Transplantation and Noninvasive Longitudinal Imaging of Parathyroid Cells: A Proof-of-Concept Study

Autor: Robert Bränström, Pim P. van Krieken, Robin Fröbom, C. Christofer Juhlin, Ivan Shabo, Barbara Leibiger, Ingo B. Leibiger, Per-Olof Berggren, Craig A. Aspinwall

Publikováno v: Cell Transplantation, Vol 33 (2024)

The parathyroid cell is a vital regulator of extracellular calcium levels, operating through the secretion of parathyroid hormone (PTH). Despite its importance, the regulation of PTH secretion remains complex and not fully understood, representing a

Externí odkaz: https://doaj.org/article/e08b538003074edf8f6c2ca62bcfbaf1

Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes

Autor: Max Hahn, Christoffer Nord, Pim P. van Krieken, Per-Olof Berggren, Erwin Ilegems, Abbas Cheddad, Ulf Ahlgren

Publikováno v: Scientific Data, Vol 9, Iss 1, Pp 1-8 (2022)

Measurement(s) Fluorescent antibody staining of Insulin and GLUT2 in whole mouse pancreata Technology Type(s) Optical Projection Tomography • Light Sheet Fluorescence Microscopy (Ultramicroscope) Factor Type(s) mouse genotype • Streptozotocin dos

Externí odkaz: https://doaj.org/article/4c853eb7ddd64f41a76ea2fb3e5e8ef5

Translational assessment of a genetic engineering methodology to improve islet function for transplantationResearch in context

Autor: Pim P. van Krieken, Anna Voznesenskaya, Andrea Dicker, Yan Xiong, Jae Hong Park, Jeong Ik Lee, Erwin Ilegems, Per-Olof Berggren

Publikováno v: EBioMedicine, Vol 45, Iss , Pp 529-541 (2019)

Background: The functional quality of insulin-secreting islet beta cells is a major factor determining the outcome of clinical transplantations for diabetes. It is therefore of importance to develop methodological strategies aiming at optimizing isle

Externí odkaz: https://doaj.org/article/3508f94488a544bcbcf19e8b71742705

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

Autor: Daniel Konrad, Matthias Blüher, Stephan Wueest, Timothy S. Odermatt, Pim P. van Krieken, Marcela Borsigova

Publikováno v: Mol. Metab. 54:101341 (2021)
Molecular Metabolism
Molecular Metabolism, Vol 54, Iss, Pp 101341-(2021)

Objective Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b294f6fd8a0dd2dac9a5fb90713576d
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63028

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice

Autor: Cindy J.M. Loomans, Erik W.L. Jansen, Gitanjali Dharmadhikari, Femke Ringnalda, Léon van Gurp, Eelco J.P. de Koning, Evelyne Beerling, Jacco van Rheenen, Pim P. van Krieken

Publikováno v: Diabetologia
Diabetologia, 59, 11, pp. 2387-92
Diabetologia. Springer Verlag GmbH
Diabetologia, 59, 2387-92
Diabetologia, 59(11), 2387-2392
Diabetologia, 59 (11)
Diabetologia, 59(11), 2387. Springer Verlag

Aims/hypothesis Dynamic processes in pancreatic tissue are difficult to study. We aimed to develop an intravital imaging method to longitudinally examine engraftment, vascularisation, expansion and differentiation in mature islets or embryonic pancre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89a9287a1f69917ce9b1dd9f3dfafcd
https://doi.org/10.1007/s00125-016-4049-6