N. Kaznessis
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 6056-6065 (2018)
Externí odkaz:
https://doaj.org/article/87a679bbc6c04511a36d0566c8d6adcd
Autor:
Mikołaj Piotr Zaborowski, Kyungheon Lee, Young Jeong Na, Alessandro Sammarco, Xuan Zhang, Marcin Iwanicki, Pike See Cheah, Hsing-Ying Lin, Max Zinter, Chung-Yu Chou, Giulia Fulci, Bakhos A. Tannous, Charles Pin-Kuang Lai, Michael J. Birrer, Ralph Weissleder, Hakho Lee, Xandra O. Breakefield
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 255-268.e6 (2019)
Summary: Analysis of cancer-derived extracellular vesicles (EVs) in biofluids potentially provides a source of disease biomarkers. At present there is no procedure to systematically identify which antigens should be targeted to differentiate cancer-d
Externí odkaz:
https://doaj.org/article/f5811ae8179b4dfaa6de8cd19a6060d7