Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Pin I. Chen"'
Autor:
Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of Tregs is being clinically evaluated as a novel way to prevent or tr
Externí odkaz:
https://doaj.org/article/9eb5d3e2468049a48285a66700ca2b17
Autor:
Lingli Wang, Jan-Renier Moonen, Aiqin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pin-I. Chen, Mingxia Gu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, Yu-Mee Kim, Kryn Stankunas, Marlene Rabinovitch
Publikováno v:
Circulation Research. 132:545-564
Objective: Mutations in BMPR2 (bone morphogenetic protein receptor 2) are associated with familial and sporadic pulmonary arterial hypertension (PAH). The functional and molecular link between loss of BMPR2 in pulmonary artery smooth muscle cells (PA
Autor:
Xiangni Wu, Pin-I Chen, Shiva Pathak, Robert L Whitener, Vy Nguyen, Bettina P. Iliopolou, Kauhleen R. Mangayan, Kent P. Jensen, Seung K. Kim, Everett H. Meyer
Publikováno v:
Transplantation and Cellular Therapy. 29:S184-S185
Autor:
Toshie Saito, Lingli Wang, Marlene Rabinovitch, Kazuya Miyagawa, Jan K. Hennigs, Caiyun G. Li, Silin Sa, Minyi Shi, Pin-I Chen, Zhixin Zhao, Aiqin Cao, Shalina Taylor, Michael Snyder, Mouer Wang
Publikováno v:
Circulation Research. 124:211-224
Rationale: Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on their metabolic state and gene expression profile, features influenced by contact with neighboring cells such as pericytes and smooth muscle cells (SMC). Failu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90384 (2014)
Rab5, the prototypical Rab GTPase and master regulator of the endocytic pathway, is encoded as three differentially expressed isoforms, Rab5A, Rab5B and Rab5C. Here, we examined the differential effects of Rab5 isoform silencing on cell motility and
Externí odkaz:
https://doaj.org/article/d1b7bf6797af41ce9382624dd5c48451
Autor:
Isabel Diebold, James D. Chappell, Jan K. Hennigs, Marlene Rabinovitch, Pin-I Chen, Aiqin Cao, Matthew Bill, Minyi Shi, Rebecca L. Harper, Caiyun G. Li, Jan-Renier A. J. Moonen, Kazuya Miyagawa, Michael Snyder, David Marciano, Matthew V. Elliott, Julia Mienert, Matthew Roughley, Jakob Körbelin, Lingli Wang
Publikováno v:
Circ Res
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcriptio
Autor:
Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J Wainszelbaum, Audra J Charron, Jialiu Liu, Jeffrey J Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D Stahl
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46485 (2012)
Expression of the hominoid-specific TBC1D3 oncoprotein enhances growth factor receptor signaling and subsequently promotes cellular proliferation and survival. Here we report that TBC1D3 is degraded in response to growth factor signaling, suggesting
Externí odkaz:
https://doaj.org/article/df5dad9cf4ca41f096ab2a0bf2e65be0
Autor:
Zhaoying Xian, Silin Sa, Caiyun G. Li, Christopher J. Rhodes, Michael Snyder, Jan K. Hennigs, Nancy F. Tojais, Rui Chen, Pin-I Chen, Roham T. Zamanian, Kazuya Miyagawa, Rachel K. Hopper, Nils Nickel, Aiqin Cao, Joseph C. Wu, Daniel Bernstein, Mark Kaschwich, Patricia A. del Rosario, Mingming Zhao, Lingli Wang, Edda Spiekerkoetter, Hogune Im, Marlene Rabinovitch, Mingxia Gu
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 192:356-366
Pulmonary arterial hypertension is characterized by endothelial dysregulation, but global changes in gene expression have not been related to perturbations in function.RNA sequencing was used to discriminate changes in transcriptomes of endothelial c
Autor:
Hennigs, Jan K., Aiqin Cao, Li, Caiyun G., Minyi Shi, Mienert, Julia, Miyagawa, Kazuya, Körbelin, Jakob, Marciano, David P., Pin-I Chen, Roughley, Matthew, Elliott, Matthew V., Harper, Rebecca L., Bill, Matthew A., Chappell, James, Moonen, Jan-Renier, Diebold, Isabel, Wang, Lingli, Snyder, Michael P., Rabinovitch, Marlene
Publikováno v:
Circulation Research; 2/5/2021, Vol. 128 Issue 3, p401-418, 18p
Autor:
Francois Haddad, Jan-Renier A. J. Moonen, Lingli Wang, Kazuya Miyagawa, Marlene Rabinovitch, Dan Li, Pin-I Chen, Erik Samayoa, Aiqin Cao, Wendy J. Fantl, Ryan D. Leib, Charles Y. Chiu, Toshie Saito, William H. Robinson, Daisuke Harada, Garry P. Nolan, Rasa Tamosiuniene, Jan K. Hennigs, Patricia A. del Rosario, Matthew Bill, Maria Eugenia Ariza, Roham T. Zamanian, Christopher M. Adams, Mark R. Nicolls, Shih-Yu Chen, Caiyun G. Li, Jose G. Montoya, Mingxia Gu, Orr Sharpe
Background: Immune dysregulation has been linked to occlusive vascular remodeling in pulmonary arterial hypertension (PAH) that is hereditary, idiopathic, or associated with other conditions. Circulating autoantibodies, lung perivascular lymphoid tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664ac0bf0bd3939481c408121a949f7b
https://europepmc.org/articles/PMC5685911/
https://europepmc.org/articles/PMC5685911/