Výsledky vyhledávání - "Pim W. Gilijamse"

Akademický článek

Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production

Autor: Vehpi Yildirim, Kasper W. ter Horst, Pim W. Gilijamse, Dewi van Harskamp, Henk Schierbeek, Hans Jansen, Alinda W.M. Schimmel, Max Nieuwdorp, Albert K. Groen, Mireille J. Serlie, Natal A.W. van Riel, Geesje M. Dallinga-Thie

Publikováno v: JCI Insight, Vol 8, Iss 16 (2023)

Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (R

Externí odkaz: https://doaj.org/article/0f159909912c460780398d2a0da730af

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Akademický článek

The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans

Autor: Kasper W. ter Horst, Pim W. Gilijamse, Ahmet Demirkiran, Bart A. van Wagensveld, Mariette T. Ackermans, Joanne Verheij, Johannes A. Romijn, Max Nieuwdorp, Eleftheria Maratos-Flier, Mark A. Herman, Mireille J. Serlie

Publikováno v: Molecular Metabolism, Vol 6, Iss 11, Pp 1493-1502 (2017)

Objective: Fructose consumption has been implicated in the development of obesity and insulin resistance. Emerging evidence shows that fibroblast growth factor 21 (FGF21) has beneficial effects on glucose, lipid, and energy metabolism and may also me

Externí odkaz: https://doaj.org/article/45fb8f00eaf645dcbdade66a9f0d30fd

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Akademický článek

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

Autor: Kasper W. ter Horst, Pim W. Gilijamse, Ruth I. Versteeg, Mariette T. Ackermans, Aart J. Nederveen, Susanne E. la Fleur, Johannes A. Romijn, Max Nieuwdorp, Dongyan Zhang, Varman T. Samuel, Daniel F. Vatner, Kitt F. Petersen, Gerald I. Shulman, Mireille J. Serlie

Publikováno v: Cell Reports, Vol 19, Iss 10, Pp 1997-2004 (2017)

Hepatic lipid accumulation has been implicated in the development of insulin resistance, but translational evidence in humans is limited. We investigated the relationship between liver fat and tissue-specific insulin sensitivity in 133 obese subjects

Externí odkaz: https://doaj.org/article/1ba88a685b9c4194bdfa1886e409ee3d

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Akademický článek

Sexual dimorphism in hepatic, adipose tissue and peripheral tissue insulin sensitivity in obese humans

Autor: Kasper W. ter Horst, Pim W. Gilijamse, Barbara A. de Weijer, Murat eKilicarslan, Mariette T. Ackermans, Aart J. Nederveen, Max eNieuwdorp, Johannes A. Romijn, Mireille J. Serlie

Publikováno v: Frontiers in Endocrinology, Vol 6 (2015)

Glucose and lipid metabolism differ between men and women, and women tend to have better whole-body or muscle insulin sensitivity. This may be explained, in part, by differences in sex hormones and adipose tissue distribution. Few studies have invest

Externí odkaz: https://doaj.org/article/656c8ee81c6b4e978f1c25fe0fe87adb

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Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

Autor: Steven Aalvink, Andrei Prodan, Han Levels, Evgeni Levin, Hilde Herrema, Albert K. Groen, Morton Sommer, Sultan Imangaliyev, Aart J. Nederveen, Mariëtte T. Ackermans, Erik S.G. Stroes, Annick V. Hartstra, Willem M. de Vos, Mireille J. Serlie, Max Nieuwdorp, Pim W. Gilijamse, Marleen Kemper, Koen Wortelboer

Publikováno v: NPJ biofilms and microbiomes, 6(1):16. Nature Publishing Group
NPJ Biofilms and Microbiomes
npj Biofilms and Microbiomes, Vol 6, Iss 1, Pp 1-10 (2020)
npj Biofilms and Microbiomes, 6(1)
npj Biofilms and Microbiomes 6 (2020) 1

Dysbiosis of the intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We performed a phase I/II dose-finding and safety study on the effect of oral intake of the anaerobic butyrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e2669db569774b8c8f839cc61e6857
https://pure.amc.nl/en/publications/treatment-with-anaerobutyricum-soehngenii-a-pilot-study-of-safety-and-doseresponse-effects-on-glucose-metabolism-in-human-subjects-with-metabolic-syndrome(c0f157f5-fa71-458b-baa7-ba59427bfab7).html

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The relation between postprandial glucagon-like peptide-1 release and insulin sensitivity before and after bariatric surgery in humans with class II/III obesity

Autor: Pim W. Gilijamse, Bart A. van Wagensveld, Johannes A. Romijn, Mariëtte T. Ackermans, Mireille J. Serlie, Ahmet Demirkiran, Max Nieuwdorp, Kasper W. ter Horst

Publikováno v: Surgery for obesity and related diseases, 17(8), 1440-1448. Elsevier Inc.

Background Glucagon-like peptide-1 (GLP-1) receptor agonist treatment is beneficial for human glucose metabolism, and GLP-1 secretion is greatly enhanced following Roux-en-Y gastric bypass (RYGB). Objectives The objectives of this study were to eluci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313d65c900689d1d413a8ad920114b7f
https://pubmed.ncbi.nlm.nih.gov/34210589

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The pathophysiology of human obstructive cholestasis is mimicked in cholestatic Gold Syrian hamsters

Autor: Michal Heger, Rowan F. van Golen, Lianne R. de Haan, Mark J de Keijzer, Dirk R. de Waart, André B.P. van Kuilenburg, Alexandros Pechlivanis, Pim W. Gilijamse, Jeremy K. Nicholson, R. Coelen, Jeroen Roelofsen, Pim B. Olthof, M. Maas, Matthew R. Lewis, Ruud Weijer, Joanne Verheij

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1864(3), 942-951. Elsevier

Obstructive cholestasis causes liver injury via accumulation of toxic bile acids (BAs). Therapeutic options for cholestatic liver disease are limited, partially because the available murine disease models lack translational value. Profiling of time-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc13e2bfbca91f60bc812116bfb4f74
https://doi.org/10.1016/j.bbadis.2017.11.022

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Methods for quantifying adipose tissue insulin resistance in overweight/obese humans

Autor: Pim W. Gilijamse, Mariëtte T. Ackermans, F M van der Valk, Annick V. Hartstra, Johannes A. Romijn, K.A. van Galen, Mireille J. Serlie, K.W. ter Horst, P F de Groot, Max Nieuwdorp

Publikováno v: International Journal of Obesity, 41(8), 1288-1294. Nature Publishing Group
International journal of obesity (2005), 41(8), 1288-1294. Nature Publishing Group
Ter Horst, K W, Van Galen, K A, Gilijamse, P W, Hartstra, A V, De Groot, P F, Van Der Valk, F M, Ackermans, M T, Nieuwdorp, M, Romijn, J A & Serlie, M J 2017, ' Methods for quantifying adipose tissue insulin resistance in overweight/obese humans ', International Journal of Obesity, vol. 41, no. 8, pp. 1288-1294 . https://doi.org/10.1038/ijo.2017.110

BACKGROUND/OBJECTIVES: Insulin resistance of adipose tissue is an important feature of obesity-related metabolic disease. However, assessment of lipolysis in humans requires labor-intensive and expensive methods, and there is limited validation of si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695852ef18fda8f8e82d29cf85c9654e
http://www.scopus.com/inward/record.url?scp=85026901010&partnerID=8YFLogxK

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The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women

Autor: Richard Trinko, Johannes A. Romijn, Pim W. Gilijamse, Mariëtte T. Ackermans, S.E. la Fleur, K.W. ter Horst, Ruth I. Versteeg, Annemieke C. Heijboer, Ralph J. DiLeone, Mireille J. Serlie

Publikováno v: ter Horst, K W, Versteeg, R I, Gilijamse, P W, Ackermans, M T, Heijboer, A C, Romijn, J A, la Fleur, S E, Trinko, R, DiLeone, R J & Serlie, M J 2016, ' The vitamin D metabolites 25(OH)D and 1,25(OH) 2 D are not related to either glucose metabolism or insulin action in obese women ', Diabetes and Metabolism, vol. 42, no. 6, pp. 416-423 . https://doi.org/10.1016/j.diabet.2016.04.011
Diabetes and Metabolism, 42(6), 416-423. Elsevier Masson
Diabetes & metabolism, 42(6), 416-423. Elsevier Masson

Aim: Vitamin D deficiency has been proposed to be involved in obesity-induced metabolic disease. However, data on the relationship between 25-hydroxycholecalciferol (25(OH)D) and insulin resistance have been inconsistent, and few studies have investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41cc1d2ea94b3ae8379833f0be3c783
https://doi.org/10.1016/j.diabet.2016.04.011

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