Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pin-Chih Su"'
Autor:
Pin-Chih Su, 蘇品誌
105
Six Sigma is an integrated quality management approach, the application of scientific methods for process analysis, to understand the facts of the data presented and identify key quality characteristics to improve the quality of enterprise p
Six Sigma is an integrated quality management approach, the application of scientific methods for process analysis, to understand the facts of the data presented and identify key quality characteristics to improve the quality of enterprise p
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/77w374
Autor:
Shahila Mehboob, Arun K. Ghosh, Pin Chih Su, Michael E. Johnson, Tina Mistry, Robel Demissie, Leslie W.-M. Fung, Jinhong Ren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2074-2079
We have previously reported benzimidazole-based compounds to be potent inhibitors of FabI for Francisella tularensis (FtFabI), making them promising antimicrobial hits. Optically active enantiomers exhibit markedly differing affinities toward FtFabI.
Autor:
Michael E. Johnson, Pin Chih Su
Publikováno v:
Journal of Computational Chemistry. 37:836-847
Thermodynamic integration (TI) can provide accurate binding free energy insights in a lead optimization program, but its high computational expense has limited its usage. In the effort of developing an efficient and accurate TI protocol for FabI inhi
Publikováno v:
Journal of Computational Chemistry. 36:1859-1873
To validate a method for predicting the binding affinities of FabI inhibitors, three implicit solvent methods, MM-PBSA, MM-GBSA, and QM/MM-GBSA were carefully compared using 16 benzimidazole inhibitors in complex with Francisella tularensis FabI. The
Autor:
Heta B. Chokshi, Tian Zhu, Darshan Shah, Ram Patel, Pin Chih Su, Kirk E. Hevener, Shuyi Cao, Richard Szukala, Michael E. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 56:6560-6572
A critical analysis of virtual screening results published between 2007 and 2011 was performed. The activity of reported hit compounds from over 400 studies was compared to their hit identification criteria. Hit rates and ligand efficiencies were cal
Autor:
Pin-Chih, Su, Michael E, Johnson
Publikováno v:
Journal of computational chemistry. 37(9)
Thermodynamic integration (TI) can provide accurate binding free energy insights in a lead optimization program, but its high computational expense has limited its usage. In the effort of developing an efficient and accurate TI protocol for FabI inhi
Autor:
Jinhua Song, Teuta Boci, Michael E. Johnson, Pin Chih Su, Tina Mistry, Kirk E. Hevener, Jiangping Deng, James L. Cook, Arun K. Ghosh, Shahila Mehboob, Libby Brubaker, Bernard D. Santarsiero, Lena Truong
Francisella tularensis, the causative agent of tularemia, presents a significant biological threat and is a Category A priority pathogen due to its potential for weaponization. The bacterial FASII pathway is a viable target for the development of nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7efe24e3df6fe10243ce4b77a81ddb
https://europepmc.org/articles/PMC4348352/
https://europepmc.org/articles/PMC4348352/
Autor:
Tian, Zhu, Shuyi, Cao, Pin-Chih, Su, Ram, Patel, Darshan, Shah, Heta B, Chokshi, Richard, Szukala, Michael E, Johnson, Kirk E, Hevener
Publikováno v:
Journal of medicinal chemistry. 56(17)
A critical analysis of virtual screening results published between 2007 and 2011 was performed. The activity of reported hit compounds from over 400 studies was compared to their hit identification criteria. Hit rates and ligand efficiencies were cal
The rational design of pharmaceutical agents with activity against bacterial targets presents several unique challenges due to the significant differences in the target bacterial cells and the eukaryotic cells of their mammalian hosts. The structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be116ca211bab17f18f4c858cb7fa113
https://doi.org/10.1016/b978-0-12-417150-3.00018-1
https://doi.org/10.1016/b978-0-12-417150-3.00018-1
Autor:
Shahila Mehboob, Pin Chih Su, Kirk E. Hevener, Teuta Boci, Mahmood Ghassemi, Jiangping Deng, Michael E. Johnson, James L. Cook, Kent Truong
Publikováno v:
Journal of medicinal chemistry. 55(1)
Enoyl-acyl carrier protein (ACP) reductase, FabI, is a key enzyme in the bacterial fatty acid biosynthesis pathway (FAS II). FabI is an NADH-dependent oxidoreductase that acts to reduce enoyl-ACP substrates in a final step of the pathway. The absence