Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pin-Hsuan Lu"'
Autor:
Pin-Hsuan Lu, 呂品璇
104
Prostate cancer is the sixth leading cause of cancer death in Taiwan. The androgen- independent prostate cancer (AIPC) cells constitutively express abundant amount of the Interleukin-8 (IL-8) which has been identified in term of prostate can
Prostate cancer is the sixth leading cause of cancer death in Taiwan. The androgen- independent prostate cancer (AIPC) cells constitutively express abundant amount of the Interleukin-8 (IL-8) which has been identified in term of prostate can
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/f8x7h2
Autor:
Pin-Hsuan Lu, 盧品璇
98
Metastatic hormone resistant prostate cancer is the major cause of death in patients with prostate cancers. Therefore, drug discovery against metastatic prostate cancers is highlighted currently. The goal of anticancer therapy is to inhibit g
Metastatic hormone resistant prostate cancer is the major cause of death in patients with prostate cancers. Therefore, drug discovery against metastatic prostate cancers is highlighted currently. The goal of anticancer therapy is to inhibit g
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/88451506450943398847
Autor:
Po-Cheng Chiang, Jih-Hwa Guh, Yi-Cheng Chen, Chia-Chun Yu, Yunn-Fang Ho, Fan-Lu Kung, Pin-Hsuan Lu
Publikováno v:
Journal of Urology. 186:2434-2441
Emerging evidence shows that the translocation of apoptosis related factors on cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus and nucleus, has a crucial role in the apoptotic process. We characterized the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3700c5d0b2dc83af31d8b3375891b072
https://doi.org/10.1016/j.juro.2011.07.088
https://doi.org/10.1016/j.juro.2011.07.088
Publikováno v:
Toxicology and Applied Pharmacology. 257:412-419
Poly(ADP-ribose) polymerase-1 (PARP-1), a sensor of DNA damage, plays a crucial role in the regulation of DNA repair. PARP-1 hyperactivation causes DNA damage and cell death. The underlying mechanism is complicated and is through diverse pathways. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5f2e87914118fba43f35cb8c47eed9
https://doi.org/10.1016/j.taap.2011.09.025
https://doi.org/10.1016/j.taap.2011.09.025
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 382:159-169
Comprehensive studies support the notion that selective inhibitors of cyclooxygenase-2 (COX-2) display anticancer activities in numerous types of cancer cells, including prostate cancers. Our previous study showed that the benzodithiazolium-based com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb9a3351897cdce5ad60c5617fdd8d6
https://doi.org/10.1007/s00210-010-0528-3
https://doi.org/10.1007/s00210-010-0528-3
Autor:
Yu-Chun Huang, Ying Cheng Chen, Tsung Ping Lin, Yunn-Fang Ho, Shiow Lin Pan, Pin Hsuan Lu, Sheng-Chu Kuo, Che-Ming Teng, Jih-Hwa Guh
Publikováno v:
Biochemical Pharmacology. 74:10-19
Cancer chemotherapeutic agents that interfere with tubulin/microtubule function are in extensive use. Quinolone is a common structure in alkaloids and its related components exhibit several pharmacological activities. In this study, we have identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dcc31e4d41d40601c1bf3586f33198
https://doi.org/10.1016/j.bcp.2007.03.015
https://doi.org/10.1016/j.bcp.2007.03.015
Publikováno v:
European Journal of Pharmacology. 556:45-54
The marine organisms produce many metabolic substances with numerous pharmacological activities. It has been suggested that ilimaquinone, a metabolite of sea sponge, can induce vesiculation of the Golgi apparatus and display several biological activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29d112c0ae414002538a8e7ec8e02c2
https://doi.org/10.1016/j.ejphar.2006.10.061
https://doi.org/10.1016/j.ejphar.2006.10.061
Autor:
Ching-Shih Chen, Pui-Kei Leong, Jih-Hwa Guh, Yunn-Fang Ho, Jui-Ling Hsu, Lih-Ching Hsu, Pin-Hsuan Lu
Publikováno v:
Cancer letters. 319(2)
The knockdown of Pim-1 or inhibition of Pim-1 activity significantly increased c-H2A.X expression. The effect was correlated to apoptosis and was attributed to the inhibition of nonhomologous DNA-end-joining (NHEJ) repair activity supported by the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe3b59293f7e968888fb112925cdd44
https://pubmed.ncbi.nlm.nih.gov/22261337
https://pubmed.ncbi.nlm.nih.gov/22261337
Autor:
Mao-Tien Kuo, Po-Cheng Chiang, Peini Chen, Jih-Hwa Guh, Chia-Chun Yu, Pin-Hsuan Lu, Wu-Che Wen
Publikováno v:
The Journal of nutritional biochemistry. 23(8)
Pancreatic cancer is a malignant neoplasm of the pancreas. A mutation and constitutive activation of K-ras occurs in more than 90% of pancreatic adenocarcinomas. A successful approach for the treatment of pancreatic cancers is urgent. Antroquinonol,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e18eedff084f9b871c0c83e49c4c9df
https://pubmed.ncbi.nlm.nih.gov/21840189
https://pubmed.ncbi.nlm.nih.gov/21840189
Publikováno v:
The Prostate.
BACKGROUND Chalcones are contained in fruits and vegetables, and have been suggested to display anticancer activities. In this study, the anticancer mechanism of WJ9708011 (a methoxychalcone derivative) was delineated in human prostate cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f77df4dc6d5951cdf576729f2477c6
https://doi.org/10.1002/pros.21165
https://doi.org/10.1002/pros.21165