A Multimodal Biomarker Predicts Dissemination of Bronchial Carcinoid

Autor: Ellen M. B. P. Reuling, Dwayne D. Naves, Pim C. Kortman, Mark A. M. Broeckaert, Peter W. Plaisier, Chris Dickhoff, Johannes M. A. Daniels, Teodora Radonic

Publikováno v: Cancers; Volume 14; Issue 13; Pages: 3234
Reuling, E M B P, Naves, D D, Kortman, P C, Broeckaert, M A M, Plaisier, P W, Dickhoff, C, Daniels, J M A & Radonic, T 2022, ' A Multimodal Biomarker Predicts Dissemination of Bronchial Carcinoid ', Cancers, vol. 14, no. 13, 3234 . https://doi.org/10.3390/cancers14133234

Background: Curatively treated bronchial carcinoid tumors have a relatively low metastatic potential. Gradation into typical (TC) and atypical carcinoid (AC) is limited in terms of prognostic value, resulting in yearly follow-up of all patients. We e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1caa370fc984b2fba9ba963808f48b73

Diagnosis of atypical carcinoid can be made on biopsies > 4 mm2 and is accurate

Autor: Ellen M. B. P. Reuling, Dwayne D. Naves, Johannes M. A. Daniels, Chris Dickhoff, Pim C. Kortman, Mark A. M. B. Broeckaert, Peter W. Plaisier, Erik Thunnissen, Teodora Radonic

Publikováno v: Virchows Archiv, 480(3), 587-593. Springer Verlag
Reuling, E M B P, Naves, D D, Daniels, J M A, Dickhoff, C, Kortman, P C, Broeckaert, M A M B, Plaisier, P W, Thunnissen, E & Radonic, T 2022, ' Diagnosis of atypical carcinoid can be made on biopsies > 4 mm2 and is accurate ', Virchows Archiv, vol. 480, no. 3, pp. 587-593 . https://doi.org/10.1007/s00428-022-03279-7, https://doi.org/10.1007/s00428-022-03279-7

In the 2021 WHO thoracic tumors, gradation of lung carcinoids in biopsies is discouraged. We hypothesized that atypical carcinoid (AC) could be reliably diagnosed in larger preoperative biopsies. Biopsy-resection paired specimens of carcinoid patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac1faf628485e6d88b91fcc169b8109
https://research.vumc.nl/en/publications/60e491c2-ae53-4a75-9bdd-50dc82c3db7f

Diagnostic Accuracy in Bronchial Carcinoid tumors is Dependent of Biopsy Size

Autor: Mark A. M. B. Broeckaert, Teodora Radonic, Chris Dickhoff, Johannes M.A. Daniels, Dwayne D. Naves, Pim C. Kortman, Erik Thunnissen, Ellen M. B. P. Reuling, Peter W. Plaisier

ObjectiveRecently, 60% discordancy was reported for distinction between typical carcinoid and atypical carcinoid in preoperative biopsy compared to the resection specimen. This study investigated the impact of biopsy surface size, obtained with flexi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b17637baa1222c0d456517d3560c746
https://doi.org/10.1101/2021.05.20.21257521

Abrogation of BRAF(V600E)-induced senescence by PI3K pathway activation contributes to melanomagenesis

Autor: Hugo M. Horlings, Martin McMahon, Katrin Meissl, Daniel S. Peeper, Marjon A. Smit, David Dankort, Chrysiis Michaloglou, Patricia A. Possik, Wolter J. Mooi, Abderrahim Ajouaou, Liesbeth C.W. Vredeveld, Pim C. Kortman

Publikováno v: Vredeveld, L C W, Possik, P A, Smit, M A, Meissl, K, Michaloglou, C, Horlings, H M, Ajouaou, A, Kortman, P C, Dankort, D, McMahon, M, Mooi, W J & Peeper, D S 2012, ' Abrogation of BRAF(V600E)-induced senescence by PI3K pathway activation contributes to melanomagenesis ', Genes and Development, vol. 26, no. 10, pp. 1055-1069 . https://doi.org/10.1101/gad.187252.112
Genes and Development, 26(10), 1055-1069. Cold Spring Harbor Laboratory Press

Human melanocytic nevi (moles) are benign lesions harboring activated oncogenes, including BRAF. Although this oncogene initially acts mitogenically, eventually, oncogene-induced senescence (OIS) ensues. Nevi can infrequently progress to melanomas, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2ba8a75a27e8807f5d1a8aebdfea0c
https://doi.org/10.1101/gad.187252.112