Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pin W, Liu"'
Autor:
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 8 (2019)
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://doaj.org/article/de64bb25275445b0a3e4407fe3462af5
Autor:
Pin W. Liu, Hongkang Zhang, Christopher A. Werley, Monika Pichler, Steve Ryan, Caitlin Lewarch, Jane Jacques, Jennifer Grooms, John Ferrante, Guangde Li, Dawei Zhang, Nate Bremmer, Adam Barnett, Romina Chantre, Amy E. Elder, Adam E. Cohen, Luis A. Williams, Graham T. Dempsey, Owen B. McManus
Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. Here, we present anin vitromodel of O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088799b6f5f999c7b434c1b6a4461ccb
https://doi.org/10.1101/2022.12.12.520139
https://doi.org/10.1101/2022.12.12.520139
Autor:
Colin H, Peters, Pin W, Liu, Stefano, Morotti, Stephanie C, Gantz, Eleonora, Grandi, Bruce P, Bean, Catherine, Proenza
Publikováno v:
Proc Natl Acad Sci U S A
Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous action potentials (APs) that initiate each heartbeat. The funny current (I(f)) is critical for the generation of these spontaneous APs; however, its precise role dur
Autor:
Stephanie C. Gantz, Colin H. Peters, Eleonora Grandi, Pin W. Liu, Stefano Morotti, Catherine Proenza, Bruce P. Bean
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous action potentials (APs) that initiate each heartbeat. The funny current (If) is critical for the generation of these spontaneous APs; however, its precise role durin
Autor:
Bruce P. Bean, Colin H. Peters, Catherine Proenza, Stephanie C. Gantz, Pin W. Liu, Stefano Morotti, Eleonora Grandi
Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous action potentials (APs) that initiate each heartbeat. The funny current, If, is critical for the generation of these spontaneous APs; however, its precise role durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375da114e171ffd73c7d79eb6e1f606e
https://doi.org/10.1101/2021.03.10.434820
https://doi.org/10.1101/2021.03.10.434820
Autor:
Gabriel B, Borja, Himali, Shroff, Hansini, Upadhyay, Pin W, Liu, Valeriya, Baru, Yung-Chih, Cheng, Owen B, McManus, Luis A, Williams, Graham T, Dempsey, Christopher A, Werley
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2191
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Autor:
Graham T. Dempsey, Pin W. Liu, Hansini Upadhyay, Gabriel B. Borja, Christopher A. Werley, Valeriya Baru, Himali Shroff, Luis A. Williams, Yung-Chih Cheng, Owen B. McManus
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608296
Optogenetics provides a powerful approach for investigating neuronal electrophysiology at the scale required for drug discovery applications. Probing synaptic function with high throughput using optogenetics requires robust tools that enable both pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb35627916d5e37a95faa9e16f9544b
https://doi.org/10.1007/978-1-0716-0830-2_8
https://doi.org/10.1007/978-1-0716-0830-2_8
Autor:
Masakazu Kotoda, Aakanksha Jain, Michelino Puopolo, Clifford J. Woolf, Nick Andrews, Sooyeon Jo, Thomas Jacquemont, Jinbo Lee, Han-Xiong Bear Zhang, Laurel M. Heckman, Maud Pascal, Sébastien Talbot, Bruce P. Bean, Pin W. Liu, Seungkyu Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f248ef109b663ee9e8597550bb1d46d
https://doi.org/10.7554/elife.48118.sa2
https://doi.org/10.7554/elife.48118.sa2
Autor:
Thomas Jacquemont, Masakazu Kotoda, Clifford J. Woolf, Laurel M. Heckman, Nick Andrews, Bruce P. Bean, Seungkyu Lee, Han-Xiong Bear Zhang, Michelino Puopolo, Sooyeon Jo, Sébastien Talbot, Maud Pascal, Aakanksha Jain, Jinbo Lee, Pin W. Liu
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Publikováno v:
The Journal of Neuroscience. 37:9705-9714
Action potential (AP) shape is a key determinant of cellular electrophysiological behavior. We found that in small-diameter, capsaicin-sensitive dorsal root ganglia neurons corresponding to nociceptors (from rats of either sex), stimulation at freque