Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pin Yu Chew"'
Autor:
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R. Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G. Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113997- (2024)
Externí odkaz:
https://doaj.org/article/c66fa4fd77ec4f6893dd3fcf44c3f9d3
Autor:
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R. Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G. Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113136- (2023)
Summary: Polycomb repressive complex 1 (PRC1) undergoes phase separation to form Polycomb condensates that are multi-component hubs for silencing Polycomb target genes. In this study, we demonstrate that formation and regulation of PRC1 condensates a
Externí odkaz:
https://doaj.org/article/90f4a766e5c946ce863b02c3e0c6d970
Multiphasic architectures are found ubiquitously in biomolecular condensates and are thought to have important implications for the organisation of multiple chemical reactions within the same compartment. Many of these multiphasic condensates contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f9bbd063dbbe9afcc086087b4f321f
https://doi.org/10.1101/2023.04.05.535720
https://doi.org/10.1101/2023.04.05.535720
Autor:
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R Espinosa, Anne Aguirre, Tatiana Kutateladze, Rosana Collepardo Guevara, Xiaojun Ren
SUMMARYPRC1 (Polycomb repressive complex 1) plays a significant role in cellular differentiation and development by repressing lineage-inappropriate genes. PRC1 proteins phase separate to form Polycomb condensates (bodies) that are multi-component hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1833bbef622f13269e10a07a2c8e6eb6
https://doi.org/10.1101/2022.12.26.521954
https://doi.org/10.1101/2022.12.26.521954
Autor:
Kieran O. Russell, Rosana Collepardo-Guevara, Adiran Garaizar, Anne Aguirre, Jorge R. Espinosa, Jerelle A. Joseph, Pin Yu Chew, Aleks Reinhardt
Publikováno v:
Nature Computational Science
Nat Comput Sci
Nat Comput Sci
Various physics- and data-driven sequence-dependent protein coarse-grained models have been developed to study biomolecular phase separation and elucidate the dominant physicochemical driving forces. Here we present Mpipi, a multiscale coarse-grained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85944a747dfdb2685d0df54e8a21015d
https://doi.org/10.1038/s43588-021-00155-3
https://doi.org/10.1038/s43588-021-00155-3
Publikováno v:
Biophysical Journal. 122:295a-296a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667cd5fe0ae7efb9f70412ec3e900fd7
https://doi.org/10.1016/j.bpj.2022.11.1672
https://doi.org/10.1016/j.bpj.2022.11.1672
Control of biomolecular condensates may hold considerable therapeutic potential. Intracellular condensates are highly multi-component systems in which complex phase behaviour can ensue, including the formation of architectures comprising multiple imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::070f588b53fa5a4344d863a35cffd9b9
https://doi.org/10.1101/2022.04.22.489187
https://doi.org/10.1101/2022.04.22.489187
Autor:
Pin Yu Chew, Aleks Reinhardt
Publikováno v:
The Journal of Chemical Physics. 158:030902
Understanding the thermodynamic stability and metastability of materials can help us to, for example, gauge whether crystalline polymorphs in pharmaceutical formulations are likely to be durable. It can also help us to design experimental routes to n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6aea0c585bd69e621ad26a896113049
https://doi.org/10.1063/5.0131028
https://doi.org/10.1063/5.0131028